Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michele Graciotti"'
Autor:
Hajer Fritah, Michele Graciotti, Cheryl Lai-Lai Chiang, Anne-Laure Huguenin- Bergenat, Rémy Petremand, Ritaparna Ahmed, Philippe Guillaume, Julien Schmidt, Brian J. Stevenson, David Gfeller, Alexandre Harari, Lana E. Kandalaft
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106288- (2023)
Summary: Antigen selection and prioritization represent crucial determinants of vaccines’ efficacy. Here, we compare two personalized dendritic cell-based vaccination strategies using whole-tumor lysate or neoantigens. Data in mouse and in cancer p
Externí odkaz:
https://doaj.org/article/9001342654b947c8becf2723dc803e5f
Autor:
Rita Ahmed, Isaac Crespo, Sandra Tuyaerts, Amel Bekkar, Michele Graciotti, Ioannis Xenarios, Lana E. Kandalaft
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2217-2227 (2020)
Dendritic cell (DC)-based vaccines have been largely used in the adjuvant setting for the treatment of cancer, however, despite their proven safety, clinical outcomes still remain modest. In order to improve their efficacy, DC-based vaccines are ofte
Externí odkaz:
https://doaj.org/article/c523921c44ac44bebbc14b920683978a
Publikováno v:
BioImpacts, Vol 8, Iss 3, Pp 211-221 (2018)
Introduction: Ovarian cancer is one of the most lethal gynecologic cancers. Relapses after remission are common, hence novel strategies are urgently needed. Our group has previously developed a vaccination approach based on dendritic cells pulsed wit
Externí odkaz:
https://doaj.org/article/12713feafc624513a9c5a05246d99a0c
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-16 (2017)
Abstract Background Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the
Externí odkaz:
https://doaj.org/article/b8a78771410746d2b2c11f5179f4c7b5
Autor:
Michele Graciotti, Fabio Marino, HuiSong Pak, Petra Baumgaertner, Anne-Christine Thierry, Johanna Chiffelle, Marta A. S. Perez, Vincent Zoete, Alexandre Harari, Michal Bassani-Sternberg, Lana E. Kandalaft
Publikováno v:
Vaccines, Vol 8, Iss 2, p 271 (2020)
Hypochlorous acid (HOCl)-treated whole tumor cell lysates (Ox-L) have been shown to be more immunogenic when used as an antigen source for therapeutic dendritic cell (DC)-based vaccines, improving downstream immune responses both in vitro and in vivo
Externí odkaz:
https://doaj.org/article/4cb72e9288fc4a06a2a4661378814de5
Publikováno v:
BioImpacts, Vol 9, Iss 1, Pp 65-65 (2019)
This corrects the article "A cancer vaccine with dendritic cells differentiated with GM-CSF and IFNα and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model" published on 2018: Volume 08,
Externí odkaz:
https://doaj.org/article/0188d53d9f81468182a909a34cb946ff
Publikováno v:
Cancers, Vol 11, Iss 1, p 40 (2019)
In the last 20 years, dendritic cells (DCs) have been largely used as a platform for therapeutic vaccination in cancer patients. However, despite its proven safety and ability to induce cancer specific immune responses, the clinical benefits of DC-ba
Externí odkaz:
https://doaj.org/article/ffe8b8bff8234ef1aaf5ea1a31c782d5
Publikováno v:
Vaccines, Vol 6, Iss 4, p 79 (2018)
Although different types of therapeutic vaccines against established cancerous lesions in various indications have been developed since the 1990s, their clinical benefit is still very limited. This observed lack of effectiveness in cancer eradication
Externí odkaz:
https://doaj.org/article/028c8a16178845168da5ccefc0000caa
Autor:
Michele Graciotti, Mahmood Alam, Lev Solyakov, Ralf Schmid, Glenn Burley, Andrew R Bottrill, Christian Doerig, Paul Cullis, Andrew B Tobin
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e85391 (2014)
Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis. Here we report a detailed ana
Externí odkaz:
https://doaj.org/article/fd256cc187a84d6d8bb110eff21ef99b
Autor:
Cristiana Berti, Alice Boarino, Lisa P. E. Bader, Harm-Anton Klok, Lana E. Kandalaft, Michele Graciotti
Publikováno v:
ACS Applied Bio Materials. 4:8291-8300
Peptides and proteins represent an emerging class of powerful therapeutics. Peptide and protein nanogels are attractive carriers for the transport and delivery of biologically active peptides and proteins because they allow essentially quantitative e