Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michele A. Zacks"'
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 77, Iss 4, Pp 695-715 (2005)
There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress-induced injuries that may contribute to disease progression. Pathogen invasion- and replication-mediated cellular injuries and immune-mediated cyto
Externí odkaz:
https://doaj.org/article/ae55e2f4d95e44c1bc7bc448296d07b6
Autor:
Rebecca J. Jernigan, Dhenugen Logeswaran, Diandra Doppler, Nirupa Nagaratnam, Mukul Sonker, Jay-How Yang, Gihan Ketawala, Jose M. Martin-Garcia, Megan L. Shelby, Thomas D. Grant, Valerio Mariani, Alexandra Tolstikova, Michelle Z. Sheikh, Mimi Cho Yung, Matthew A. Coleman, Sahba Zaare, Emily K. Kaschner, Mohammad Towshif Rabbani, Reza Nazari, Michele A. Zacks, Brandon Hayes, Raymond G. Sierra, Mark S. Hunter, Stella Lisova, Alexander Batyuk, Christopher Kupitz, Sebastien Boutet, Debra T. Hansen, Richard A. Kirian, Marius Schmidt, Raimund Fromme, Matthias Frank, Alexandra Ros, Julian J.-L. Chen, Sabine Botha, Petra Fromme
Publikováno v:
Structure (London, England : 1993), vol 31, iss 2
NendoU from SARS-CoV-2 is responsible for the virus's ability to evade the innate immune system by cleaving the polyuridine leader sequence of antisense viral RNA. Here we report the room-temperature structure of NendoU, solved by serial femtosecond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bef2836b7a4046d22d1ffb3d608a55
https://doi.org/10.1016/j.str.2022.12.009
https://doi.org/10.1016/j.str.2022.12.009
Autor:
Michele A, Zacks, Slobodan, Paessler
Publikováno v:
Veterinary Microbiology. 140:281-286
This review will cover zoonotic, encephalitic alphaviruses in the family Togaviridae. Encephalitic alphaviruses, i.e. western- (WEEV), eastern- (EEEV), Venezuelan equine encephalitis virus (VEEV) and, more rarely, Ross River virus, Chikungunya virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b97a39b607f929e26a98b16f9fd5e6
https://doi.org/10.1016/j.vetmic.2009.08.023
https://doi.org/10.1016/j.vetmic.2009.08.023
Autor:
Barbara M. Judy, Bi Hung Peng, Andrea S. Bertke, D. Mark Estes, Viktoriya Borisevich, Jeanon N. Smith, Milagros Salazar, Allison Poussard, Jennifer K. Smith, Michele A. Zacks, Nadezhda E. Yun, Slobodan Paessler
Publikováno v:
Vaccine. 27:4064-4073
Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473f9c3967ee31b64db140ab6cc8ef2c
https://doi.org/10.1016/j.vaccine.2009.04.015
https://doi.org/10.1016/j.vaccine.2009.04.015
Autor:
Nathaniel S. Linde, Jeanon N. Smith, Slobodan Paessler, Nadezda Yun, Yin Chen, Harilyn McMicken, Michele A. Zacks, Jennifer K. Smith, Frédéric Kendirgi
Publikováno v:
Human Vaccines. 4:410-419
Vaccine development for possible influenza pandemics has been challenging. Conventional vaccines such as inactivated and live attenuated virus preparations are limited in terms of production speed and capacity. DNA vaccination has emerged as a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257673cf0d26697086281faf725fd36d
https://doi.org/10.4161/hv.4.6.6177
https://doi.org/10.4161/hv.4.6.6177
Autor:
Natallia Dziuba, Olga V. Chumakova, Michele A. Zacks, Nathaniel S. Linde, Jeanon N. Smith, Judy Aronson, Nadezhda E. Yun, Heather M. Lander, Slobodan Paessler, Clarence J. Peters, Jennifer K. Smith
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 79:275-282
Argentine hemorrhagic fever (AHF), a systemic infectious disease caused by infection with Junin virus, affects several organs, and patients can show hematologic, cardiovascular, renal, or neurologic symptoms. We compared the virulence of two Junin vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c04b0b1d842676c5d1b7f34bda9689f
https://doi.org/10.4269/ajtmh.2008.79.275
https://doi.org/10.4269/ajtmh.2008.79.275
Autor:
Robert E. Blouch, Viktoriya Borisevich, David A. Stein, Yinghong Ma, Slobodan Paessler, Rene Rijnbrand, Natallia Dziuba, Patrick L. Iversen, Alexey Seregin, Haolin Ni, Michele A. Zacks, Nadezhda E. Yun
Publikováno v:
Virology
The genus Alphavirus contains members that threaten human health, both as natural pathogens and as potential biological weapons. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) enter cells readily and can inhibit viral replication t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f1ce2dbb16f36fa65913cf25e9dabe
Autor:
Natallia Dziuba, Ian G. Barr, Slobodan Paessler, Lifang Zhang, Michele A. Zacks, Nathaniel S. Linde, Jeanon N. Smith, C. Shane Arnold, Nadezhda E. Yun, J. M. Kilpatrick, Aeron C. Hurt, Michael R. Holbrook
Publikováno v:
Virology. 374(1):198-209
The post-exposure therapeutic efficacy of injectable peramivir against highly pathogenic avian influenza type A H5N1 was evaluated in mice and in ferrets. Seventy to eighty percent of the H5N1-infected peramivir-treated mice, and 70% in the oseltamiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227cf71cd632620b88df41dabbeb2c63
Autor:
Michele A. Zacks, Anna H. Grund, Natallia Dziuba, Scott C. Weaver, Ilya Frolov, Gerald A. Campbell, D. Mark Estes, Nadezhda E. Yun, Slobodan Paessler, Barbara M. Judy
Publikováno v:
Virology
We evaluated the safety and immunogenicity of a chimeric alphavirus vaccine candidate in mice with selective immunodeficiencies. This vaccine candidate was highly attenuated in mice with deficiencies in the B and T cell compartments, as well as in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1fa096d9b85d906f8da56ca9d58e6c
Autor:
Jeanon N. Smith, Jennifer K. Smith, Bi Hung Peng, Jenna Linde, Nadezhda E. Yun, Slobodan Paessler, Michele A. Zacks, Seth Linde, Gerald A. Campbell, Olga V. Chumakova
Publikováno v:
Veterinary microbiology. 156(3-4)
Highly pathogenic H5N1 virus remains a potential threat to humans. Over 289 fatalities have been reported in WHO confirmed human cases since 2003, and lack of effective vaccines and early treatments contribute to increasing numbers of cases and fatal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2707ef746f2d59807bed0afcdcb799d
https://pubmed.ncbi.nlm.nih.gov/22176758
https://pubmed.ncbi.nlm.nih.gov/22176758