Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Michele A. Fahey"'
1
Alopecia in Rhesus macaques correlates with immunophenotypic alterations in dermal inflammatory infiltrates consistent with hypersensitivity etiology
Autor: Angela Carville, Keith G. Mansfield, Lynn M. Wachtman, Michele A. Fahey, Joshua A. Kramer, Rosemary V. Santos
Publikováno v: Journal of Medical Primatology. 39:112-122
Background Although alopecia is a commonly recognized problem affecting many captive Rhesus macaque colonies, there is no consensus as to the underlying etiology or appropriate course of management. Methods We performed skin biopsies to assess underl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb52cabf5e8c71f2f3af78ffd0b7212c
https://doi.org/10.1111/j.1600-0684.2010.00402.x
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2
MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor
Autor: Laurie J. Lynch, Michele A. Fahey, Ashley–Kay Fryer, Christopher D. Verrico, Gregory M. Miller, Bertha K. Madras
Publikováno v: Journal of Psychopharmacology. 22:187-202
Human MDMA (R,S-3,4-methylenedioxymethamphetamine) users display selective cognitive deficits after acute MDMA exposure, frequently attributed to serotonin deficits. We postulated that MDMA will compromize executive function in primates and that an i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dab586041d06140361cc2f4617e0fa
https://doi.org/10.1177/0269881107083639
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3
Dopamine Transporter (DAT) Inhibitors Alleviate Specific Parkinsonian Deficits in Monkeys: Association with DAT Occupancy in Vivo
Autor: Bertha K. Madras, Michele A. Fahey, Peter C. Meltzer, Alan J. Fischman, Martin Goulet, Zhicheng Lin, Ali A. Bonab, Eli Livni, David R. Elmaleh, Jacob Bendor, Claudia Goodrich
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 319:570-585
Viable dopamine neurons in Parkinson's disease express the dopamine transporter (DAT) and release dopamine (DA). We postulated that potent DAT inhibitors, with low affinity for the serotonin transporter (SERT), may elevate endogenously released extra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117b828ee2c32b82ccf17632fc7c0416
https://doi.org/10.1124/jpet.106.105312
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4
Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors
Autor: Michele A. Fahey, Susan R. George, Ali A. Bonab, Bertha K. Madras, Eli Livni, Richard De La Garza, Martin Goulet, Peter C. Meltzer, Alan J. Fischman, Brian F. O'Dowd, Roger D. Spealman, Gregory M. Miller
Publikováno v: European Journal of Pharmacology. 479:41-51
Without exception, therapeutic and addictive drugs that produce their primary effects by blocking monoamine transporters in brain contain an amine nitrogen in their structure. This fundamental canon of drug design was based on a prevailing premise th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bcd1dab72669b49386f667d310e6e7
https://doi.org/10.1016/j.ejphar.2003.08.055
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5
Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain
Autor: John W. Babich, Michele A. Fahey, Edward G. Stopa, David R. Elmaleh, Peter C. Meltzer, Alan J. Fischman, Anna Y. Liang, Lawrence M. Gracz, Bertha K. Madras
Publikováno v: Synapse. 29:116-127
Increasing evidence suggests that the dopamine transporter is situated almost exclusively on dopamine neurons. Accordingly, it is an valuable marker for Parkinson's disease and other pathological states of dopamine neurons. We previously demonstrated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27226f05376af7af6b3dce6f302a5532
https://doi.org/10.1002/(sici)1098-2396(199806)29:2<116::aid-syn3>3.0.co
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7
N-Modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors
Autor: J. K. Saha, Michele A. Fahey, D R Canfield, Bertha K. Madras, John L. Neumeyer, Richard A. Milius, Roger D. Spealman, J.B. Kamien
Publikováno v: Pharmacology Biochemistry and Behavior. 35:949-953
The binding properties of three N-modified fluorophenyltropane analogs of cocaine were compared in competition experiments with [3H]cocaine. All three analogs displaced specifically bound [3H]cocaine from caudate-putamen membranes of cynomolgus monke
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ae6e754c6ed4556b08375e2b7d38cf
https://doi.org/10.1016/0091-3057(90)90384-t
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8
The efficacy of diazepam treatment for the management of acute wounding episodes in captive rhesus macaques
Autor: Stefan, Tiefenbacher, Michele A, Fahey, James K, Rowlett, Jerrold S, Meyer, Amber L, Pouliot, Brenda M, Jones, Melinda A, Novak
Publikováno v: Comparative medicine. 55(4)
The spontaneous development of self-injurious behavior (SIB) in singly housed monkeys poses a challenge for their management and well-being in captivity. Relatively little information is available on effective treatments for SIB. This study examined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96fffceebd2845be326b329fb00e1efd
https://pubmed.ncbi.nlm.nih.gov/16158915
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9
D1and D2Dopamine Receptors in Caudate-Putamen of Nonhuman Primates (Macaca fascicularis)
Autor: Roger D. Spealman, Michele A. Fahey, Bertha K. Madras, D R Canfield
Publikováno v: Journal of Neurochemistry. 51:934-943
D1 and D2 dopamine receptors were characterized in the caudate-putamen region of nonhuman primate brains (Macaca fascicularis). D1 dopamine receptors were identified with [3H]SCH 23390 and D2 receptors with [3H]-spiperone. Scatchard analysis of [3H]S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d94a4a2eb6212c0ba8ea19101eca3c
https://doi.org/10.1111/j.1471-4159.1988.tb01830.x
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