Aptamer-Based Proteomics Measuring Preoperative Cerebrospinal Fluid Protein Alterations Associated with Postoperative Delirium

Autor: Simon T. Dillon, Sarinnapha M. Vasunilashorn, Hasan H. Otu, Long Ngo, Tamara Fong, Xuesong Gu, Michele Cavallari, Alexandra Touroutoglou, Mouhsin Shafi, Sharon K. Inouye, Zhongcong Xie, Edward R. Marcantonio, Towia A. Libermann

Publikováno v: Biomolecules, Vol 13, Iss 9, p 1395 (2023)

Delirium is a common postoperative complication among older patients with many adverse outcomes. Due to a lack of validated biomarkers, prediction and monitoring of delirium by biological testing is not currently feasible. Circulating proteins in cer

Externí odkaz: https://doaj.org/article/bb2419d550e8401db3bd11a1ec37db0e

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

Autor: Tammy T. Hshieh, Sarinnapha M. Vasunilashorn, Madeline L. D'Aquila, Steven E. Arnold, Bradford C. Dickerson, Tamara G. Fong, Richard N. Jones, Edward R. Marcantonio, Eva M. Schmitt, Guoquan Xu, Yun Gou, Fan Chen, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha R. Abdeen, Jeffrey K. Lange, Brandon E. Earp, Alexandra Touroutoglou, Becky C. Carlyle, Pia Kivisakk‐Webb, Thomas G. Travison, Simon T. Dillon, Towia A. Libermann, Sharon K. Inouye, RISE Study Group, Steven Arnold, Bradford Dickerson, Tamara Fong, Richard Jones, Thomas Travison, Michele Cavallari, Jacob Hooker, Tammy Hshieh, Savannah Kandigian, Long Ngo, Hasan Otu, Bianca Trombetta, Sarinnapha Vasunilashorn, Ayesha Abdeen, Douglas Ayres, Brandon Earp, Jeffrey Lange, Gregory Brick, Antonia Chen, Robert Davis, Jacob Drew, Richard Iorio, Fulton Kornack, Michael Weaver, Anthony Webber, Richard Wilk, Lisa Kunze, David Shaff, Kamen Vlassakov, Brett Armstrong, Angelee Banda, Sylvie Bertrand, Madeline D'Aquila, Jacqueline Gallagher, Baileigh Hightower, Shannon Malloy, Jacqueline Nee, Chloe Nobuhara, Abigail Overstreet, Annie Racine, David Urick, Grae Arabasz, Michael Brickhouse, Regan Butterfield, Shirley Hsu, Sara Makaretz, Judit Sore, Douglas Tommet, Sabrina Carretie, Ted Gruen, Katherine Tasker

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 752-762 (2019)

Abstract Introduction The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]‐PBR28 positron‐emission tomography imaging. Methods This study invo

Externí odkaz: https://doaj.org/article/b778d4458ac14bf5af9509298ab701af

Corrigendum: Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System

Autor: Fernanda Troili, Virginia Cipollini, Marco Moci, Emanuele Morena, Miklos Palotai, Virginia Rinaldi, Carmela Romano, Giovanni Ristori, Franco Giubilei, Marco Salvetti, Francesco Orzi, Charles R. G. Guttmann, Michele Cavallari

Publikováno v: Frontiers in Neuroanatomy, Vol 14 (2020)

Externí odkaz: https://doaj.org/article/abf9a452c8034932b13504222b5485bb

The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium

Autor: Yuta Katsumi, Annie M. Racine, Angel Torrado-Carvajal, Marco L. Loggia, Jacob M. Hooker, Douglas N. Greve, Baileigh G. Hightower, Ciprian Catana, Michele Cavallari, Steven E. Arnold, Tamara G. Fong, Sarinnapha M. Vasunilashorn, Edward R. Marcantonio, Eva M. Schmitt, Guoquan Xu, Towia A. Libermann, Lisa Feldman Barrett, Sharon K. Inouye, Bradford C. Dickerson, Alexandra Touroutoglou, Jessica A. Collins

Publikováno v: NeuroImage: Clinical, Vol 27, Iss , Pp 102346- (2020)

Major surgery is associated with a systemic inflammatory cascade that is thought, in some cases, to contribute to transient and/or sustained cognitive decline, possibly through neuroinflammatory mechanisms. However, the relationship between surgery,

Externí odkaz: https://doaj.org/article/d87787ce688d44929980f053d2589981

Longitudinal microstructural changes of cerebral white matter and their association with mobility performance in older persons.

Autor: Nicola Moscufo, Dorothy B Wakefield, Dominik S Meier, Michele Cavallari, Charles R G Guttmann, William B White, Leslie Wolfson

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194051 (2018)

Mobility impairment in older persons is associated with brain white matter hyperintensities (WMH), a common finding in magnetic resonance images and one established imaging biomarker of small vessel disease. The contribution of possible microstructur

Externí odkaz: https://doaj.org/article/043195dca9bf4a628360e15e0774bd70