Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michele A, Jaeger"'
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2604 (2008)
Alpha-dystrobrevin is a component of the dystrophin-glycoprotein complex (DGC) and is thought to have both structural and signaling roles in skeletal muscle. Mice deficient for alpha-dystrobrevin (adbn(-/-)) exhibit extensive myofiber degeneration an
Externí odkaz:
https://doaj.org/article/f44a2f19637d4a8fb17d315a17b8283d
Publikováno v:
The FASEB Journal. 23:2205-2214
We generated transgenic mice that overexpressed γ-cyto actin 2000-fold above wild-type levels in skeletal muscle. γ-cyto actin comprised 40% of total actin in transgenic skeletal muscle, with a concomitant 40% decrease in α-actin. Surprisingly, tr
Autor:
Jackie L McCourt, Katrina K Rhett, Dana M Talsness, Michele A. Jaeger, Joseph J. Belanto, James M. Ervasti
Publikováno v:
Skeletal Muscle
Background The X-linked recessive disease Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding the protein dystrophin. Despite its large size, dystrophin is a highly stable protein, demonstrating cooperative unfolding during
Autor:
Michael J. Ackerman, Michele A. Jaeger, Sara L. Van Driest, Melissa L. Will, Bernard J. Gersh, A. Jamil Tajik, Steve R. Ommen
Publikováno v:
Journal of the American College of Cardiology. 44:602-610
OBJECTIVES We sought to determine the prevalence and phenotype of beta-myosin heavy chain gene MYH7 mutations in a large cohort of unrelated patients with hypertrophic cardiomyopathy (HCM). BACKGROUND Hypertrophic cardiomyopathy is a heterogeneous ca
Publikováno v:
Veterinary pathology. 52(1)
There are few reports of naturally occurring muscular dystrophy in domestic animals. Herein, we describe a case of muscular dystrophy in a 4-year-old neutered male American domestic shorthair cat that died unexpectedly following anesthesia for an ele
Autor:
Dawn A. Lowe, Kristen A. Baltgalvis, Michele A. Jaeger, Daniel P. Fitzsimons, Stanley A. Thayer, James M. Ervasti
Publikováno v:
Skeletal Muscle
Skeletal Muscle, Vol 1, Iss 1, p 32 (2011)
Skeletal Muscle, Vol 1, Iss 1, p 32 (2011)
Background γ-cytoplasmic (γ-cyto) actin levels are elevated in dystrophin-deficient mdx mouse skeletal muscle. The purpose of this study was to determine whether further elevation of γ-cyto actin levels improve or exacerbate the dystrophic phenoty
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(7)
We generated transgenic mice that overexpressed γ-cyto actin 2000-fold above wild-type levels in skeletal muscle. γ-cyto actin comprised 40% of total actin in transgenic skeletal muscle, with a concomitant 40% decrease in α-actin. Surprisingly, tr
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2604 (2008)
PLoS ONE
PLoS ONE
Alpha-dystrobrevin is a component of the dystrophin-glycoprotein complex (DGC) and is thought to have both structural and signaling roles in skeletal muscle. Mice deficient for alpha-dystrobrevin (adbn(-/-)) exhibit extensive myofiber degeneration an
Publikováno v:
Ophthalmology. 94(5)
The zonules of 27 postmortem eyes were studied grossly using a histologic staining technique that allowed easy visualization of the zonules. Large disinsertions of the zonules were present in 5 of the 20 eyes that had undergone extracapsular cataract
Publikováno v:
Survey of ophthalmology. 31(6)
Although granular cell tumor (GCT) has been a distinct pathological entity since 1926, confusion and controversy have long existed regarding the nature and histogenesis of the tumor. Twenty-five cases of granular cell tumor involving the orbit and oc