Výsledky vyhledávání - "Michela Aurilio"

Akademický článek

On site production of [18F]PSMA-1007 using different [18F]fluoride activities: practical, technical and economical impact

Autor: Costantina Maisto, Anna Morisco, Roberta de Marino, Elisabetta Squame, Valentina Porfidia, Laura D’Ambrosio, Daria Di Martino, Paolo Gaballo, Michela Aurilio, Monica Buonanno, Aureliana Esposito, Marco Raddi, Secondo Lastoria

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-10 (2021)

Abstract Background Prostate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission tomography/computed tomography imaging of primary cancer and recurrent/metastatic disease, as well as

Externí odkaz: https://doaj.org/article/e2ca2845be5a47a29b01e368124e5f72

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Akademický článek

Analysis of Pros and Cons in Using [68Ga]Ga-PSMA-11 and [18F]PSMA-1007: Production, Costs, and PET/CT Applications in Patients with Prostate Cancer

Autor: Costantina Maisto, Michela Aurilio, Anna Morisco, Roberta de Marino, Monica Josefa Buonanno Recchimuzzo, Luciano Carideo, Laura D’Ambrosio, Francesca Di Gennaro, Aureliana Esposito, Paolo Gaballo, Valentina Pirozzi Palmese, Valentina Porfidia, Marco Raddi, Alfredo Rossi, Elisabetta Squame, Secondo Lastoria

Publikováno v: Molecules, Vol 27, Iss 12, p 3862 (2022)

The aim of this work is to compare [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 PET/CT as imaging agents in patients with prostate cancer (PCa). Comparisons were made by evaluating times and costs of the radiolabeling process, imaging features including pharm

Externí odkaz: https://doaj.org/article/c437e6b3cd04488c8365d989227a1d91

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On site production of [18F]PSMA-1007 using different [18F]fluoride activities: practical, technical and economical impact

Autor: Secondo Lastoria, Daria Di Martino, Roberta de Marino, Elisabetta Squame, Aureliana Esposito, Paolo Gaballo, Anna Morisco, Valentina Porfidia, Marco Raddi, Monica Buonanno, Michela Aurilio, L. D'Ambrosio, Costantina Maisto

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-10 (2021)
EJNMMI Radiopharmacy and Chemistry

Background Prostate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission tomography/computed tomography imaging of primary cancer and recurrent/metastatic disease, as well as for radio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963685f27187f101b9da27e1f78e2a70
https://doaj.org/article/e2ca2845be5a47a29b01e368124e5f72

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Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors

Autor: Paolo Gaballo, Stefania Scala, Stefano Tomassi, Ettore Novellino, Caterina Ieranò, Sara Santagata, Secondo Lastoria, Crescenzo D'Alterio, Luigi Portella, Salvatore Di Maro, Deborah Sementa, Margret Schottelius, Daria Di Martino, Antonio Luciano, Antonio Barbieri, Luciana Marinelli, Michela Aurilio, Anna Maria Trotta

Publikováno v: Journal of medicinal chemistry. 64(6)

The recently reported CXCR4 antagonist 3 (Ac-Arg-Ala-[DCys-Arg-2Nal-His-Pen]-CO2H) was investigated as a molecular scaffold for a CXCR4-targeted positron emission tomography (PET) tracer. Toward this end, 3 was functionalized with 1,4,7,10-tetraazacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38989f64ee35964d54605725ce4e6c4
https://pubmed.ncbi.nlm.nih.gov/33660512

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Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist

Autor: Luigi Portella, Francesco Saverio Di Leva, Diego Brancaccio, Luciana Marinelli, Alfonso Carotenuto, Ettore Novellino, Anna Messere, Stefano Tomassi, Stefania Scala, Secondo Lastoria, Deborah Sementa, Michela Aurilio, Anna Maria Trotta, Salvatore Di Maro

Publikováno v: Journal of medicinal chemistry. 60(23)

In our ongoing pursuit of CXCR4 antagonists as potential anticancer agents, we recently developed a potent, selective and plasma stable peptide, Ac-Arg-Ala-[D-Cys-Arg-Phe-Phe-Cys]-COOH (3). Nevertheless, this compound was still not enough potent (IC5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d3911a8a9d777bb67a67a96f48dc17
https://pubmed.ncbi.nlm.nih.gov/29125295

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Radioimmunotherapy with Tenarad, a 131I-labelled antibody fragment targeting the extra-domain A1 of tenascin-C, in patients with refractory Hodgkin's lymphoma

Autor: Michela Aurilio, Francesca Di Gennaro, Corradina Caracò, Secondo Lastoria, Dario Neri, Gaetana Capobianco, Antonio Pinto, Leonardo Giovannoni, Luigi Aloj, Hans D. Menssen, L. D'Ambrosio, Anna Morisco, Ferdinando Frigeri

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 41:867-877

The extra-domain A1 of tenascin-C (TC-A1) is highly expressed in the extracellular matrix of tumours and on newly formed blood vessels and is thus a valuable target for radionuclide therapy. Tenarad is a fully human miniantibody or small immunoprotei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7875687182d41992d080d84b955be02e
https://doi.org/10.1007/s00259-013-2658-6

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Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors

Autor: Rosalba Mansi, Luigi Del Pozzo, Luigi Aloj, Giancarlo Morelli, Paola Ringhieri, Antonella Accardo, Michela Aurilio, Alberto Signore, Filippo Galli, Anna Morisco

Publikováno v: EJNMMI Research

BACKGROUND: Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabeled peptide-based ligands towar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e4ac8f79dbc81176c0344dcfa6b2ee
https://doi.org/10.1186/s13550-016-0175-x

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Gastrin and cholecystokinin peptide-based radiopharmaceuticals: an in vivo and in vitro comparison

Autor: Michela Aurilio, Laura Tarallo, Anna Lucia Tornesello, Antonella Accardo, Claudio Arra, Giancarlo Morelli, Luigi Aloj, Antonio Barbieri, Diego Tesauro

Publikováno v: Journal of Peptide Science. 17:405-412

The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest. In the search for the best CCK-2R binding peptides, we have synthesized, evaluated and compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ffd4ac4c95b4b7e9668e16664f80a77
https://doi.org/10.1002/psc.1327

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Evaluation of a CdTe semiconductor based compact gamma camera for sentinel lymph node imaging

Autor: Michela Esposito, Assunta S. Curion, Corradina Caracò, Michela Aurilio, Secondo Lastoria, Luigi Aloj, Paolo Russo, Giovanni Mettivier

Publikováno v: Medical Physics. 38:1547-1560

Purpose: The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e02c5db2637c437a7c4a43190f0e9cf
https://doi.org/10.1118/1.3555034

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