Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michela Perani"'
Autor:
Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these form
Externí odkaz:
https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
Autor:
Michela Perani, Peter J. Parker
Publikováno v:
Handbook of Biomarkers and Precision Medicine ISBN: 9780429202872
Handbook of Biomarkers and Precision Medicine
Handbook of Biomarkers and Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88990a276ef43c03f3cacd946af3e9ec
https://doi.org/10.1201/9780429202872-41
https://doi.org/10.1201/9780429202872-41
Publikováno v:
Annals of the New York Academy of Sciences. 1346:1-6
Beyond penetrant germline and somatic mutations, there are substantial challenges in extrapolating phenotypes from linear DNA sequences and transcriptomics. This brings a molecular pathology emphasis to the properties of the main players responsible
Autor:
Michael Hirsch, Venkatesh Mysore, Anton Arkhipov, Eric T. Kim, Dimitrios Korovesis, Michela Perani, Valeria Losasso, Alireza Lajevardipour, Daniel J. Rolfe, Linda J. Pike, Marisa L. Martin-Fernandez, Peter J. Parker, Andrew H. A. Clayton, Laura C. Zanetti-Domingues, Christopher J. Tynan, David E. Shaw, Sarah R. Needham, Selene K. Roberts, Martyn Winn, Yibing Shan, David T. Clarke
Publikováno v:
Nature Communications
Needham, S R, Roberts, S K, Arkhipov, A, Mysore, V P, Tynan, C J, Zanetti-Domingues, L C, Kim, E T, Losasso, V, Korovesis, D, Hirsch, M, Rolfe, D J, Clarke, D T, Winn, M D, Lajevardipour, A, Clayton, A H A, Pike, L J, Perani, M, Parker, P J, Shan, Y, Shaw, D E & Martin-Fernandez, M L 2016, ' EGFR oligomerization organizes kinase-active dimers into competent signalling platforms ', Nature Communications, vol. 7, 13307 . https://doi.org/10.1038/ncomms13307
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Needham, S R, Roberts, S K, Arkhipov, A, Mysore, V P, Tynan, C J, Zanetti-Domingues, L C, Kim, E T, Losasso, V, Korovesis, D, Hirsch, M, Rolfe, D J, Clarke, D T, Winn, M D, Lajevardipour, A, Clayton, A H A, Pike, L J, Perani, M, Parker, P J, Shan, Y, Shaw, D E & Martin-Fernandez, M L 2016, ' EGFR oligomerization organizes kinase-active dimers into competent signalling platforms ', Nature Communications, vol. 7, 13307 . https://doi.org/10.1038/ncomms13307
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures and functions of the oligomers are poorly understood. Here, we use
Autor:
Michelle D. Garrett, Catherine J.E. Ingram, Graham H. Goodwin, Per Antonson, Michela Perani, Rifat Hamoudi, Colin Cooper
Publikováno v:
Journal of Biological Chemistry. 280:42863-42876
The proto-oncoprotein SYT is involved in the unique translocation t(X;18) found in synovial sarcoma SYT-SSX fusions. SYT has a conserved N-terminal domain (SNH domain) that interacts with the human paralog of Drosophila Brahma (hBRM) and Brahma-relat
Publikováno v:
Oncogene. 22:8156-8167
Many studies have now established that the SWI/SNF chromatin remodelling complexes are involved in activation and repression of a variety of genes. In mammalian cells, these complexes contain the BRM and BRG1 helicase-like proteins that are thought t
Autor:
Leo M. Carlin, Rachel Evans, Franca Fraternali, Daniel R. Matthews, James A. Levitt, Tony Ng, N. Shaun B. Thomas, James Monypenny, Simon Ameer-Beg, Melanie Keppler, Ton Coolen, Paul R. Barber, Borivoj Vojnovic, Klaus Suhling, Peter J. Parker, Hanna Milewicz, Michela Perani, Luis P. Fernandes
Publikováno v:
Science Signaling. 4
Natural killer (NK) cells kill tumor cells and virally infected cells, and an effective NK cell response requires processes, such as motility, recognition, and directional secretion, that rely on cytoskeletal rearrangement. The Rho guanosine triphosp
Autor:
Andrew J. Brooks, Michela Perani, Michael J. Waters, Philip Robinson, Becky L. Conway-Campbell
The presence of GH receptor (GHR) in the cell nucleus correlates with cell division, and targeting the GHR to the nucleus results in constitutive proliferation and transformation because of increased sensitivity to autocrine GH. Here we have sought a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2667a92c0ea03cf68541f0f9ef2ab376
https://europepmc.org/articles/PMC5419461/
https://europepmc.org/articles/PMC5419461/
Publikováno v:
FEMS microbiology letters. 160(1)
Of newly isolated colonies with the appearance of Bacillus thuringiensis, 47.5% were found to produce the parasporal crystals characteristic of this species. These positive isolates were screened using the polymerase chain reaction for their possessi
Autor:
Michela Perani, peter parker
Publikováno v:
King's College London
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3fc2aef462cf287a821861a1116d463b
https://kclpure.kcl.ac.uk/portal/en/publications/paving-a-new-era-of-personalized-medicine(58de3fc5-ccd5-4578-8af1-81e125bbb805).html
https://kclpure.kcl.ac.uk/portal/en/publications/paving-a-new-era-of-personalized-medicine(58de3fc5-ccd5-4578-8af1-81e125bbb805).html