Výsledky vyhledávání - "Michele Ghezzo"

Structural characterization of a cytosine-rich potential quadruplex forming sequence in the EGFR promoter

Publikováno v: Journal of Thermal Analysis and Calorimetry. 148:5375-5385

I-motifs are tetra-helixes that may form in cytosine-rich strands. They are based on cytosine–cytosine+ base pairs that require the N3 hemi-protonation of the nucleobases, and therefore, the stability of these non-canonical DNA arrangements depends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2745f8c8509cadbbfe41f80d98f15d4a
https://doi.org/10.1007/s10973-023-12060-0

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pH-driven conformational switch between non-canonical DNA structures in a C-rich domain of EGFR promoter

Autor: Riccardo Rigo, Claudia Sissi, Camilla Cristofari, Maria Laura Greco, Michele Ghezzo

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

EGFR is an oncogene that encodes for a trans-membrane tyrosine kinase receptor. Its mis-regulation is associated to several human cancers that, consistently, can be treated by selective tyrosine kinase inhibitors. The proximal promoter of EGFR contai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26baa91b89eadc5f9c4856077730f33d
https://doi.org/10.1038/s41598-018-37968-8

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