HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel

Autor: Michela Sgubin, Silvia Pegoraro, Ilenia Pellarin, Gloria Ros, Riccardo Sgarra, Silvano Piazza, Gustavo Baldassarre, Barbara Belletti, Guidalberto Manfioletti

Publikováno v: Cell Death and Disease, Vol 13, Iss 5, Pp 1-13 (2022)

Abstract High Mobility Group A1 (HMGA1) is an architectural chromatin factor involved in the regulation of gene expression and a master regulator in Triple Negative Breast Cancer (TNBC). In TNBC, HMGA1 is overexpressed and coordinates a gene network

Externí odkaz: https://doaj.org/article/f453308a875b41cdaeec4b3be149f563

High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network

Autor: Rossella Zanin, Riccardo Sgarra, Gloria Ros, Daniela D'Angelo, Michela Sgubin, Sabrina Battista, Guidalberto Manfioletti, Silvia Pegoraro, Sara Petrosino

Publikováno v: International Journal of Molecular Sciences
International journal of molecular sciences
21 (2020). doi:10.3390/ijms21030717
info:cnr-pdr/source/autori:Sgarra, Riccardo; Pegoraro, Silvia; D'angelo, Daniela; Ros, Gloria; Zanin, Rossella; Sgubin, Michela; Petrosino, Sara; Battista, Sabrina; Manfioletti, Guidalberto/titolo:High mobility group a (HMGA): Chromatin nodes controlled by a knotty miRNA network/doi:10.3390%2Fijms21030717/rivista:International journal of molecular sciences (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:21
International Journal of Molecular Sciences, Vol 21, Iss 3, p 717 (2020)

High mobility group A (HMGA) proteins are oncofoetal chromatin architectural factors that are widely involved in regulating gene expression. These proteins are unique, because they are highly expressed in embryonic and cancer cells, where they play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0ea9bfcc6cfdf87a01ff2bcc327d42
http://europepmc.org/articles/PMC7038092