Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michele Brogley"'
Autor:
Diane M. Robins, Haniya Rehman, Michele Brogley, Megan A. Albertelli, Mara P. Steinkamp, Orla A. O'Mahony
Gain-of-function mutations in the androgen receptor (AR) are found in prostate cancer and are implicated in the failure of hormone therapy. Most studies have emphasized the ligand-binding domain (LBD) where mutations can create promiscuous receptors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ece546e3d35ffcfdca6b7db865316f5
https://doi.org/10.1158/1541-7786.c.6541447.v1
https://doi.org/10.1158/1541-7786.c.6541447.v1
Autor:
Diane M. Robins, Haniya Rehman, Michele Brogley, Megan A. Albertelli, Mara P. Steinkamp, Orla A. O'Mahony
Supplementary Tables S1-S2 from Profiling Human Androgen Receptor Mutations Reveals Treatment Effects in a Mouse Model of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e12050e09343ce0620af085e8321a4e
https://doi.org/10.1158/1541-7786.22516693
https://doi.org/10.1158/1541-7786.22516693
Autor:
Diane M. Robins, Kenneth J. Pienta, Mark A. Rubin, Arul Chinnaiyan, Rainer Kuefer, Matthias D. Hofer, Saravana Dhanasekaran, Elizabeth W. LaPensee, Haniya Rehman, Michele Brogley, Orla A. O'Mahony, Mara P. Steinkamp
Supplementary Figure 2 from Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0456cd82e064803071fe4e8f6de20ab0
https://doi.org/10.1158/0008-5472.22378194
https://doi.org/10.1158/0008-5472.22378194
Autor:
Diane M. Robins, Kenneth J. Pienta, Mark A. Rubin, Arul Chinnaiyan, Rainer Kuefer, Matthias D. Hofer, Saravana Dhanasekaran, Elizabeth W. LaPensee, Haniya Rehman, Michele Brogley, Orla A. O'Mahony, Mara P. Steinkamp
Supplementary Figure 1 from Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aed770ee61f9c91a8d96618aae8851
https://doi.org/10.1158/0008-5472.22378197
https://doi.org/10.1158/0008-5472.22378197
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 1997-2005 (2020)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Mouse sex chromosomes are enriched for co-amplified gene families, present in tens to hundreds of copies. Co-amplification of Slx/Slxl1 on the X chromosome and Sly on the Y chromosome are involved in dose-dependent meiotic drive, however the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a13d3e97d82a8fdd52cdeddd9ec252
http://g3journal.org/lookup/doi/10.1534/g3.120.401221
http://g3journal.org/lookup/doi/10.1534/g3.120.401221
Autor:
Diane M. Robins, Marcin Cieslik, Pia Bagamasbad, Elizabeth LaPensee, Shihan He, Steven Kregel, Michele Brogley, Arul M. Chinnaiyan, Yemi Raji
Publikováno v:
Nucleic Acids Research
Androgen receptor (AR) action is a hallmark of prostate cancer (PCa) with androgen deprivation being standard therapy. Yet, resistance arises and aberrant AR signaling promotes disease. We sought compounds that inhibited genes driving cancer but not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea722ccf972fb794d0baeff9ea930f7e
https://doi.org/10.1093/nar/gkaa178
https://doi.org/10.1093/nar/gkaa178
Mouse sex chromosomes are enriched for co-amplified gene families, present in tens to hundreds of copies. Co-amplification of Slx/Slxl1 on the X chromosome and Sly on the Y chromosome are involved in dose-dependent genetic conflict, however the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d700bd7271180e388cca6f836f30a22c
https://doi.org/10.1101/2020.01.08.898924
https://doi.org/10.1101/2020.01.08.898924
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5385d2842055a5272fdd9d1217e1b06
https://doi.org/10.1038/s41598-018-27360-x
https://doi.org/10.1038/s41598-018-27360-x
Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, at a time when most single-copy sex-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268e097085ddee3ea9a9b99c493dc94d
https://doi.org/10.1101/245860
https://doi.org/10.1101/245860
Autor:
Yueh-Chiang Hu, Alyssa N. Kruger, Jamie L. Huizinga, Dirk G. de Rooij, Jeffrey M. Kidd, Michele Brogley, Jacob L. Mueller
Publikováno v:
Current Biology, 29(21), 3699. Cell Press
Curr Biol
Current biology, 29(21), 3699-3706.e5. Cell Press
Curr Biol
Current biology, 29(21), 3699-3706.e5. Cell Press
Summary The mammalian sex chromosomes harbor an abundance of newly acquired ampliconic genes, although their functions require elucidation [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Here, we demonstrate that the X-linked Slx and Slxl1 ampliconic gene fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce87b8f1b84f9d8a5007a4f29b843470
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074069084&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074069084&origin=inward