Výsledky vyhledávání - "Michelangelo Marasco"

Akademický článek

Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet

Autor: Michelangelo Marasco, John Kirkpatrick, Teresa Carlomagno, Jochen S. Hub, Massimiliano Anselmi

Publikováno v: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1169-1180 (2024)

SHP2 is a tyrosine phosphatase that plays a regulatory role in multiple intracellular signaling cascades and is known to be oncogenic in certain contexts. In the absence of effectors, SHP2 adopts an autoinhibited conformation with its N-SH2 domain bl

Externí odkaz: https://doaj.org/article/0029acf72ec94573abd1f3e2e607cb5f

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Akademický článek

Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network

Autor: Michelangelo Marasco, John Kirkpatrick, Vittoria Nanna, Justyna Sikorska, Teresa Carlomagno

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2398-2415 (2021)

SHP2 is a ubiquitous protein tyrosine phosphatase, whose activity is regulated by phosphotyrosine (pY)-containing peptides generated in response to extracellular stimuli. Its crystal structure reveals a closed, auto-inhibited conformation in which th

Externí odkaz: https://doaj.org/article/ec15cb08fa044f438eafe0c8843478dd

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Akademický článek

Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.

Autor: Naira Samarina, George Ssebyatika, Tanvi Tikla, Ja-Yun Waldmann, Bizunesh Abere, Vittoria Nanna, Michelangelo Marasco, Teresa Carlomagno, Thomas Krey, Thomas F Schulz

Publikováno v: PLoS Pathogens, Vol 17, Iss 6, p e1009635 (2021)

Kaposi Sarcoma-associated herpesvirus (KSHV) causes three human malignancies, Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL) and the plasma cell variant of multicentric Castleman's Disease (MCD), as well as an inflammatory cytokine syndrome (KI

Externí odkaz: https://doaj.org/article/5bd22e854467486fb7a9d993ffd4e8b5

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Akademický článek

Specificity and regulation of phosphotyrosine signaling through SH2 domains

Autor: Michelangelo Marasco, Teresa Carlomagno

Publikováno v: Journal of Structural Biology: X, Vol 4, Iss , Pp 100026- (2020)

Phosphotyrosine (pY) signaling is instrumental to numerous cellular processes. pY recognition occurs through specialized protein modules, among which the Src-homology 2 (SH2) domain is the most common. SH2 domains are small protein modules with an in

Externí odkaz: https://doaj.org/article/2568e10506734a449f11d19e225e5a71

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