Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michela Simbula"'
Autor:
Michela Simbula, Maria Francesca Manchinu, Maura Mingoia, Mauro Pala, Isadora Asunis, Cristian Antonio Caria, Lucia Perseu, Manan Shah, Merlin Crossley, Paolo Moi, Maria Serafina Ristaldi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102025- (2023)
Hemoglobin switching is a complex biological process not yet fully elucidated. The mechanism regulating the suppression of fetal hemoglobin (HbF) expression is of particular interest because of the positive impact of HbF on the course of diseases suc
Externí odkaz:
https://doaj.org/article/51a79e8cc1744969890ec07116199680
Autor:
Maria Francesca Manchinu, Michela Simbula, Cristian Antonio Caria, Ester Musu, Lucia Perseu, Susanna Porcu, Maristella Steri, Daniela Poddie, Jessica Frau, Eleonora Cocco, Laura Manunza, Susanna Barella, Maria Serafina Ristaldi
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Beta hemoglobinopathies are widely spread monogenic lethal diseases. Delta-globin gene activation has been proposed as a possible approach for curing these pathologies. The therapeutic potential of delta-globin, the non-alpha component of Hemoglobin
Externí odkaz:
https://doaj.org/article/479296ddec6e4e198f5c7a062e4db411
Autor:
Maria F. Manchinu, Maria F. Marongiu, Daniela Poddie, Carla Casu, Veronica Latini, Michela Simbula, Renzo Galanello, Paolo Moi, Antonio Cao, Susanna Porcu, Maria S. Ristaldi
Publikováno v:
Haematologica, Vol 99, Iss 1 (2014)
β-thalassemia and sickle cell disease are widespread fatal genetic diseases. None of the existing clinical treatments provides a solution for all patients. Two main strategies for treatment are currently being investigated: (i) gene transfer of a no
Externí odkaz:
https://doaj.org/article/37993b6140f64f22918b4339e0a47ccd
Autor:
Cristian Antonio Caria, Daniela Poddie, Marta Anna Kowalik, Michela Simbula, Susanna Barella, Andrea Perra, Lucia Perseu, Maria F. Marongiu, Roberto Littera, Susanna Porcu, Franca Rosa Demartis, Maria Serafina Ristaldi
Publikováno v:
British Journal of Haematology. 193:1228-1237
Sickle cell disease (SCD) is a widespread genetic disease associated with severe disability and multi-organ damage, resulting in a reduced life expectancy. None of the existing clinical treatments provide a solution for all patients. Gene therapy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725405bc573b6042c46ebeb1f4ad55d0
https://doi.org/10.1111/bjh.17561
https://doi.org/10.1111/bjh.17561
Autor:
Susanna Porcu, Daniela Poddie, Susanna Barella, Maria Francesca Manchinu, Laura Manunza, Michela Simbula, Cristian Antonio Caria, Lucia Perseu, Eleonora Cocco, Jessica Frau, Maristella Steri, Ester Musu, Maria Serafina Ristaldi
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, Vol 7 (2020)
Frontiers in Medicine, Vol 7 (2020)
Beta hemoglobinopathies are widely spread monogenic lethal diseases. Delta-globin gene activation has been proposed as a possible approach for curing these pathologies. The therapeutic potential of delta-globin, the non-alpha component of Hemoglobin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1fe74db5fdde8e93aa34e689040bb2
http://europepmc.org/articles/PMC7256663
http://europepmc.org/articles/PMC7256663
Autor:
Cristian Antonio Caria, Susanna Porcu, Isadora Asunis, Ester Musu, Lucia Perseu, Maria Serafina Ristaldi, Carla Brancia, Maria Francesca Manchinu, Michela Simbula
Publikováno v:
Cell death and differentiation. 25(3)
A key regulatory gene in definitive erythropoiesis is the transcription factor Kruppel-like factor 1 (Klf1). Klf1 null mice die in utero by day 15.5 (E15.5) due to impaired definitive erythropoiesis and severe anemia. Definitive erythropoiesis takes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96a45f08a722c18fed9a443215d70ca
https://pubmed.ncbi.nlm.nih.gov/29230002
https://pubmed.ncbi.nlm.nih.gov/29230002
Autor:
Marta Anna Kowalik, Monica Pibiri, Andrea Perra, Giovanna M. Ledda-Columbano, Michela Simbula, Amedeo Columbano, Gabriella Simbula, Maria Teresa Cocco, Pia Sulas
Publikováno v:
The FASEB Journal. 22:2981-2989
Nonalcoholic fatty liver disease is the most common noninfectious liver disease in clinical practice, and there is an increasing need for new therapeutic approaches for the treatment of this liver disease. Here, we examined the effect of the thyroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4521615fcb18a04e3a59bfd697529d7a
https://doi.org/10.1096/fj.08-108464
https://doi.org/10.1096/fj.08-108464
Autor:
Antonio Cao, Maria Serafina Ristaldi, Maria Francesca Manchinu, Maria F. Marongiu, Paolo Moi, Michela Simbula, Daniela Poddie, Veronica Latini, Renzo Galanello, Susanna Porcu, Carla Casu
Publikováno v:
Haematologica. 99(1)
β-thalassemia and sickle cell disease are widespread fatal genetic diseases. None of the existing clinical treatments provides a solution for all patients. Two main strategies for treatment are currently being investigated: (i) gene transfer of a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0481374b407e9b19692ef42b2a9f14fe
https://pubmed.ncbi.nlm.nih.gov/23872310
https://pubmed.ncbi.nlm.nih.gov/23872310
Autor:
Amedeo Columbano, A Perra, Alessandro Uccheddu, Joseph Locker, Giovanna M. Ledda-Columbano, Michela Simbula, Monica Pibiri, Adolfo Pisanu, M. Deidda
Publikováno v:
Cell proliferation. 41(3)
Objectives: Liver regeneration is attenuated in old age and is substantially slower after 90% than after 70% partial hepatectomy (PH). We have previously demonstrated that the proliferative response to a primary mitogen is intact in aged mice, indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe0bbfd24e901d19ebcdb5ff5fd249d
https://pubmed.ncbi.nlm.nih.gov/18422700
https://pubmed.ncbi.nlm.nih.gov/18422700