Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Michele D. Sobolewski"'
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
SARS-CoV-2 variants have accumulated multiple defining mutations within their spike glycoproteins. Here, the authors report a structural basis for broad neutralization of several variants by a heavy chain antibody fragment and provide a mutational an
Externí odkaz:
https://doaj.org/article/8507bc9f2a6c4b9e85210fb73299d3d4
Autor:
Chuan Chen, James W. Saville, Michelle M. Marti, Alexandra Schäfer, Mary Hongying Cheng, Dhiraj Mannar, Xing Zhu, Alison M. Berezuk, Anupam Banerjee, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Nathan Enick, Kevin D. McCormick, Xianglei Liu, Cynthia Adams, Margaret Grace Hines, Zehua Sun, Weizao Chen, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Ralph S. Baric, Ivet Bahar, Dimiter S. Dimitrov, Sriram Subramaniam, David R. Martinez, Wei Li
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104798- (2022)
Summary: The emergence of SARS-CoV-2 variants of concern (VOCs) requires the development of next-generation biologics with high neutralization breadth. Here, we characterized a human VH domain, F6, which we generated by sequentially panning large pha
Externí odkaz:
https://doaj.org/article/e9a8e86720ca420e9915a6296aa53a18
Autor:
P. Nathan Enick, Joseph P. Brooker, Camille M. Tumiotto, Brittany T. Staines, Joseph J. Eron, Deborah K. McMahon, Rajesh T. Gandhi, John W. Mellors, Michele D. Sobolewski
Publikováno v:
Journal of Virus Eradication, Vol 7, Iss 2, Pp 100043- (2021)
The quantitative viral outgrowth assay (qVOA) is the gold standard for measuring inducible, replication-competent HIV-1. Using MOLT4-R5 and SupT1-R5 cell lines instead of allogeneic blasts and HIV-1 RNA detection rather than p24 enzyme-immunoassay (E
Externí odkaz:
https://doaj.org/article/e18876d0e0a345828a73d0821fe4f652
Autor:
Andrew Musick, Jonathan Spindler, Eli Boritz, Liliana Pérez, Daniel Crespo-Vélez, Sean C. Patro, Michele D. Sobolewski, Michael J. Bale, Carolyn Reid, Brandon F. Keele, Adam Capoferri, Wei Shao, Ann Wiegand, Francesco R. Simonetti, John W. Mellors, Stephen H. Hughes, John M. Coffin, Frank Maldarelli, Mary F. Kearney
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
BackgroundHIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common. One such clone,
Externí odkaz:
https://doaj.org/article/09e396ddb33c496a8aca76083767d12b
Autor:
Ghady Haidar, Jana L Jacobs, Kailey Hughes Kramer, Asma Naqvi, Amy Heaps, Urvi Parikh, Kevin D McCormick, Michele D Sobolewski, Mounzer Agha, Tatiana Bogdanovich, Vasilii Bushunow, Rafic Farah, Matthew Hensley, Yen-Michael S Hsu, Bruce Johnson, Cynthia Klamar-Blain, Jennifer Kozar, Elizabeth Lendermon, Bernard J C Macatangay, Christopher C Marino, Anastasios Raptis, Erin Salese, Fernanda P Silveira, Ann M Leen, William L Marshall, Michael Miller, Badrish Patel, Ercem Atillasoy, John W Mellors
Publikováno v:
Clinical Infectious Diseases.
We administered severe acute respiratory syndrome coronavirus-2 viral-specific T cells (VSTs) under emergency investigational new drug applications to 6 immunocompromised patients with persistent coronavirus disease 2019 (COVID-19) and characterized
Autor:
Octavia M. Peck Palmer, Amy Lukanski, P. Nathan Enick, Alan Wells, Jana L. Jacobs, Michele D. Sobolewski, David A. Nace, April L. Kane, Kevin E. Kip, Melissa Crandall, John W. Mellors, Paula L Kip, Katie Mulvey, Kevin D. McCormick, Michael R. Shurin
Publikováno v:
Journal of the American Medical Directors Association
Objective COVID-19 disproportionately impacts residents in long-term care facilities. Our objective was to quantify the presence and magnitude of antibody response in vaccinated, older adult residents at assisted living, personal care, and independen
Autor:
Mary Ann Checkley, Benjamin G. Luttge, Curtis Dobrowolski, David N. Wald, Deborah McMahon, Ghady Haidar, Michele D. Sobolewski, P. Nathan Enick, Joshua Cyktor, John W. Mellors, Jonathan Karn
Treatment with latency-reversing agents (LRAs) alone has been ineffective in reducing HIV-1 reservoirs in persons with HIV-1 (PWH) on antiretroviral therapy (ART), due to inefficiencies in reservoir reactivation and adaptive immune responses. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe83ac9c1d4981b9c3f9a34df02c8a6
https://doi.org/10.1101/2022.09.05.506592
https://doi.org/10.1101/2022.09.05.506592
Autor:
Amy L. Heaps, Michele D. Sobolewski, Jana L. Jacobs, Kelley C. Gordon, Ghady Haidar, John W. Mellors, Urvi M. Parikh
Publikováno v:
Journal of Virological Methods. 316:114726
Autor:
Chuan Chen, James W. Saville, Michelle M. Marti, Alexandra Schäfer, Mary Hongying Cheng, Dhiraj Mannar, Xing Zhu, Alison M. Berezuk, Anupam Banerjee, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Nathan Enick, Kevin D McCormick, Xianglei Liu, Cynthia Adams, Margaret Grace Hines, Zehua Sun, Weizao Chen, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Ralph S. Baric, Ivet Bahar, Dimiter S. Dimitrov, Sriram Subramaniam, David R. Martinez, Wei Li
The emergence of SARS-CoV-2 variants of concern (VOCs) requires the development of next-generation biologics that are effective against a variety of strains of the virus. Herein, we characterize a human VH domain, F6, which we generated by sequential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c22cbb1f80d7e11bf83d1b70fe6a83
https://doi.org/10.1101/2022.02.18.481058
https://doi.org/10.1101/2022.02.18.481058
Autor:
Joshua C. Cyktor, Jason W. Rausch, Wei Shao, Camille Tumiotto, Elias K. Halvas, Michael J. Bale, John W. Mellors, Mary F. Kearney, John M. Coffin, Michele D. Sobolewski, John K. Bui, Jana L. Jacobs, Shuang Guo, Leah D. Brandt, Kevin W. Joseph, Brandon F. Keele, Stephen H. Hughes, Xiaolin Wu, Gene D. Morse
Publikováno v:
J Clin Invest
BACKGROUNDHIV-1 viremia that is not suppressed by combination antiretroviral therapy (ART) is generally attributed to incomplete medication adherence and/or drug resistance. We evaluated individuals referred by clinicians for nonsuppressible viremia