Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michele Callejo"'
Autor:
Bryson Rast, Alexandre J. Buckmelter, Li Ren, Walter C. Voegtli, Greg Miknis, Robert J. Ely, Tony Morales, Guy Vigers, Nikole Randolph, Ellen R. Laird, Michele Callejo, Joseph P. Lyssikatos, Sarah Galbraith, Matthew Martinson, Stephen T. Schlachter, Barbara J. Brandhuber, Steve Wenglowsky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1243-1247
The development of inhibitors of B-Raf(V600E) serine-threonine kinase is described. Various head-groups were examined to optimize inhibitor activity and ADME properties. Several of the head-groups explored, including naphthol, phenol and hydroxyamidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73adb84e1114bda90d7b78517b2d0ef5
https://doi.org/10.1016/j.bmcl.2010.12.061
https://doi.org/10.1016/j.bmcl.2010.12.061
Autor:
Barbara J. Brandhuber, George T. Topalov, Michele Callejo, Matthew Martinson, Nikole Randolph, Susan L. Gloor, Ellen R. Laird, Brad Newhouse, Mike Welch, Joseph P. Lyssikatos, Joshua D. Hansen, Jonas Grina, Rich Woessner, Alan G. Olivero, Guy Vigers, Nicole M Littman, Tony Morales
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4692-4695
Herein we describe a novel pyrazole-based class of ATP competitive B-Raf inhibitors. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. A subset of these inhibitors has demonstrated the ability to inhibit downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01679be6189825d6dd1ca0c8f7d6aab9
https://doi.org/10.1016/j.bmcl.2008.07.002
https://doi.org/10.1016/j.bmcl.2008.07.002
Autor:
George T. Topalov, Laurence E. Burgess, Sumeet Rana, Fred P. Marmsater, Robert Kirk Delisle, April Cox, Shelley Allen, Stephen T. Schlachter, Nathalie Klopfenstein, Richard Woessner, Andrew Allen, Michele Callejo, Julie M. Hicks, James P. Rizzi, Robinson John E, Hicken Erik James, Joseph P. Lyssikatos, Nicholas C. Kallan, Qian Zhao, Eugene Tarlton, Mark C. Munson
The in silico construction of a PDGFRβ kinase homology model and ensuing medicinal chemistry guided by molecular modeling, led to the identification of potent, small molecule inhibitors of PDGFR. Subsequent exploration of structure–activity relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390861ebc8a2415d12f03efda9c4db14
https://europepmc.org/articles/PMC4027622/
https://europepmc.org/articles/PMC4027622/
Autor:
Stacie Bell, Alicia Neitzel, Courtney Nugent, Nathalie Klopfenstein, Christine Eberhardt, Michele Callejo, Rebecca Burris, Jennifer Regensburger, Julie Brothers, Jason Neale, Laura Hayter, Carolina Ahrendt, David Chantry, Stephen Miller, Debra Mandarino, Niti Goel
Publikováno v:
B33. ASTHMA THERAPY: NOVEL APPROACHES.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc07250c2dd93563d72006f246d869ce
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2756
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2756
Autor:
Matthew Martinson, George T. Topalov, Michele Callejo, Mike Welch, Nikole Randolph, Rich Woessner, Joseph P. Lyssikatos, Ellen R. Laird, Guy Vigers, Sarah Galbraith, Barbara J. Brandhuber, Jonas Grina, Joshua D. Hansen, Brad Newhouse, Nicole M Littman, Alan G. Olivero, Tony Morales
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(11)
The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d2ef9017c0890fcfd275c77fdaaee5
https://pubmed.ncbi.nlm.nih.gov/21536432
https://pubmed.ncbi.nlm.nih.gov/21536432
Autor:
Li Ren, Tony Morales, Matthew Martinson, Jonas Grina, Guy Vigers, Joseph P. Lyssikatos, Michele Callejo, Greg Miknis, Mike Welch, Bryson Rast, Barbara J. Brandhuber, Eugene Tarlton, Nikole Randolph, Ellen R. Laird, Stephen T. Schlachter, Steve Wenglowsky, Alexandre J. Buckmelter
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(4)
Virtual and high-throughput screening identified imidazo[1,2-a]pyrazines as inhibitors of B-Raf. We describe the rationale, SAR, and evolution of the initial hits to a series of furo[2,3-c]pyridine indanone oximes as highly potent and selective inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ecb177a764a3a1498267492422d893
https://pubmed.ncbi.nlm.nih.gov/21211972
https://pubmed.ncbi.nlm.nih.gov/21211972
Autor:
Brandon Willis, Anna Gomez, Patrice Lee, Robert Kirk Delisle, Christine Lemieux, Boys Mark Laurence, Qian Zhao, Laurence E. Burgess, Walter E. DeWolf, Bryson Rast, Kennedy April L, Deborah J. Anderson, Matthew Martinson, Mark C. Munson, James P. Rizzi, Stefan Gross, Tyler Risom, Martha Rodriguez, Michele Callejo, Albion D. Wright, Jason R. Neale, George T. Topalov
Publikováno v:
Cancer Research. 71:551-551
Increasing evidence suggests that interactions between tumor cells, stromal cells, macrophages and the extracellular matrix are pivotal to the processes of tumorigenesis, metastasis, and neovascularization. Macrophages within the tumor microenvironme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab1cd4223ebb43b3cdf953f0f6ae4735
https://doi.org/10.1158/1538-7445.am2011-551
https://doi.org/10.1158/1538-7445.am2011-551