Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michele E Murphy"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Using lentiviral vector products in clinical applications requires an accurate method for measuring transduction titer. For vectors lacking a marker gene, quantitative polymerase chain reaction is used to evaluate the number of vector DNA copies in t
Externí odkaz:
https://doaj.org/article/078ee2b5a8e84bdca9a5a10fd47e457c
Autor:
Philip Bradley, Robert K. Bradley, Aravind Ramakrishnan, Ahmad S. Zebari, Brian Hayes, Janine O. Ilagan, Michele E. Murphy
Publikováno v:
Genome Research. 25:14-26
Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3′ splice site recognition fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3dd7c178833a70d312ba588beb5cfb
https://doi.org/10.1101/gr.181016.114
https://doi.org/10.1101/gr.181016.114
Autor:
Tsai-Yu Lin, Anshika Bajaj, Lisa Y. Ngo, Peter Berglund, Wayne R Gombotz, Jan ter Meulen, Brenna Kelley-Clarke, Michele E Murphy
Publikováno v:
Cancer Research. 78:5919-5919
Background: ZVex is a novel, integration-deficient, dendritic cell-targeting lentiviral vector platform currently being evaluated in clinical trials in sarcoma patients. The vector is capable of delivering multiple full-length genes simultaneously. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad784e17badf901f83872ed742408b4f
https://doi.org/10.1158/1538-7445.am2018-5919
https://doi.org/10.1158/1538-7445.am2018-5919
Autor:
Frédéric H.-T. Allain, Eunhee Kim, Silvia Buonamici, Aravind Ramakrishnan, Jean Baptiste Micol, Ahmad S. Zebari, Young Rock Chung, Omar Abdel-Wahab, H. Joachim Deeg, Robert K. Bradley, Pete Smith, Stanley Chun-Wei Lee, Iannis Aifantis, Yorgo Modis, Michele E. Murphy, Yang Liang, Camille Lobry, Janine O. Ilagan, Shlomzion Aumann, Min Kyung Kim, Yue Li, Gerrit M. Daubner, Christopher Y. Park, Hana Cho, Stephanie Halene
SummaryMutations affecting spliceosomal proteins are the most common mutations in patients with myelodysplastic syndromes (MDS), but their role in MDS pathogenesis has not been delineated. Here we report that mutations affecting the splicing factor S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aaf25258c1d7cf7f78ae59079fd442
https://www.repository.cam.ac.uk/handle/1810/254256
https://www.repository.cam.ac.uk/handle/1810/254256
Autor:
Michele E. Murphy, Robert K. Bradley, Brian Hayes, Aravind Ramakrishnan, Janine O. Ilagan, Ahmad S. Zebari, Philip Bradley
Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e002b453ba46b7977ee8b52e3cebe4
https://doi.org/10.1101/001107
https://doi.org/10.1101/001107
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Using lentiviral vector products in clinical applications requires an accurate method for measuring transduction titer. For vectors lacking a marker gene, quantitative polymerase chain reaction is used to evaluate the number of vector DNA copies in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278b7013b0c42269f1f9558c0fd10b22
https://doi.org/10.1038/mtm.2016.5
https://doi.org/10.1038/mtm.2016.5
Autor:
Peter Smith, Aravind Ramakrishnan, Iannis Aifantis, Michele E. Murphy, Jean-Baptiste Micol, Eunhee Kim, Robert K. Bradley, Ahmad S. Zebari, Stanley Chun-Wei Lee, Min Kyung Kim, Camille Lobry, Young Rock Chung, Omar Abdel-Wahab, Janine O. Ilagan, H. Joachim Deeg, Silvia Buonamici
Publikováno v:
Clinical Cancer Research. 21:IA36-IA36
Spliceosomal mutations account for the most frequent class of mutations in patients with myelodysplastic syndromes, yet the mechanism by which these mutations perform their driver function is not well understood. Given the genetic heterogeneity of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a1a35f11251beac580466f57cb19f80
https://doi.org/10.1158/1557-3265.hemmal14-ia36
https://doi.org/10.1158/1557-3265.hemmal14-ia36
Autor:
Michele E. Murphy, Aravind Ramakrishnan, Robert K. Bradley, Brian Hayes, Philip Bradley, Janine O. Ilagan, Ahmad S. Zebari
Publikováno v:
Blood. 124:1889-1889
Mutations affecting the spliceosomal protein U2AF1 are among the most common mutations observed in patients with MDS and related disorders. However, it is unclear how these mutations affect the normal RNA splicing process, and how the resulting chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1b790bdf91491b018d87d734594bd6e
https://doi.org/10.1182/blood.v124.21.1889.1889
https://doi.org/10.1182/blood.v124.21.1889.1889
SRSF2 Mutations Impair Hematopoietic Differentiation By Altering Exonic Splicing Enhancer Preference
Autor:
Eunhee Kim, Pete Smith, Aravind Ramakrishnan, Iannis Aifantis, Min Kyung Kim, Silvia Buonamici, Jean-Baptiste Micol, Jacob Feala, Young Rock Chung, Omar Abdel-Wahab, Robert K. Bradley, Ahmad S. Zebari, Stanley Chun-Wei Lee, Michele E. Murphy, Janine O. Ilagan, Camille Lobry, H. Joachim Deeg
Publikováno v:
Blood. 124:824-824
Spliceosomal mutations account for the most frequent class of mutations in patients with MDS and CMML, yet the mechanism by which these mutations perform their driver function is not well understood. Moreover, no genetically engineered murine models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::163976237f783edcecc034dc9ad41142
https://doi.org/10.1182/blood.v124.21.824.824
https://doi.org/10.1182/blood.v124.21.824.824