Výsledky vyhledávání - "Michele I, Vitolo"

Akademický článek

Microtubule disruption reduces metastasis more effectively than primary tumor growth

Autor: Keyata N. Thompson, Julia A. Ju, Eleanor C. Ory, Stephen J. P. Pratt, Rachel M. Lee, Trevor J. Mathias, Katarina T. Chang, Cornell J. Lee, Olga G. Goloubeva, Patrick C. Bailey, Kristi R. Chakrabarti, Christopher M. Jewell, Michele I. Vitolo, Stuart S. Martin

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-21 (2022)

Abstract Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic phenotypes of microtentacles, reattachment and tumor cell clustering more than tumor

Externí odkaz: https://doaj.org/article/16b3a6a66cbd4783a10d41a52c7ae93f

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Akademický článek

Label-free cell tracking enables collective motion phenotyping in epithelial monolayers

Autor: Shuyao Gu, Rachel M. Lee, Zackery Benson, Chenyi Ling, Michele I. Vitolo, Stuart S. Martin, Joe Chalfoun, Wolfgang Losert

Publikováno v: iScience, Vol 25, Iss 7, Pp 104678- (2022)

Summary: Collective cell migration is an umbrella term for a rich variety of cell behaviors, whose distinct character is important for biological function, notably for cancer metastasis. One essential feature of collective behavior is the motion of c

Externí odkaz: https://doaj.org/article/462a0c8916aa4a2695b173d8bca64579

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Akademický článek

Distinct roles of tumor associated mutations in collective cell migration

Autor: Rachel M. Lee, Michele I. Vitolo, Wolfgang Losert, Stuart S. Martin

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Recent evidence suggests that groups of cells are more likely to form clinically dangerous metastatic tumors, emphasizing the importance of understanding mechanisms underlying collective behavior. The emergent collective behavior of migratin

Externí odkaz: https://doaj.org/article/52e98a1d193241efaa5f9c94a3440def

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Akademický článek

Hydrogen Peroxide Induces α-Tubulin Detyrosination and Acetylation and Impacts Breast Cancer Metastatic Phenotypes

Autor: Megan B. Stemberger, Julia A. Ju, Keyata N. Thompson, Trevor J. Mathias, Alexandra E. Jerrett, Katarina T. Chang, Eleanor C. Ory, David A. Annis, Makenzy L. Mull, Darin E. Gilchrist, Michele I. Vitolo, Stuart S. Martin

Publikováno v: Cells, Vol 12, Iss 9, p 1266 (2023)

Levels of hydrogen peroxide are highly elevated in the breast tumor microenvironment compared to normal tissue. Production of hydrogen peroxide is implicated in the mechanism of action of many anticancer therapies. Several lines of evidence suggest h

Externí odkaz: https://doaj.org/article/fff120d70ebf46c392e1750ff30f723f

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Akademický článek

Lipid tethering of breast tumor cells reduces cell aggregation during mammosphere formation

Autor: Lekhana Bhandary, Patrick C. Bailey, Katarina T. Chang, Karen F. Underwood, Cornell J. Lee, Rebecca A. Whipple, Christopher M. Jewell, Eleanor Ory, Keyata N. Thompson, Julia A. Ju, Trevor M. Mathias, Stephen J. P. Pratt, Michele I. Vitolo, Stuart S. Martin

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Mammosphere assays are widely used in vitro to identify prospective cancer-initiating stem cells that can propagate clonally to form spheres in free-floating conditions. However, the traditional mammosphere assay inevitably introduces cell a

Externí odkaz: https://doaj.org/article/7fa9e6ad3962419dbe47d6107797d52b

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Akademický článek

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

Autor: Yohan Suryo Rahmanto, Wenjing Shen, Xu Shi, Xi Chen, Yu Yu, Zheng-Cheng Yu, Tsutomu Miyamoto, Meng-Horng Lee, Vivek Singh, Ryoichi Asaka, Geoffrey Shimberg, Michele I. Vitolo, Stuart S. Martin, Denis Wirtz, Ronny Drapkin, Jianhua Xuan, Tian-Li Wang, Ie-Ming Shih

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

ARID1A, which is often mutated in human endometrial cancer, is a component of the SWI/SNF chromatin remodelling complex. Here, the authors show that Arid1a mutations in the mouse endometrium and primary human endometrial epithelial cells cause widesp

Externí odkaz: https://doaj.org/article/75bea59380ee4facabb9a13db669ea7a

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Akademický článek

Single-Cell Tracking of Breast Cancer Cells Enables Prediction of Sphere Formation from Early Cell Divisions

Autor: Patrick C. Bailey, Rachel M. Lee, Michele I. Vitolo, Stephen J.P. Pratt, Eleanor Ory, Kristi Chakrabarti, Cornell J. Lee, Keyata N. Thompson, Stuart S. Martin

Publikováno v: iScience, Vol 8, Iss , Pp 29-39 (2018)

Summary: The mammosphere assay has become widely employed to quantify stem-like cells in a population. However, the problem is there is no standard protocol employed by the field. Cell seeding densities of 1,000 to 100,000 cells/mL have been reported

Externí odkaz: https://doaj.org/article/5ecf840c180a4be4af26ec43d803e3e3

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