Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Michele M. Klingbeil"'
Publikováno v:
Biochemistry. 61:2751-2765
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec18be7f8a8cb0a00ae04d00ddce577
https://doi.org/10.1021/acs.biochem.2c00392
https://doi.org/10.1021/acs.biochem.2c00392
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT Mitochondrial chaperones have multiple functions that are essential for proper functioning of mitochondria. In the human-pathogenic protist Trypanosoma brucei, we demonstrate a novel function of the highly conserved machinery composed of mit
Externí odkaz:
https://doaj.org/article/a9b46241a9a84103bd0f4e9e924e1b64
Publikováno v:
Molecular Biology of the Cell
Trypanosoma brucei has a unique catenated mitochondrial DNA (mtDNA) network called kinetoplast DNA (kDNA). Replication of kDNA occurs once per cell cycle in near synchrony with nuclear S phase and requires the coordination of many proteins. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e12675fb3165e03f50b6471cfae2cc
https://doi.org/10.1091/mbc.e18-02-0127
https://doi.org/10.1091/mbc.e18-02-0127
Autor:
Jonathan C. Miller, Jeniffer Concepción-Acevedo, Michael J. Boucher, Stephanie B. Delzell, Michele M. Klingbeil
Publikováno v:
J Cell Sci
Mitochondrial DNA of Trypanosoma brucei and related parasites is a catenated network containing thousands of minicircles and tens of maxicircles, called kinetoplast DNA (kDNA). Replication of a single nucleoid requires at least three DNA polymerase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a12e3377015c3f5ac6759cece3d90a
https://pubmed.ncbi.nlm.nih.gov/32079654
https://pubmed.ncbi.nlm.nih.gov/32079654
Autor:
Maria C. Rocha-Granados, Yahaira Bermudez, Garvin Dodard, Anthula V. Vandoros, Michele M. Klingbeil, Arthur Günzl
DNA replication, transcription and chromatin remodeling are coordinated to ensure accurate duplication of genetic and epigenetic information. In regard to DNA replication, trypanosomatid parasites such asTrypanosoma bruceidisplay unusual properties i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26e74926bdf51a89f4cd99ee709f70c
Publikováno v:
Computational and Mathematical Biophysics, Vol 2, Iss 1, Pp 98-106 (2014)
Trypanosomatida parasites, such as Trypanosoma and Leishmania, are the cause of deadly diseases in many third world countries. The three dimensional structure of their mitochondrial DNA, known as kinetoplast DNA (kDNA), is unique since it is organize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6573b4c4171fd492034f3de47ed2d8f2
https://doi.org/10.2478/mlbmb-2014-0007
https://doi.org/10.2478/mlbmb-2014-0007
Publikováno v:
Journal of Physics A: Mathematical and Theoretical. 52:034001
The mitochondrial DNA of trypanosomes, called kinetoplast DNA (kDNA) contains thousands of minicircles that are topologically linked into a single structure that resembles a medieval chainmail. This biological chainmail is characterized by two parame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36293128c00ef1166366b4032c395e85
https://doi.org/10.1088/1751-8121/aaf15f
https://doi.org/10.1088/1751-8121/aaf15f
Autor:
George A. M. Cross, Michele M. Klingbeil, Jeniffer Concepción-Acevedo, Bibo Li, Hee-Sook Kim, Imaan Benmerzouga, Anthula V. Vandoros
Publikováno v:
Molecular Microbiology. 87:196-210
Summary Binding of the Origin Recognition Complex (ORC) to replication origins is essential for initiation of DNA replication, but ORC has non-essential functions outside of DNA replication, including in heterochromatic gene silencing and telomere ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4932c34e2b8fd55a0af2c58560cdec25
https://doi.org/10.1111/mmi.12093
https://doi.org/10.1111/mmi.12093
Publikováno v:
Scientific Reports
Leishmania and Trypanosoma are unicellular parasites that possess markedly original biological features as compared to other eukaryotes. The Leishmania genome displays a constitutive ‘mosaic aneuploidy’, whereas in Trypanosoma brucei, the megabas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5f15129114409014548c3bac34af87
https://pubmed.ncbi.nlm.nih.gov/26976742
https://pubmed.ncbi.nlm.nih.gov/26976742
Publikováno v:
Eukaryotic Cell. 11:844-855
Trypanosomes contain a unique form of mitochondrial DNA called kinetoplast DNA (kDNA) that is a catenated network composed of minicircles and maxicircles. Several proteins are essential for network replication, and most of these localize to the antip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25913aa4f62c2f32bb64ec8800c7dd1
https://doi.org/10.1128/ec.05291-11
https://doi.org/10.1128/ec.05291-11