Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth

Autor: Margot De Marco, Vanessa Gauttier, Sabrina Pengam, Caroline Mary, Bianca Ranieri, Anna Basile, Michela Festa, Antonia Falco, Francesca Reppucci, Anna Lisa Cammarota, Fausto Acernese, Vincenzo De Laurenzi, Gianluca Sala, Sergio Brongo, Masayuki Miyasaka, Shabnam Shalapour, Bernard Vanhove, Nicolas Poirier, Roberta Iaccarino, Michael Karin, Maria Caterina Turco, Alessandra Rosati, Liberato Marzullo

Publikováno v: Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)

Abstract The BAG3- and SIRPα- mediated pathways trigger distinct cellular targets and signaling mechanisms in pancreatic cancer microenvironment. To explore their functional connection, we investigated the effects of their combined blockade on cance

Externí odkaz: https://doaj.org/article/2e7a07aad6be4031b5911868e4714d63

Different mechanisms underlie IL-6 release in chemosensitive and chemoresistant ovarian carcinoma cells

Autor: Margot, De Marco, Antonia, Falco, Michela, Festa, Antonio, Raffone, Lucia, Sandullo, Alessandra, Rosati, Francesca, Reppucci, Anna Lisa, Cammarota, Franca, Esposito, Danilo Swann, Matassa, Maria, Pascale, Francesco, Salzano, Rosanna, Martinelli, Paolo, Remondelli, Mario, Capunzo, Antonio, Mollo, Fulvio, Zullo, Antonio, Travaglino, Maurizio, Guida, Liberato, Marzullo

Publikováno v: American journal of cancer research. 10(8)

Interleukin (IL)-6 has been detected in serum and ascites from patients affected by epithelial ovarian cancers, and also in some human ovarian cancer cell lines. To investigate the role of IL-6 in ovarian lesions, we first measured its levels in seru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d405e2a6b9964fb82a09292941f00b2f
https://pubmed.ncbi.nlm.nih.gov/32905525

Cycloartane glycosides from Astragalus plumosus var. krugianus and evaluation of their antioxidant potential

Autor: Ömer Koz, Anna Capasso, Nilüfer Denizli, Derya Gülcemal, Ibrahim Horo, Michela Festa, Milena Masullo, Özgen Alankuş-Çalışkan, Sonia Piacente

Publikováno v: Fitoterapia. 92:211-218

The methanol extracts of Astragalus plumosus var. krugianus Chamb. & Matthews afforded sixteen cycloartane glycosides among which krugianoside A, was never reported before. All compounds were evaluated for their cytotoxic activity in human skin fibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aee06c27b136f645fa439c5d1423a2
https://doi.org/10.1016/j.fitote.2013.10.018

The Involvement of Xanthohumol in the Expression of Annexin in Human Malignant Glioblastoma Cells

Autor: Cw D'Acunto, Michela Festa, Anna Capasso, Mf Tecce, Adriano G. Rossi, C Cipolla, Mariella Caputo

Publikováno v: The Open Biochemistry Journal
Festa, M, Caputo, M, Cipolla, C, D'Acunto, C, Rossi, A, Tecce, M & Capasso, A 2013, ' The involvement of xanthohumol in the expression of annexin in human malignant glioblastoma cells ', Open Biochemistry Journal, vol. 7, pp. 1-10 . https://doi.org/10.2174/1874091X01307010001

Glioblastoma multiforme (GBM) is the most common malignant and resistant tumor of the central nervous system in humans and new therapeutic strategies are urgently required. Recently, we have shown that the potential chemotherapeutic polyphenol xantho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15025969f0d711e034f72b2ff8340de7
https://doi.org/10.2174/1874091x01307010001

Interconverting flavanone glucosides and other phenolic compounds in Lippia salviaefolia Cham. ethanol extracts

Autor: Cosimo Pizza, Assunta Napolitano, Thais Gaban Passalacqua, Daniel Rinaldo, Giselda Durigan, Maria Claudia Marx Young, Sonia Piacente, Michela Festa, Anna Capasso, Dulce Helena Siqueira Silva, Cristiano Soleo Funari

Publikováno v: Phytochemistry. 72:2052-2061

Four interconverting flavanone glycosides [(2R)- and (2S)-3',4',5,6-tetrahydroxyflavanone 7-O-β-D-glucopyranoside, and (2R)- and (2S)-3',4',5,8-tetrahydroxyflavanone 7-O-β-D-glucopyranoside], in addition to eight known flavonoids [naringenin, asebo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c7e8a642a40a6b105971e82cd957b8
https://doi.org/10.1016/j.phytochem.2011.07.004