Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michele Bonus"'
Autor:
Sezin Yüksel, Michele Bonus, Tina Schwabe, Christopher Pfleger, Thomas Zimmer, Uta Enke, Inga Saß, Holger Gohlke, Klaus Benndorf, Jana Kusch
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to th
Externí odkaz:
https://doaj.org/article/9fd4821d4e2641c9a8abc668af73cd8c
Autor:
Julia Sachs, Katja Döhl, Anja Weber, Michele Bonus, Ferdinand Ehlers, Edmond Fleischer, Anette Klinger, Holger Gohlke, Jörg Pietruszka, Lutz Schmitt, Nicole Teusch
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the efficacious treatment of patients by reduction of therapy options and subsequent treatment failure. Various mechanisms are described to be involved in the development o
Externí odkaz:
https://doaj.org/article/34ae5ab8192f4c63aca732d51ee02abb
Publikováno v:
Chembiochem
ChemBioChem 21(16), 2311-2320 (2020). doi:10.1002/cbic.202000116
ChemBioChem 21(16), 2311-2320 (2020). doi:10.1002/cbic.202000116
High‐affinity fluorescent derivatives of cyclic adenosine and guanosine monophosphate are powerful tools for investigating their natural targets. Cyclic nucleotide‐regulated ion channels belong to these targets and are vital for many signal trans
Autor:
Sezin, Yüksel, Michele, Bonus, Tina, Schwabe, Christopher, Pfleger, Thomas, Zimmer, Uta, Enke, Inga, Saß, Holger, Gohlke, Klaus, Benndorf, Jana, Kusch
Publikováno v:
Frontiers in physiology 13, 895324 (2022). doi:10.3389/fphys.2022.895324
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1d4b9f86be4485904f668ad264ad20d
https://hdl.handle.net/2128/31813
https://hdl.handle.net/2128/31813
Autor:
Michele Bonus, Jana Kusch, Frank Schwede, Tim Leypold, Tina Schwabe, Holger Gohlke, Felix Spiegelhalter
Publikováno v:
J Biol Chem
The journal of biological chemistry 294, 17978-17987 (2019). doi:10.1074/jbc.RA119.010246
The journal of biological chemistry 294, 17978-17987 (2019). doi:10.1074/jbc.RA119.010246
cAMP acts as a second messenger in many cellular processes. Three protein types mainly mediate cAMP-induced effects: PKA, exchange protein directly activated by cAMP (Epac), and cyclic nucleotide–modulated channels (cyclic nucleotide–gated or hyp
Autor:
Eckhard Schulz, Michele Bonus, Christian Sattler, Thomas Zimmer, Melanie Wiegand, Ralf Schmauder, Klaus Benndorf, Nisa Kosmalla, Holger Gohlke, Taulant Kukaj, Thomas Eick, Gunter Ehrlich, Tina Schwabe, Jan L. Münch, Jana Schirmeyer, Sabine Hummert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118
Significance Membrane receptors control innumerous essential functions of living cells and are proven drug targets for pharmacological interventions. Many receptors are composed of a number of subunits and contain multiple binding sites for ligands,
Autor:
Birgit Budde, Mila Beyer, Jörg Schipper, Birgit Lorenz, Boris Görg, Ulrich Zechner, Hans-Jörg Wittsack, Diran Herebian, Christopher Pfleger, Hanno J. Bolz, Janine Altmüller, Jörg Schaper, Natalia Qvartskhava, Markus N. Preising, Dieter Häussinger, Alfons Schnitzler, Holger Gohlke, Mohammad R. Toliat, Peter Nürnberg, Christoph Friedburg, Michele Bonus, Helge J. Zöllner, Dirk Klee
Publikováno v:
The FASEB Journal. 33:11507-11527
We previously reported that inactivation of the transmembrane taurine transporter (TauT or solute carrier 6a6) causes early retinal degeneration in mice. Compatible with taurine’s indispensability ...
Autor:
Michele Bonus, Kai Stühler, L Zhao, Dieter Häussinger, Gereon Poschmann, Holger Gohlke, Tom Luedde, Boris Görg
Publikováno v:
37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber.
Publikováno v:
Biological chemistry 402(9), 1033-1045 (2021). doi:10.1515/hsz-2021-0193
Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26211dd68584da4fa9b7c9d71edd133
https://hdl.handle.net/2128/28508
https://hdl.handle.net/2128/28508
Autor:
Swastik Mishra, Nicoline M. Gappel, Michele Bonus, Andrey V. Malkovskiy, Michael M. Wudick, Martin J. Lercher, Debarati Basu, Elizabeth S. Haswell, Stephan Schott-Verdugo, Thomas J. Kleist, Mackenzie Machado, David W. Ehrhardt, Margaret Bezrutczyk, Wolf B. Frommer, Cosima S. A. Sies, Holger Gohlke, Edward E. Farmer, Thomas Hartwig, Jacob Moe-Lange
Publikováno v:
Science advances 7(37), eabg4298 (2021). doi:10.1126/sciadv.abg4298
Glutamate has dual roles in metabolism and signaling; thus, signaling functions must be isolatable and distinct from metabolic fluctuations, as seen in low-glutamate domains at synapses. In plants, wounding triggers electrical and calcium (Ca 2+ ) si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1840c5aa4c81f9cba06b3795ee7b9c3e
https://hdl.handle.net/2128/28626
https://hdl.handle.net/2128/28626