Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Michele F Rega"'
Autor:
Jun eWei, John L Stebbins, Shinichi eKitada, Rupesh eDash, Dayong eZhai, William J Placzek, Bainan eWu, Michele F Rega, Ziming eZhang, Elisa eBarile, Li eYang, Russell eDahl, Paul B. Fisher, John C Reed, Maurizio ePellecchia
Publikováno v:
Frontiers in Oncology, Vol 1 (2011)
Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (+/-) BI97D6. We report here t
Externí odkaz:
https://doaj.org/article/9da35fc70df844858b05d2972780c82d
Autor:
Maurizio Pellecchia, John C. Reed, Said Sebti, Nicholas Lawrence, Tyler A. Reed, Si Wang, Bainan Wu, Ziming Zhang, Russell Dahl, Li Yang, Jiazhi Sun, Dayong Zhai, John L. Stebbins, Jason Cellitti, Hongbin Yuan, Aras Emdadi, Michele F. Rega, Shinichi Kitada, Jun Wei
Guided by a combination of nuclear magnetic resonance binding assays and computational docking studies, we synthesized a library of 5,5′ substituted Apogossypol derivatives as potent Bcl-XL antagonists. Each compound was subsequently tested for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604ac48de033a8db9e0fdc42766287b4
https://doi.org/10.1158/1535-7163.c.6531807
https://doi.org/10.1158/1535-7163.c.6531807
Autor:
Maurizio Pellecchia, John C. Reed, Said Sebti, Nicholas Lawrence, Tyler A. Reed, Si Wang, Bainan Wu, Ziming Zhang, Russell Dahl, Li Yang, Jiazhi Sun, Dayong Zhai, John L. Stebbins, Jason Cellitti, Hongbin Yuan, Aras Emdadi, Michele F. Rega, Shinichi Kitada, Jun Wei
Supplementary Data from Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95bebc910184fa8416d57f584ffdc4e
https://doi.org/10.1158/1535-7163.22485165
https://doi.org/10.1158/1535-7163.22485165
Autor:
Serena Leone, Federica Donnarumma, Andrea Pica, Alessandro Emendato, Rocco Di Girolamo, Michele F. Rega, Antonello Merlino, Delia Picone
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:808-815
Background MNEI and its variant Y65R-MNEI are sweet proteins with potential applications as sweeteners in food industry. Also, they are often used as model systems for folding and aggregation studies. Methods X-ray crystallography was used to structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7536a3fef80fe1c20d6ab7bf45169f71
https://doi.org/10.1016/j.bbagen.2017.12.012
https://doi.org/10.1016/j.bbagen.2017.12.012
Autor:
Renato Gesuele, Andrea Carpentieri, Michele F. Rega, Delia Picone, Giusy Lofrano, Marco Guida, Antonietta Siciliano
Publikováno v:
Environmental science and pollution research international. 24(10)
Low-calorie sweeteners are widespread. They are routinely introduced into commonly consumed food such as diet sodas, cereals, and sugar-free desserts. Recent data revealed the presence in considerable quantities of some of these artificial sweeteners
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fcf342fcad852dbf0f7a388188aa79
https://pubmed.ncbi.nlm.nih.gov/28251536
https://pubmed.ncbi.nlm.nih.gov/28251536
Autor:
Nicoletta A, Miele, Rossella, Di Monaco, Francesca, Dell'Amura, Michele F, Rega, Delia, Picone, Silvana, Cavella
Publikováno v:
Journal of texture studies. 48(2)
Natural sweet proteins may be used as sugar replacer in simple liquid food systems but their applicability in more complex matrices has not been investigated yet. Gelling agent nature and texture characteristics as well as type and distribution of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b53616f72efd44cdef972ac632880472
https://pubmed.ncbi.nlm.nih.gov/28370108
https://pubmed.ncbi.nlm.nih.gov/28370108
Autor:
Russell Dahl, Bainan Wu, Maurizio Pellecchia, Hongbin Yuan, Jun Wei, Michele F. Rega, Ziming Zhang
Publikováno v:
Chemical Biology & Drug Design. 73:369-379
Pin1 plays a key role in various biological cellular processes via the recognition of phosphorylated Ser/Thr-Proline motifs. Moreover, high expression levels of Pin1 are correlated to tumorgenesis in some cancer types. Here, we identify a novel serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8687b4b1e3796beeaae2b040235278
https://doi.org/10.1111/j.1747-0285.2009.00795.x
https://doi.org/10.1111/j.1747-0285.2009.00795.x
Autor:
Aras Emdadi, Jason Cellitti, Megan Riel-Mehan, Maurizio Pellecchia, Surya K. De, Michele F. Rega, John L. Stebbins, Li-Hsing Chen, Jesus Vazquez
Publikováno v:
Journal of Medicinal Chemistry. 51:3460-3465
We report on the synthesis and evaluation of an indazole-spin-labeled compound that was designed as an effective chemical probe for second site screening against the protein kinase JNK using NMR-based techniques. We demonstrate the utility of the der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116307b3c7e4af2c57819913200f9eca
https://doi.org/10.1021/jm800068w
https://doi.org/10.1021/jm800068w
Autor:
Delia Picone, Rossella Di Monaco, Federica Donnarumma, Michele F. Rega, Serena Leone, Silvana Cavella, Roberta Spadaccini
Publikováno v:
Food chemistry. 173
Sweet proteins represent a class of natural molecules, which are extremely interesting regarding their potential use as safe low-calories sweeteners for individuals who need to control sugar intake, such as obese or diabetic subjects. Punctual mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f847d1304722bb197712d25911aa8f
https://pubmed.ncbi.nlm.nih.gov/25466141
https://pubmed.ncbi.nlm.nih.gov/25466141
Autor:
John C. Reed, Dayong Zhai, Rupesh Dash, Shinichi Kitada, William J. Placzek, Li Yang, John L. Stebbins, Bainan Wu, Paul B. Fisher, Michele F. Rega, Jun Wei, Maurizio Pellecchia, Russell Dahl, Elisa Barile, Ziming Zhang
Publikováno v:
Frontiers in Oncology, Vol 1 (2011)
Frontiers in Oncology
Frontiers in Oncology
Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (+/-) BI97D6. We report here t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93e38bf3ec01d9c57497fbf595868e0
http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00028/full
http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00028/full