Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Michele A, Kutzler"'
Autor:
Benjamin S. Haslund-Gourley, Kyra Woloszczuk, Jintong Hou, Jennifer Connors, Gina Cusimano, Mathew Bell, Bhavani Taramangalam, Slim Fourati, Nathan Mege, Mariana Bernui, Matthew C. Altman, Florian Krammer, Harm van Bakel, IMPACC Network, Holden T. Maecker, Nadine Rouphael, Joann Diray-Arce, Brian Wigdahl, Michele A. Kutzler, Charles B. Cairns, Elias K. Haddad, Mary Ann Comunale
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not be
Externí odkaz:
https://doaj.org/article/3ec94a3f579544858deda0f8801d626a
Autor:
Jennifer Connors, Gina Cusimano, Nathan Mege, Kyra Woloszczuk, Emily Konopka, Matthew Bell, David Joyner, Jennifer Marcy, Virginie Tardif, Michele A. Kutzler, Roshell Muir, Elias K. Haddad
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023)
In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors. Significant progress has bee
Externí odkaz:
https://doaj.org/article/c0f6d54dbefc41c98846e72a4e1051a7
Autor:
Jennifer Connors, David Joyner, Nathan J. Mege, Gina M. Cusimano, Matthew R. Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M. Kim, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Michele A. Kutzler, Mohamad-Gabriel Alameh, Elias K. Haddad
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
The role of empty lipid nanoparticles in eliciting dendritic cell maturation and innate immune signaling is shown to be impaired in older adults, potentially contributing to lower immune responses to SARS-CoV-2 mRNA-based vaccines.
Externí odkaz:
https://doaj.org/article/f939a91eb95f4c4fb669b5245aa1ee19
Autor:
Ebony N. Gary, Nicholas J. Tursi, Bryce M. Warner, Gina Cuismano, Jennifer Connors, Elizabeth M. Parzych, Bryan D. Griffin, Matthew R. Bell, Ali R. Ali, Drew Frase, Casey E. Hojecki, Gabriela A. Canziani, Irwin Chaiken, Toshitha Kannan, Estella Moffat, Carissa Embury-Hyatt, Sarah K. Wooton, Andrew Kossenkov, Ami Patel, Darwyn Kobasa, Michele A. Kutzler, Elias K. Haddad, David B. Weiner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite numerous clinically available vaccines and therapeutics, aged patients remain at increased risk for COVID-19 morbidity. Furthermore, various patient populations, including the aged can have suboptimal responses to SARS-CoV-2 vaccine antigens.
Externí odkaz:
https://doaj.org/article/54e6d5648e304ae68b9b6bf090ee114c
Autor:
Abdullah M Izmirly, Adam-Nicolas Pelletier, Jennifer Connors, Bhavani Taramangalam, Sawsan O Alturki, Emma A Gordon, Sana O Alturki, Joshua C Mell, Gokul Swaminathan, Vivin Karthik, Michele A Kutzler, Esper G Kallas, Rafick-Pierre Sekaly, Elias K Haddad
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
It has been estimated that more than 390 million people are infected with Dengue virus every year; around 96 millions of these infections result in clinical pathologies. To date, there is only one licensed viral vector-based Dengue virus vaccine CYD-
Externí odkaz:
https://doaj.org/article/b1414aecedfe466fae3efe9e5be08be1
Autor:
Sana O. Alturki, Sawsan O. Alturki, Jennifer Connors, Gina Cusimano, Michele A. Kutzler, Abdullah M. Izmirly, Elias K. Haddad
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome infecting animals and humans. Coronaviruses have been described more than 70 years ago and contain many species. Severe Acute Respiratory Syndrome (SARS) and Middle
Externí odkaz:
https://doaj.org/article/ff30ca378a5c48a983a06d25c46c39fe
Autor:
Jennifer Connors, Bhavani Taramangalam, Gina Cusimano, Matthew R. Bell, Stephanie M. Matt, Kaitlyn Runner, Peter J. Gaskill, Victor DeFilippis, Janko Nikolich-Žugich, Michele A. Kutzler, Elias K. Haddad
Publikováno v:
GeroScience. 44:2555-2572
The progressive impairment of immunity to pathogens and vaccines with aging is a significant public health problem as the world population shifts to an increased percentage of older adults (> 65). We have previously demonstrated that cells obtained f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5586db06fb55d968bf12858fed8bab1
https://doi.org/10.1007/s11357-022-00612-5
https://doi.org/10.1007/s11357-022-00612-5
Autor:
Ebony N. Gary, Michele A. Kutzler
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
A myriad of pathogens gain access to the host via the mucosal route; thus, vaccinations that protect against mucosal pathogens are critical. Pathogens such as HIV, HSV, and influenza enter the host at mucosal sites such as the intestinal, urogenital,
Externí odkaz:
https://doaj.org/article/b5d91cb449424a3187840208d3a97041
Autor:
Ebony N Gary, Michele A Kutzler
Publikováno v:
Clinical Medicine Insights: Pathology, Vol 10 (2017)
Human immunodeficiency virus 1 (HIV-1) is the causative agent of AIDS. There are currently more than 35 million people living with HIV infection worldwide, and more than 2 million new infections occur each year. The global pandemic caused by HIV-1 is
Externí odkaz:
https://doaj.org/article/f65eddc3b4ea4cb2ac3564d8401152e7
Autor:
Christopher Vinnard, Isabel Manley, Brittney Scott, Mariana Bernui, Joella Adams, Sheryl Varghese, Isaac Zentner, Michele A. Kutzler
Publikováno v:
Tuberculosis Research and Treatment, Vol 2017 (2017)
Background. Rifampin malabsorption is frequently observed in tuberculosis patients coinfected with human immunodeficiency virus (HIV) but cannot be predicted by patient factors such as CD4+ T cell count or HIV viral load. Methods. We sought to descri
Externí odkaz:
https://doaj.org/article/69a8158ccad64e999e370a2c56479ad6