Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Michele, De Luca"'
Autor:
Maria Pia Polito, Grazia Marini, Alessandra Fabrizi, Laura Sercia, Elena Enzo, Michele De Luca
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-10 (2024)
Abstract Epidermal stem cells orchestrate epidermal renewal and timely wound repair through a tight regulation of self-renewal, proliferation, and differentiation. In culture, human epidermal stem cells generate a clonal type referred to as holoclone
Externí odkaz:
https://doaj.org/article/c421b30b8308404a98973d249cce780e
Autor:
Laura Sercia, Oriana Romano, Grazia Marini, Elena Enzo, Mattia Forcato, Laura De Rosa, Michele De Luca
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101311- (2024)
Lamellar ichthyosis (LI) is a chronic disease, mostly caused by mutations in the TGM1 gene, marked by impaired skin barrier formation. No definitive therapies are available, and current treatments aim at symptomatic relief. LI mouse models often fail
Externí odkaz:
https://doaj.org/article/5964d676582b409c971425f07d256aa7
Autor:
Anna Ramunno, Rosa Maria Vitale, Pietro Amodeo, Carlo Crescenzi, Alice Panti, Paolo Fiorenzani, Michele De Luca, Umile Gianfranco Spizzirri, Donatella Restuccia, Francesca Aiello, Fabio Fusi
Publikováno v:
Molecules, Vol 29, Iss 23, p 5693 (2024)
The huge amount of citrus peel produced worldwide represents an economic burden for society. However, this agricultural by-product is a rich source of natural molecules, potentially endowed with interesting pharmacological activities. In this regard,
Externí odkaz:
https://doaj.org/article/86249a6523ba40caa3108bb605c7eee1
Autor:
Ensieh Poursani, Giuseppe Cirillo, Manuela Curcio, Orazio Vittorio, Michele De Luca, Antonella Leggio, Fiore Pasquale Nicoletta, Francesca Iemma
Publikováno v:
International Journal of Pharmaceutics: X, Vol 7, Iss , Pp 100235- (2024)
In this study, we developed self-assembling nanoparticles (LCPs) able to trigger the release of Chlorambucil (Chl) and Doxorubicin (DOX) to MDA-MB-231 cells by exploiting the enzyme and redox signals. The DOX loaded LCPs was prepared by the self-asse
Externí odkaz:
https://doaj.org/article/cb289e5ace8b4da3acbb7b9211893337
Autor:
Mariangela Marrelli, Michele De Luca, Claudia-Crina Toma, Fedora Grande, Maria Antonietta Occhiuzzi, Rosalba Caruso, Filomena Conforti, Giancarlo Statti
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31080- (2024)
The synergistic effects of essential oils (EOs) from three aromatic plant species, Foeniculum vulgare subsp. piperitum (C.Presl) Bég. (FV), Origanum heracleoticum L. (OH) and Lavandula austroapennina N.G.Passal., Tundis & Upson. (LA), were evaluated
Externí odkaz:
https://doaj.org/article/b3cdc330addf41cc9589eef1c5d3be4e
Autor:
Michele De Luca, Maria Antonietta Occhiuzzi, Bruno Rizzuti, Giuseppina Ioele, Gaetano Ragno, Antonio Garofalo, Fedora Grande
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1600-1609 (2022)
Letrozole is one of the most prescribed drugs for the treatment of breast cancer in post-menopausal women, and it is endowed with selective peripheral aromatase inhibitory activity. The efficacy of this drug is also a consequence of its long-lasting
Externí odkaz:
https://doaj.org/article/63a9b80e702a4829a800e614720c6723
Autor:
Martina Chieffallo, Michele De Luca, Fedora Grande, Maria Antonietta Occhiuzzi, Miyase Gözde Gündüz, Antonio Garofalo, Giuseppina Ioele
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 206 (2024)
1,4-dihydropyridines (1,4-DHPs) are widely recognized as highly effective L-type calcium channel blockers with significant therapeutic benefits in the treatment of cardiovascular disorders. 1,4-DHPs can also target T-type calcium channels, making the
Externí odkaz:
https://doaj.org/article/118e6946001645338054141639f4229d
Autor:
Giuseppe Cirillo, Manuela Curcio, Cesare Oliviero Rossi, Giovanni De Filpo, Mariafrancesca Baratta, Michele De Luca, Francesca Iemma, Fiore Pasquale Nicoletta
Publikováno v:
Molecules, Vol 28, Iss 15, p 5893 (2023)
The conjugation of polyphenols is a valuable strategy with which to confer tailored properties to polymeric materials of biomedical interest. Within this investigation, we aim to explore the possibility to use this synthetic approach to increase the
Externí odkaz:
https://doaj.org/article/e403a0727e02456fa97767804529e4db
Autor:
Jessica Ceramella, Chiara La Torre, Michele De Luca, Domenico Iacopetta, Alessia Fazio, Alessia Catalano, Gaetano Ragno, Pasquale Longo, Maria Stefania Sinicropi, Camillo Rosano
Publikováno v:
PeerJ, Vol 10, p e13683 (2022)
Background Pulse crops are considered the major sources of proteins, dietary fiber, micronutrients, and bioactive phytochemicals. Among the numerous pulse crops, broad beans (Vicia faba L.) have received particular attention due to their nutraceutica
Externí odkaz:
https://doaj.org/article/6267050658b64ca59f20ef696e1762dd
Autor:
Elena Enzo, Alessia Secone Seconetti, Mattia Forcato, Elena Tenedini, Maria Pia Polito, Irene Sala, Sonia Carulli, Roberta Contin, Clelia Peano, Enrico Tagliafico, Silvio Bicciato, Sergio Bondanza, Michele De Luca
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Epidermal cultures can treat skin diseases, such as Junctional Epidermolysis Bullosa, but the signature of stem cells is unclear. By single cell RNAseq analyses on human keratinocytes, the authors identify the molecular profile of holoclones and the
Externí odkaz:
https://doaj.org/article/24ade267e8ad41b39a4b9790df32c377