A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research

Autor: Xiaoqian Jiang, Lavanya Nookala, Grace M. Kuo, Frederic S. Resnic, Hyeoneui Kim, Robert El-Kareh, Laura Pearlman, Michael E. Matheny, Lucila Ohno-Machado, Katherine K. Kim, Michele E. Day, Daniella Meeker, Michel D'Arcy, Claudiu Farcas, Aziz A. Boxwala, Carl Kesselman

Publikováno v: Journal of the American Medical Informatics Association : JAMIA, vol 22, iss 6
Journal of the American Medical Informatics Association : JAMIA
Meeker, D; Jiang, X; Matheny, ME; Farcas, C; D'Arcy, M; Pearlman, L; et al.(2015). A system to build distributed multivariate models and manage disparate data sharing policies: Implementation in the scalable national network for effectiveness research. Journal of the American Medical Informatics Association, 22(6), 1187-1195. doi: 10.1093/jamia/ocv017. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/82p1b28k
Meeker, Daniella; Jiang, Xiaoqian; Matheny, Michael E; Farcas, Claudiu; D'Arcy, Michel; Pearlman, Laura; et al.(2015). A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research.. JAMIA, 22, 1187-1195. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6kj7f634

Background Centralized and federated models for sharing data in research networks currently exist. To build multivariate data analysis for centralized networks, transfer of patient-level data to a central computation resource is necessary. The author

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3660bf98a96ef4685a54c75c374723
https://doi.org/10.1093/jamia/ocv017

Isoform-specific targeting of PKA to multivesicular bodies

Autor: Mark H. Ellisman, Mira Sastri, John D. Scott, Susan S. Taylor, Mason R. Mackey, Michele E. Day, Guido M. Gaietta, Antonius Koller, Guy Perkins

Publikováno v: The Journal of Cell Biology

PKA RIα subunit is localized to MVBs by the A-kinase–anchoring protein AKAP11 when disassociated from the PKA catalytic subunit.
Although RII protein kinase A (PKA) regulatory subunits are constitutively localized to discrete cellular compart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f138607be65500ac1e1a35ba907e5473
http://europepmc.org/articles/PMC3080257

A kinase interacting protein (AKIP1) is a key regulator of cardiac stress

Autor: Heidi N. Fridolfsson, Antonius Koller, J. Cameron Finley, Daniel Ng, Susanna Petrosyan, Hemal H. Patel, Donald K. Blumenthal, Mathivadhani Panneerselvam, Sameh S. Ali, Kristofer J. Haushalter, Manjula Darshi, Jan M. Schilling, Michele E. Day, Susan S. Taylor, Hiro Hakozaki, Philip Chang, David M. Roth, Atsushi Miyanohara, Mira Sastri, Charles C. King

Publikováno v: Proceedings of the National Academy of Sciences. 110

cAMP-dependent protein kinase (PKA) regulates a myriad of functions in the heart, including cardiac contractility, myocardial metabolism,and gene expression. However, a molecular integrator of the PKA response in the heart is unknown. Here, we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968adb88740c94326fd807feb008efce
https://doi.org/10.1073/pnas.1221670110

iDASH: integrating data for analysis, anonymization, and sharing

Autor: Lucila, Ohno-Machado, Vineet, Bafna, Aziz A, Boxwala, Brian E, Chapman, Wendy W, Chapman, Kamalika, Chaudhuri, Michele E, Day, Claudiu, Farcas, Nathaniel D, Heintzman, Xiaoqian, Jiang, Hyeoneui, Kim, Jihoon, Kim, Michael E, Matheny, Frederic S, Resnic, Staal A, Vinterbo, Alex, Zambon

Publikováno v: Journal of the American Medical Informatics Association : JAMIA. 19(2)

iDASH (integrating data for analysis, anonymization, and sharing) is the newest National Center for Biomedical Computing funded by the NIH. It focuses on algorithms and tools for sharing data in a privacy-preserving manner. Foundational privacy techn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08585f28840fd703ad1388734c9fa37b
https://pubmed.ncbi.nlm.nih.gov/22081224

Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo

Autor: N. S. Day, Raj Kumar Pandita, Katarina Persson, Michele E. Day, Karl-Erik Andersson, George J. Christ, Weixin Zhao

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 284(5)

Bladder overactivity associated with outflow obstruction is a common human condition recapitulated in the female rat by narrowing the diameter of the urethra. The goal of these studies was to evaluate the role of intercellular communication through c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e921488be243924f3362d9035bbb8bf6
https://pubmed.ncbi.nlm.nih.gov/12676745