Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michele J. Writer"'
Autor:
Panagiotis G. Kyrtatos, Stephen L. Hart, Michele J. Writer, Cameron W. McLeod, Gavin D. Kenny, John A. Pugh, Mark F. Lythgoe, Andrew S. Lowe, Edward White, Alison Bienemann, Steven S. Gill, Claudio Villegas-Llerena
Publikováno v:
Journal of Controlled Release
Gadolinium-labelled nanocomplexes offer prospects for the development of real-time, non-invasive imaging strategies to visualise the location of gene delivery by MRI. In this study, targeted nanoparticle formulations were prepared comprising a cation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3717cee3782a03fb921dd1e171ec6193
Autor:
Michele J. Writer, Jimmy D. Bell, Edward White, Cameron W. McLeod, Alan G. Cox, Josephine Bunch, John A. Pugh, Alison Bienemann, Stephen L. Hart
Publikováno v:
Analytical and Bioanalytical Chemistry. 403:1641-1649
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been used to map the spatial distribution of magnetic resonance imaging (MRI) contrast agents (Gd-based) in histological sections in order to explore synergies with in vivo M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bd705e76e12bcf188ecf5c6b8be55d
https://doi.org/10.1007/s00216-012-5973-z
https://doi.org/10.1007/s00216-012-5973-z
Autor:
Supti Sarkar, Stephen L. Hart, Michael A. Pilkington-Miksa, S. E. Barker, Helen C. Hailes, Michele J. Writer, Alethea B. Tabor, Parviz Ayazi Shamlou
Publikováno v:
European Journal of Organic Chemistry. 2008:2900-2914
Improving the buffer and serum stability of non-viral gene delivery vectors, and increasing their circulation time in vivo, is an important focus of current research in gene therapy. The most successful strategies to date have involved shielding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b2be646916ab03492185a1a1e8012ca
https://doi.org/10.1002/ejoc.200701188
https://doi.org/10.1002/ejoc.200701188
Autor:
Stephen L. Hart, Stephen E. Bottoms, Michele J. Writer, Christopher O'Callaghan, Martin Elbs, Aristides D. Tagalakis, Helen C. Hailes, John B. Wong, Adam Jaffe, Robin J. McAnulty, James Devaney, Alethea B. Tabor
Publikováno v:
Molecular Therapy. 16:907-915
Synthetic vectors for cystic fibrosis (CF) gene therapy are required that efficiently and safely transfect airway epithelial cells, rather than alveolar epithelial cells or macrophages, and that are nonimmunogenic, thus allowing for repeated delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0b6822cfa95b703d461cc3ade3fb7b
https://doi.org/10.1038/mt.2008.38
https://doi.org/10.1038/mt.2008.38
Autor:
Parviz Ayazi Shamlou, Stephen L. Hart, Michele J. Writer, Helen C. Hailes, Qing-Hai Meng, Supti Sarkar, Suzie E. Barker, Alethea B. Tabor, Michael A. Pilkington-Miksa
Publikováno v:
Bioconjugate Chemistry. 18:1800-1810
We have developed efficient synthetic routes to two hydrophobic amino acids, suitably protected for solid-phase peptide synthesis, and have successfully synthesized peptides containing these or other hydrophobic amino acids as spacers between a Lys16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b7e524a011b02c5156c510d293c1ea
https://doi.org/10.1021/bc0700943
https://doi.org/10.1021/bc0700943
Autor:
Helen C. Hailes, Alethea B. Tabor, John B. Wong, Stephen L. Hart, Parviz Ayazi Shamlou, Michele J. Writer, Christopher A. Hurley, M. Jayne Lawrence, Robin J. McAnulty, Danielle M. Copeman, Marianne Odlyha, Supti Sarkar
Publikováno v:
Journal of Liposome Research. 16:373-389
We have previously described a lipopolyplex formulation comprising a mixture of a cationic peptide with an integrin-targeting motif (K16GACRRETAWACG) and Lipofectin, a liposome consisting of DOTMA and DOPE in a 1:1 ratio. The high transfection effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5de88fd814f50c3556dec9e2fa6632
https://doi.org/10.1080/08982100600992500
https://doi.org/10.1080/08982100600992500
Autor:
M F Mohd Mustapa, Christopher A. Hurley, S. E. Barker, Stephen L. Hart, Supti Sarkar, John B. Wong, A. Nicol, Parviz Ayazi Shamlou, D. Zicha, B. Papahadjopoulos-Sternberg, P. C. Bell, Michele J. Writer, Michael A. Pilkington-Miksa, Erwann Guénin, Helen C. Hailes, Alethea B. Tabor
Publikováno v:
Biochemistry
Biochemistry, American Chemical Society, 2007, 46 (45), pp.12930-12944. ⟨10.1021/bi701014y⟩
Biochemistry, American Chemical Society, 2007, 46 (45), pp.12930-12944. ⟨10.1021/bi701014y⟩
1 - Article; Nonviral gene delivery vectors now show good therapeutic potential: however, detailed characterization of the composition and macromolecular organization of such particles remains a challenge. This paper describes experiments to elucidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adcdc9f0f6bd47b199c98c67b12e259
https://hal.archives-ouvertes.fr/hal-00463306
https://hal.archives-ouvertes.fr/hal-00463306
Autor:
Michael A. Pilkington-Miksa, Angelika Kritz, Stephen L. Hart, Alethea B. Tabor, Douglas H. Lester, Barry Marshall, Helen C. Hailes, S. E. Barker, Marianne C. Jacobsen, Nigel Klein, Paul C. Bell, Michele J. Writer
Publikováno v:
Journal of drug targeting. 12(4)
Human airway epithelial cell targeting peptides were identified by biopanning on 1HAEo-cells, a well characterised epithelial cell line. Bound phage were recovered after three rounds of binding, high stringency washing and elution, leading to the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a77553bbaa7595283d62538be17f17
https://pubmed.ncbi.nlm.nih.gov/15506167
https://pubmed.ncbi.nlm.nih.gov/15506167
Autor:
Alethea B. Tabor, Ron Scheule, Michele J. Writer, Helen C. Hailes, Stephen L. Hart, Aris Tagalakis, Adam Jaffe, Robin J. McAnulty, SE Bottoms, Seng H. Cheng, James Devaney, John B. Wong
Publikováno v:
Molecular Therapy. 13:S269-S270
We are developing synthetic,targeted vector systems for the respiratory system to treat diseases such as cystic fibrosis (CF). Lip/Tide-I vectors comprised an integrin-targeting peptide and DOTMA/DOPE which displayed transfected human epithelial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967407d8b32037ff6c77870611ce71f4
Autor:
John B. Wong, Stephen L. Hart, M. Jayne Lawrence, Michele J. Writer, Helen C. Hailes, Christopher A. Hurley, Scott Alexander Irvine, Jimmy Ho, Alethea B. Tabor
Publikováno v:
Organic & Biomolecular Chemistry. 6:2554
A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolypl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1b9faa81a811dc5a948463d1afa9fc
https://doi.org/10.1039/b719702k
https://doi.org/10.1039/b719702k