Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Michele Ardolino"'
Autor:
Frederic St‐Denis‐Bissonnette, Shirley Qiu, Sarah E. Cummings, Melanie Kirkby, Yohannes Haile, Sarah Wassmer, Gauri Muradia, Jelica Mehic, Andrew Stalker, Amit Shrestha, Michele Ardolino, Seung‐Hwan Lee, Dylan Burger, Lisheng Wang, Jessie R. Lavoie
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 7, Pp n/a-n/a (2024)
Abstract Natural killer cell‐derived extracellular vesicles (NK‐EVs) are candidate biotherapeutics against various cancers. However, standardised potency assays are necessary for a reliable assessment of NK‐EVs' cytotoxicity. This study aims to
Externí odkaz:
https://doaj.org/article/e9c74a4ae6444282ad687844f70ffab3
Autor:
Kristianne J. C. Galpin, Galaxia M. Rodriguez, Vincent Maranda, David P. Cook, Elizabeth Macdonald, Humaira Murshed, Shan Zhao, Curtis W. McCloskey, Andrzej Chruscinski, Gary A. Levy, Michele Ardolino, Barbara C. Vanderhyden
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The tumour microenvironment is infiltrated by immunosuppressive cells, such as regulatory T cells (Tregs), which contribute to tumour escape and impede immunotherapy outcomes. Soluble fibrinogen-like protein 2 (sFGL2), a Treg effector protei
Externí odkaz:
https://doaj.org/article/9b0eedb8063c45d7aa50b8761ac3582f
Autor:
Karan Mediratta, Sara El-Sahli, Marie Marotel, Muhammad Z. Awan, Melanie Kirkby, Ammar Salkini, Reem Kurdieh, Salman Abdisalam, Amit Shrestha, Chiara Di Censo, Andrew Sulaiman, Sarah McGarry, Jessie R. Lavoie, Zhen Liu, Seung-Hwan Lee, Xuguang Li, Giuseppe Sciumè, Vanessa M. D’Costa, Michele Ardolino, Lisheng Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChemotherapy remains the mainstay treatment for triple-negative breast cancer (TNBC) due to the lack of specific targets. Given a modest response of immune checkpoint inhibitors in TNBC patients, improving immunotherapy is an urgent and c
Externí odkaz:
https://doaj.org/article/10213cd0c20d41adb4e2783bba54bf80
Autor:
Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abolfazl Nik-Akhtar, Mahsa Ahmadi, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow, John C. Bell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral replication as well as timing and dosing of transgene expression in order to facilitate safe
Externí odkaz:
https://doaj.org/article/ac9b0514948d4425b5c222c2feb15ba2
Autor:
Marisa K. Kilgour, Donald J. Bastin, Seung-Hwan Lee, Michele Ardolino, Scott McComb, Alissa Visram
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Advancements in chimeric antigen receptor engineered T-cell (CAR-T) therapy have revolutionized treatment for several cancer types over the past decade. Despite this success, obstacles including the high price tag, manufacturing complexity, and treat
Externí odkaz:
https://doaj.org/article/d6af72ff1fde46dbac7e6d107277a392
Autor:
John Abou-Hamad, Jonathan J. Hodgins, Edward Yakubovich, Barbara C. Vanderhyden, Michele Ardolino, Luc A. Sabourin
Publikováno v:
Cells, Vol 13, Iss 1, p 73 (2023)
Targeted therapy resistance frequently develops in melanoma due to intratumor heterogeneity and epigenetic reprogramming. This also typically induces cross-resistance to immunotherapies. Whether this includes additional modes of therapy has not been
Externí odkaz:
https://doaj.org/article/379f6adab2d44074b070f701d04bf5df
Autor:
John Abou-Hamad, Jonathan J. Hodgins, Christiano T. de Souza, Brennan Garland, Cédrik Labrèche, Marie Marotel, Cameron Gibson, Samuel Delisle, Julia Pascoal, Rebecca C. Auer, Michele Ardolino, Luc A. Sabourin
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105524- (2022)
Summary: SOX10 is a key regulator of melanoma progression and promotes a melanocytic/differentiated state. Here we identified melanoma cell lines lacking SOX10 expression which retain their in vivo growth capabilities. More importantly, we find that
Externí odkaz:
https://doaj.org/article/627ac5f7b4ef457cb4fd187908d34dd8
Autor:
Laura Glickman, Michele Ardolino, Haixing Kehoe, Alexandre Iannello, Keith Cheung, Bret Peterson, Marie Marotel, Sara Tribble, Hailey He, Jonathan Hodgins, Christopher Rae, Christopher Thanos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/05ee349df84f43188bf289ddc4daf3b5
Autor:
Serena Cortés-Kaplan, Reem Kurdieh, Mohamed S. Hasim, Shelby Kaczmarek, Zaid Taha, Glib Maznyi, Scott McComb, Seung-Hwan Lee, Jean-Simon Diallo, Michele Ardolino
Publikováno v:
Cancers, Vol 14, Iss 12, p 2832 (2022)
Due to their crucial role in tumor immunity, NK cells have quickly became a prime target for immunotherapies, with the adoptive transfer of NK cells and the use of NK cell engagers quickly moving to the clinical stage. On the other hand, only a few s
Externí odkaz:
https://doaj.org/article/a1599de7914d4ff9b4e6044bf08dda13
Autor:
Carolyn Nessim, Jean-Simon Diallo, Harsimrat Kaur Birdi, Anna Jirovec, Serena Cortés-Kaplan, Joel Werier, Michele Ardolino
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Sarcomas are a rare malignancy of mesenchymal tissues, comprizing a plethora of unique subtypes, with more than 60 types. The sheer heterogeneity of disease phenotype makes this a particularly difficult cancer to treat. Radiotherapy, chemotherapy and
Externí odkaz:
https://doaj.org/article/e1fe72d8937549b89ab948186d980f96