What’s new in flow biocatalysis? A snapshot of 2020–2022

Autor: Michele Crotti, Marina S. Robescu, Juan M. Bolivar, Daniela Ubiali, Lorena Wilson, Martina L. Contente

Publikováno v: Frontiers in Catalysis, Vol 3 (2023)

Flow biocatalysis is a key enabling technology that is increasingly being applied to a wide array of reactions with the aim of achieving process intensification, better control of biotransformations, and minimization of waste stream. In this mini-rev

Externí odkaz: https://doaj.org/article/9cf57bdcc3f8472da124b2c6f776c68a

Selective Colorimetric 'Turn-On' Probe for Efficient Engineering of Iminium Biocatalysis

Autor: Lieuwe Biewenga, Michele Crotti, Mohammad Saifuddin, Gerrit J. Poelarends

Publikováno v: ACS Omega, Vol 5, Iss 5, Pp 2397-2405 (2020)

Externí odkaz: https://doaj.org/article/b8ab98f832994d53a619c7416cc765b6

One-Pot Multi-Enzymatic Synthesis of the Four Stereoisomers of 4-Methylheptan-3-ol

Autor: Elisabetta Brenna, Michele Crotti, Francesco G. Gatti, Daniela Monti, Fabio Parmeggiani, Andrea Pugliese

Publikováno v: Molecules, Vol 22, Iss 10, p 1591 (2017)

The use of pheromones in the integrated pest management of insects is currently considered a sustainable and environmentally benign alternative to hazardous insecticides. 4-Methylheptan-3-ol is an interesting example of an insect pheromone, because i

Externí odkaz: https://doaj.org/article/54b0116206ba44e386568c2b056e8a5a

Comprehensive Structure–Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C–H Functionalization

Autor: Michele Crotti, Simone Giovani, Hanan Alwaseem, Rudi Fasan, Sina Ghaemmaghami, Craig T. Jordan, Kevin A. Welle

Publikováno v: ACS Central Science, Vol 7, Iss 5, Pp 841-857 (2021)
ACS Central Science

The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931d37ad086c74d1c0b734d4a9cd4fc3
https://doaj.org/article/7fb1f4907aaf4ca48e778ec8357799ef

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C‐C Bond‐Forming Enzyme

Autor: Guangcai Xu, Andreas Kunzendorf, Michele Crotti, Henriëtte J. Rozeboom, Andy‐Mark W. H. Thunnissen, Gerrit J. Poelarends

Publikováno v: Angewandte Chemie International Edition, 61(8):e202113970. WILEY-V C H VERLAG GMBH
'Angewandte Chemie International Edition ', vol: 61, pages: e202113970-1-e202113970-6 (2022)

Gene duplication and fusion are among the primary natural processes that generate new proteins from simpler ancestors. Here we adopted this strategy to evolve a promiscuous homohexameric 4-oxalocrotonate tautomerase (4-OT) into an efficient biocataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a269be443827118e8ee6e7e3fca4a9
https://research.rug.nl/en/publications/2a30ff9f-d97f-4325-922f-6af314df4551