Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michela Spinelli"'
Autor:
Renata Tisi, Michela Spinelli, Alessandro Palmioli, Cristina Airoldi, Paolo Cazzaniga, Daniela Besozzi, Marco S. Nobile, Elisa Mazzoleni, Simone Arnhold, Luca De Gioia, Rita Grandori, Francesco Peri, Marco Vanoni, Elena Sacco
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Ras oncoproteins play a crucial role in the onset, maintenance, and progression of the most common and deadly human cancers. Despite extensive research efforts, only a few mutant-specific Ras inhibitors have been reported. We show that cmp4–previou
Externí odkaz:
https://doaj.org/article/12b03615f25342f69a2d6b9a39948924
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163790 (2016)
Cancer cells have an increased demand for amino acids and require transport even of non-essential amino acids to support their increased proliferation rate. Besides their major role as protein synthesis precursors, the two proteinogenic sulfur-contai
Externí odkaz:
https://doaj.org/article/d3374af1e589459a8952291c83db4bc1
Autor:
Carmen Fava, Monica Bocchia, Valentina Gaidano, Bruno Martino, Mohammad Houshmand, Gianni Binotto, Sabina Russo, Fabio Stagno, Patrizia Pregno, Mario Annunziata, Paola Circosta, Silvio Aime, Mahin Nikougoftar Zarif, Ester Pungolino, Rachele Stefania, Francesca Garello, Alessandra Iurlo, Massimiliano Bonifacio, Luigia Luciano, Giorgina Specchia, Alessandro Cignetti, Sara Galimberti, Michela Spinelli, Giuseppe Saglio
Publikováno v:
Cancers
Volume 13
Issue 6
Cancers, Vol 13, Iss 1311, p 1311 (2021)
Volume 13
Issue 6
Cancers, Vol 13, Iss 1311, p 1311 (2021)
Simple Summary Chronic myeloid leukemia stem cells (CML LSCs) are a rare and quiescent population that are resistant to tyrosine kinase inhibitors. CML LSCs have many features in common with hematopoietic stem cells (HSCs) and selectively targeting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96f280aa511d19fc2c8378d41f3fdc2
http://hdl.handle.net/2318/1786568
http://hdl.handle.net/2318/1786568
Autor:
Cristina Airoldi, Gaia De Sanctis, Alessandro Palmioli, Carlotta Ciaramelli, Renata Tisi, Elena Sacco, Michela Spinelli
Publikováno v:
Chemistry - An Asian Journal. 12:2457-2466
Recent epidemiological studies have demonstrated that the consumption of healthy foods that are particularly rich in polyphenols might reduce the incidence of cancer and neurodegenerative diseases. In particular, chlorogenic acids (CGAs) occur ubiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d99fa94b3001d306d8417c7b660871
https://doi.org/10.1002/asia.201700844
https://doi.org/10.1002/asia.201700844
Publikováno v:
Expert Opinion on Therapeutic Patents. 22:1263-1287
Introduction: Ras proteins are small GTPases molecular switches that cycle through two alternative conformational states, a GDP-bound inactive state and a GTP-bound active state. In the active state, Ras proteins interact with and modulate the activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e9fcf143080de7ab482882ddba624e
https://doi.org/10.1517/13543776.2012.728586
https://doi.org/10.1517/13543776.2012.728586
Autor:
Cristina Airoldi, Maria Elena Regonesi, Marcella Bonanomi, Cristina Visentin, Antonino Natalello, Paolo Tortora, Marco Vanoni, Michela Spinelli
Epigallocatechin-3-gallate (EGCG) and tetracycline are two known inhibitors of amyloid aggregation able to counteract the fibrillation of most of the proteins involved in neurodegenerative diseases. We have recently investigated their effect on ataxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84aff46c016b81772ce63b3b72f0d059
http://hdl.handle.net/10281/93642
http://hdl.handle.net/10281/93642
Autor:
Andrea Morrione, Lilia Alberghina, Rita Grandori, David Metalli, Elena Sacco, Marco Vanoni, Romilde Manzoni, Michela Spinelli, Silvio Traversa, Maria Šamalikova
Publikováno v:
Biotechnology advances. 30(1)
Mutations of RAS genes are critical events in the pathogenesis of different human tumors and Ras proteins represent a major clinical target for the development of specific inhibitors to use as anticancer agents. Here we present RasGRF1-derived peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce82420a77594c596de71d90e528f47
https://pubmed.ncbi.nlm.nih.gov/21620943
https://pubmed.ncbi.nlm.nih.gov/21620943
Autor:
Andrea Morrione, Francesca Lovat, Marco Genua, Michela Spinelli, Renato V. Iozzo, Lilia Alberghina, Marco Vanoni, Leonard G. Gomella, Shi Qiong Xu, Farida Tripodi, Raffaele Baffa, David Metalli
The insulin-like growth factor receptor I (IGF-IR) plays an essential role in transformation by promoting cell growth and protecting cancer cells from apoptosis. Aberrant IGF-IR signaling is implicated in several types of tumors, including carcinomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bf378f62458a55ff996ec2e33ebbf1
https://europepmc.org/articles/PMC2877859/
https://europepmc.org/articles/PMC2877859/
Publikováno v:
Journal of Biotechnology. 150:92-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d276d759ea4e28ab69fb62a7e8db56
https://doi.org/10.1016/j.jbiotec.2010.08.238
https://doi.org/10.1016/j.jbiotec.2010.08.238