Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michele A Melton"'
Autor:
Julia A. Guzova, Gabriel Mbalaviele, Alexander F. Shaffer, Sheri L. Bonar, John F. Schindler, David C. Thompson, Nandini Kishore, Catherine S. Tripp, Cynthia D. Sommers, Yiding Hu, Sumathy Mathialagan, Po Chang Chiang, Michele A. Melton, Lori Christine
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:14-25
Nuclear factor (NF)-kappaB activation has been clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis. The central role that IkappaB kinase-2 (IKK-2) plays in regulating NF-kappaB signaling in response to inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88dfc2562c02b4aed4c1440b261119e
https://doi.org/10.1124/jpet.108.143800
https://doi.org/10.1124/jpet.108.143800
Publikováno v:
Contemporary Family Therapy. 29:177-183
To meet the needs of clients, mental health clinics must offer responsive, organized intake procedures. Clients who receive rapid intervention when they request therapy services are more likely to attend and benefit from therapy. The present study ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4aa6c8b5916c430a76a8784cb7f7828
https://doi.org/10.1007/s10591-007-9037-z
https://doi.org/10.1007/s10591-007-9037-z
Autor:
Jane L. Wang, Michael B. Tollefson, Margaret L. Grapperhaus, James A. Sikorski, Richard C. Durley, Monica B. Norton, Michele A. Promo, Michele A. Melton, Mark A. Massa, Emily J. Reinhard, Brian S. Hickory, William F. Vernier, Mark E. Smith, Yvette M. Fobian, Karen Regina, Bryan J. Witherbee, Daniel T. Connolly
Publikováno v:
Journal of Medicinal Chemistry. 46:2152-2168
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10e457203bbb1110208e3911dfa6aac
https://doi.org/10.1021/jm020528+
https://doi.org/10.1021/jm020528+
Autor:
Michele A Melton, Nigam P. Rath, Ming Zeng, Margaret L. Grapperhaus, Brian S Hickory, Jane L Wang, Elaine S. Krul, Deborah M. Heuvelman, Mark E. Smith, Kevin C. Glenn, Richard C Durley, Deborah A. Mischke, Bryan J. Witherbee, Daniel T. Connolly, Dale P Spangler, Dorothy D. Honda, Yvette M. Fobian, James A. Sikorski, Mark A. Massa, Barry L. Parnas
Publikováno v:
Journal of Medicinal Chemistry. 45:3891-3904
A novel series of substituted N-benzyl-N-phenyl-trifluoro-3-amino-2-propanols are described that reversibly inhibit cholesteryl ester transfer protein (CETP). Starting with screening lead 22, various structural features were explored with respect to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054e4cc40c00d2928100cc032ffe6208
https://doi.org/10.1021/jm020038h
https://doi.org/10.1021/jm020038h
Autor:
Emily J, Reinhard, Jane L, Wang, Richard C, Durley, Yvette M, Fobian, Margaret L, Grapperhaus, Brian S, Hickory, Mark A, Massa, Monica B, Norton, Michele A, Promo, Michael B, Tollefson, William F, Vernier, Daniel T, Connolly, Bryan J, Witherbee, Michele A, Melton, Karen J, Regina, Mark E, Smith, James A, Sikorski
Publikováno v:
Journal of medicinal chemistry. 46(11)
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d9119f562ad78addf9a4a9fd8706b8e
https://pubmed.ncbi.nlm.nih.gov/12747787
https://pubmed.ncbi.nlm.nih.gov/12747787
Autor:
James A. Sikorski, William F. Vernier, Jeng-Jong Shieh, Michele A. Melton, Mark E. Smith, Daniel T. Connolly, Richard C. Durley, Brad R. McKinnis, Margaret L. Grapperhaus, Maribeth A. Babler, Bryan J. Witherbee
Publikováno v:
Biochemistry. 39(45)
Chiral N,N-disubstituted trifluoro-3-amino-2-propanols represent a recently discovered class of compounds that inhibit the neutral lipid transfer activity of cholesteryl ester transfer protein (CETP). These compounds all contain a single chiral cente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c49da4e23317a957a88b3d806cc692
https://pubmed.ncbi.nlm.nih.gov/11076528
https://pubmed.ncbi.nlm.nih.gov/11076528
Autor:
Edward E. Remsen, Russell E McKINNIE, Jonathan McINTYRE, Connolly Daniel T, Deborah Heuvelman, Kevin C. Glenn, Michele A. Melton, Linh Vu, Elaine S. Krul, Roger Monsell
Cholesteryl ester transfer protein (CETP) mediates the exchange of triglycerides (TGs), cholesteryl esters (CEs) and phospholipids (PLs) between lipoproteins in the plasma. In order to better understand the lipid transfer process, we have used recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c37543479281f5bf60171a2610d9e04
https://europepmc.org/articles/PMC1217895/
https://europepmc.org/articles/PMC1217895/
Autor:
Kevin C. Glenn, Michele A. Melton
Publisher Summary The assay for cholesteryl ester transfer protein (CETP) activity common to most publications consists of incubating [ 3 H] high-density lipoprotein (HDL) (1-10 μg cholesterol) and unlabeled low-density lipoprotein (LDL) (1-10μg ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23224c9ed6ae30ae8f8f0394f4fc5652
https://doi.org/10.1016/s0076-6879(96)63026-2
https://doi.org/10.1016/s0076-6879(96)63026-2
Autor:
Randall K. Rader, Jeffrey D. Peterson, Sylvie Kossodo, Thomas P. Misko, Timothy P. LaBranche, John T Listello, Mark A Abrams, Kristine O. Vasquez, Michele A. Melton
Publikováno v:
Arthritis Research & Therapy
Introduction: Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76668a1934be164644b563a5b77de3f
https://doi.org/10.1186/ar3038
https://doi.org/10.1186/ar3038