Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michele, Madonna"'
Autor:
Francesco Di Meo, Stefania Filosa, Michele Madonna, Gerarda Giello, Alba Di Pardo, Vittorio Maglione, Alfonso Baldi, Stefania Crispi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-11 (2019)
Abstract Background A major limitation in the treatment for malignant mesothelioma is related to serious side effects caused by chemotherapeutics and to the development of cancer-resistance. Advances in cancer therapies have been reached thanks to th
Externí odkaz:
https://doaj.org/article/beb69be76020412e8c356970f43f5baa
Autor:
Francesca Biagioni, Anderson Gaglione, Filippo S. Giorgi, Domenico Bucci, Slavianka Moyanova, Antonio De Fusco, Michele Madonna, Francesco Fornai
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 76-94 (2019)
Status epilepticus (SE) of limbic onset might cause degenerative phenomena in different brain structures, and may be associated with chronic cognitive and EEG effects. In the present study SE was evoked focally by microinfusing picomolar doses of cyc
Externí odkaz:
https://doaj.org/article/fd8f09c80ee24a80b4765750cdddfb1f
Autor:
Federica Mastroiacovo, Slavianka Moyanova, Milena Cannella, Anderson Gaglione, Remy Verhaeghe, Giovanna Bozza, Michele Madonna, Marta Motolese, Anna Traficante, Barbara Riozzi, Valeria Bruno, Giuseppe Battaglia, David Lodge, Ferdinando Nicoletti
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient global ischemia, whereas receptor activation amplifies neuronal death. Th
Externí odkaz:
https://doaj.org/article/5550e85d75bd4ac5a3042846c1d630dd
Autor:
Alba Di Pardo, Enrico Amico, Abdul Basit, Andrea Armirotti, Piyush Joshi, M. Diana Neely, Romina Vuono, Salvatore Castaldo, Anna F. Digilio, Francesco Scalabrì, Giuseppe Pepe, Francesca Elifani, Michele Madonna, Se Kyoo Jeong, Bu-Mahn Park, Maurizio D’Esposito, Aaron B. Bowman, Roger A. Barker, Vittorio Maglione
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Huntington’s disease is characterized by a complex and heterogeneous pathogenic profile. Studies have shown that disturbance in lipid homeostasis may represent a critical determinant in the progression of several neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/bf0f9516edd7471585e05c6cc1d03c10
Autor:
Alba Di Pardo, Giuseppe Pepe, Salvatore Castaldo, Federico Marracino, Luca Capocci, Enrico Amico, Michele Madonna, Susy Giova, Se Kyoo Jeong, Bu-Mahn Park, Byeong Deog Park, Vittorio Maglione
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Although several agents have been identified to provide therapeutic benefits in Huntington disease (HD), the number of conventionally used treatments remains limited and only symptomatic. Thus, it is plausible that the need to identify new therapeuti
Externí odkaz:
https://doaj.org/article/910e1a0379c0463d96e94853e7357092
Autor:
Gabriele Giacomo Schiattarella, Albino Carrizzo, Federica Ilardi, Antonio Damato, Mariateresa Ambrosio, Michele Madonna, Valentina Trimarco, Marina Marino, Elena De Angelis, Silvio Settembrini, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito, Carmine Vecchione
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 8 (2018)
BackgroundVascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho‐related GTPase protein, Rac1, can influence both endothelial and platelet function and might re
Externí odkaz:
https://doaj.org/article/89ef7fc4fd244d2eb5aafc7102ee100d
Autor:
Domenico Bucci, Carla L. Busceti, Maria T. Calierno, Paola Di Pietro, Michele Madonna, Francesca Biagioni, Larisa Ryskalin, Fiona Limanaqi, Ferdinando Nicoletti, Francesco Fornai
Publikováno v:
Frontiers in Neuroanatomy, Vol 11 (2017)
Catecholamine nuclei within the brainstem reticular formation (RF) play a pivotal role in a variety of brain functions. However, a systematic characterization of these nuclei in the very same experimental conditions is missing so far. Tyrosine hydrox
Externí odkaz:
https://doaj.org/article/7e893201e01a42c3bb6abae5a784634e
Autor:
Carmine Vecchione, Francesco Fazio, Albino Carrizzo, Luana Lionetto, Antonio Damato, Luca Capocci, Mariateresa Ambrosio, Giuseppe Battaglia, Valeria Bruno, Michele Madonna, Maurizio Simmaco, Ferdinando Nicoletti
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The kynurenine pathway of tryptophan metabolism is activated by pro-inflammatory cytokines. L-kynurenine, an upstream metabolite of the pathway, acts as a putative endothelium-derived relaxing factor, and has been hypothesized to play a causative rol
Externí odkaz:
https://doaj.org/article/233a9b22b87b478ea3e3f9da597f2ea2
Autor:
Claudio De Felice, Floriana Della Ragione, Cinzia Signorini, Silvia Leoncini, Alessandra Pecorelli, Lucia Ciccoli, Francesco Scalabrì, Federico Marracino, Michele Madonna, Giuseppe Belmonte, Laura Ricceri, Bianca De Filippis, Giovanni Laviola, Giuseppe Valacchi, Thierry Durand, Jean-Marie Galano, Camille Oger, Alexandre Guy, Valérie Bultel-Poncé, Jacky Guy, Stefania Filosa, Joussef Hayek, Maurizio D'Esposito
Publikováno v:
Neurobiology of Disease, Vol 68, Iss , Pp 66-77 (2014)
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of the cases by loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). High circulating
Externí odkaz:
https://doaj.org/article/f05bc40df8d64a928adb14bd5f3ac97e
Autor:
Arianna Brancaccio, Maria R. Matarazzo, Salvatore Fioriniello, Federico Marracino, Alessia Romano, Domenico Marano, Carmela Zarrillo, Michele Madonna, Maurizio D'Esposito, Eva Csukonyi, Floriana Della Ragione
Publikováno v:
Stem Cell Reports
Summary Methyl-CpG binding protein 2 (MeCP2) has historically been linked to heterochromatin organization, and in mouse cells it accumulates at pericentric heterochromatin (PCH), closely following major satellite (MajSat) DNA distribution. However, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547edab55c9bc1ea8826c8d07977c2ee
https://doi.org/10.1016/j.stemcr.2020.11.006
https://doi.org/10.1016/j.stemcr.2020.11.006