Zobrazeno 1 - 10 of 66 pro vyhledávání: '"Michele M Castro"'
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Akademický článek
Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk.
Autor: Fanny Huyard, Catherine Yzydorczyk, Michele M Castro, Anik Cloutier, Mariane Bertagnolli, Hervé Sartelet, Nathalie Germain, Blandine Comte, Richard Schulz, Denis DeBlois, Anne Monique Nuyt
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e92287 (2014)
Neonatal high-oxygen exposure leads to elevated blood pressure, microvascular rarefaction, vascular dysfunction and arterial (aorta) rigidity in adult rats. Whether structural changes are present in the matrix of aorta wall is unknown. Considering th
Externí odkaz: https://doaj.org/article/5673bd8449ff437582d837c3e1bf52f9
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4
Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity
Autor: Natália A. Gonzaga, Carla Brigagão Pacheco da Silva, Gabriel T. do Vale, Carlos R. Tirapelli, Michele M. Castro, Juliana M. Parente, Katiúscia M Araújo, Arthur H. Sousa
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Changes in redox state are described in the early stages of ethanol-induced cardiac toxicity. Here, we evaluated whether nebivolol would abrogate ethanol-induced redox imbalance in the heart. Male Wistar rats were treated with a solution of ethanol (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b5e61ccd063b375b85300ab2a9559f
https://doi.org/10.1007/s12012-020-09614-1
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5
Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects
Autor: Elen Rizzi, Raquel F. Gerlach, Jefferson H. Amaral, Danielle A. Guimaraes, Sandra O. Conde-Tella, Lucas C. Pinheiro, Michele M. Castro, Jose E. Tanus-Santos
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Hypertension is associated with cardiovascular remodeling. Given that impaired redox state activates matrix metalloproteinase (MMP)− 2 and promotes vascular remodeling, we hypothesized that nitrite treatment at a non-antihypertensive dose exerts an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ab4f79df0c175304300f3ae89035d4
https://doi.org/10.1016/j.freeradbiomed.2018.11.002
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6
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney
Autor: Bruno De Martinis, Michele M. Castro, Carla Brigagão Pacheco da Silva, Carla Speroni Ceron, Atlante S. Mendes, Carlos R. Tirapelli
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Overexpression of the inducible isoform of the enzyme nitric oxide synthase (iNOS) has been associated to pathological processes in the kidney. Ethanol consumption induces the renal expression of iNOS; however, the contribution of this enzyme to the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f4bdedcae1f45ba323798473c1b570
https://pubmed.ncbi.nlm.nih.gov/33887163
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7
Omeprazole induces vascular remodeling by mechanisms involving xanthine oxidoreductase and matrix metalloproteinase activation
Autor: Jessica M. Sanches-Lopes, Gustavo H. Oliveira-Paula, Renato C. Nogueira, Jose E. Tanus-Santos, Sandra O. Conde, Lucas C. Pinheiro, Juliana M. Parente, Michele M. Castro
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Proton pump inhibitors (PPI) are commonly used drugs that may increase the cardiovascular risk by mechanisms not entirely known. We examined whether the PPI omeprazole promotes vascular oxidative stress mediated by xanthine oxidoreductase (XOR) leadi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eadcff74ca318644eebebf44959f74c
https://pubmed.ncbi.nlm.nih.gov/34058185
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8
Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy
Autor: Danielle A. Guimaraes, Raquel F. Gerlach, Madla A. Passos, Elen Rizzi, Lucas C. Pinheiro, Jose E. Tanus-Santos, Michele M. Castro, Jefferson H. Amaral
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cardiac hypertrophy is a common consequence of chronic hypertension and leads to heart failure and premature death. The anion nitrite is now considered as a bioactive molecule able to exert beneficial cardiovascular effects. Previous results showed t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a479e0970bc77233d7f2f84f52df9a1f
https://doi.org/10.1016/j.freeradbiomed.2018.03.006
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9
Long-Term Excessive Selenium Supplementation Induces Hypertension in Rats
Autor: Solange Cristina Garcia, Fernando Barbosa Júnior, Maria Fernanda Hornos Carneiro, Denise Grotto, Michele M. Castro
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Selenium (Se) is an essential trace element involved in several biological pathways, naturally found in rocks, soils, and food. Even though the daily requirement of Se is achieved through a balanced diet, the use of Se supplements has been frequent.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf89ca2e5a660a296852fa332a5798ca
https://doi.org/10.1007/s12011-017-1076-1
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10
Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling
Autor: Michele M. Castro, Camila A. Pereira, Juliana M. Parente, Gustavo H. Oliveira-Paula, Rita C. Tostes, Jose E. Tanus-Santos
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Matrix metalloproteinase (MMP)-2 participates in hypertension-induced maladaptive vascular remodelling by degrading extra- and intracellular proteins. The consequent extracellular matrix rearrangement and phenotype switch of vascular smooth muscle ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a2037513cc90b7af24536d632c7c2d
https://doi.org/10.1111/bcpt.12787
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