Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Michela Alessandra Denti"'
Publikováno v:
Cells, Vol 12, Iss 15, p 1959 (2023)
Nucleic acid therapeutics have demonstrated an impressive acceleration in recent years. They work through multiple mechanisms of action, including the downregulation of gene expression and the modulation of RNA splicing. While several drugs based on
Externí odkaz:
https://doaj.org/article/15d00a64d8a74ef0a4420bda832d8dc3
Autor:
Michele Castelluzzo, Alessio Perinelli, Simone Detassis, Michela Alessandra Denti, Leonardo Ricci
Publikováno v:
SoftwareX, Vol 12, Iss , Pp 100569- (2020)
The possibility of using microRNA (miRNA) levels as diagnostic and prognostic tools to detect different pathologies requires the implementation of reliable classifiers, whose training and use call for quality control of data corresponding to miRNA ex
Externí odkaz:
https://doaj.org/article/ba4451254fea408c8f68d54705d3b99e
miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples
Autor:
Simone Detassis, Valerio del Vescovo, Margherita Grasso, Stefania Masella, Chiara Cantaloni, Luca Cima, Alberto Cavazza, Paolo Graziano, Giulio Rossi, Mattia Barbareschi, Leonardo Ricci, Michela Alessandra Denti
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Lung cancer is still one of the leading cause of death worldwide. The clinical variability of lung cancer is high and drives treatment decision. In this context, correct discrimination of pulmonary neuroendocrine tumors is still of critical relevance
Externí odkaz:
https://doaj.org/article/25210183428346f3aa3123f8a96831b4
Autor:
Michela Masè, Margherita Grasso, Laura Avogaro, Manuel Nicolussi Giacomaz, Elvira D’Amato, Francesco Tessarolo, Angelo Graffigna, Michela Alessandra Denti, Flavia Ravelli
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Atrial stretch and dilatation are common features of many clinical conditions predisposing to atrial fibrillation (AF). MicroRNAs (miRs) are emerging as potential molecular determinants of AF, but their relationship with atrial dilatation (AD) is poo
Externí odkaz:
https://doaj.org/article/acf9203592aa4b0aa621f7622a4ff709
Autor:
Paola ePiscopo, Margherita eGrasso, Francesca eFontana, Alessio eCrestini, Maria ePuopolo, Valerio eDel Vescovo, Aldina eVenerosi, Gemma eCalamandrei, Sebastian F Vencken, Catherine M Greene, Annamaria eConfaloni, Michela Alessandra Denti
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and activated microglia. Loss-of-function mutations in the GRN gene are an important cause of familial Frontotempo
Externí odkaz:
https://doaj.org/article/635e4473fa2943f2be6170c5807e8fc0
Autor:
Lorenzo Ferri, Giuseppina Covello, Anna Caciotti, Renzo Guerrini, Michela Alessandra Denti, Amelia Morrone
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Fabry disease is a rare X-linked lysosomal storage disorder caused by deficiency of the α-galactosidase A (α-Gal A) enzyme, which is encoded by the GLA gene. GLA transcription in humans produces a major mRNA encoding α-Gal A and a minor mRNA of un
Externí odkaz:
https://doaj.org/article/45bdc5adde79431fa9379af7cd18a1cd
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2015)
Fronto Temporal Dementia (FTD) is a neurodegenerative disorder characterized by degeneration of the fronto temporal lobes and abnormal protein inclusions. It exhibits a broad clinicopathological spectrum and has been linked to mutations in seven diff
Externí odkaz:
https://doaj.org/article/3923f0be6acb4a05bd1b5a9025adfc37
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78870 (2013)
Non-coding RNAs play major roles in the translational control of gene expression. In order to identify disease-associated miRNAs in precursor lesions of lung cancer, RNA extracts from lungs of either c-Raf transgenic or wild-type (WT) mice were hybri
Externí odkaz:
https://doaj.org/article/85d4c729fae34e56987da0d7bb52cf3e
Publikováno v:
British Medical Bulletin.
Introduction Ribonucleic acid (RNA) therapeutics are a new class of drugs whose importance is highlighted by the growing number of molecules in the clinic. Sources of data We focus on RNA therapeutics for neurogenetic disorders, which are broadly def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01156bd560086904cd3b97fe6897b60c
https://doi.org/10.1093/bmb/ldad010
https://doi.org/10.1093/bmb/ldad010
Autor:
Giuseppina, Covello, Gehan H, Ibrahim, Niccolò, Bacchi, Simona, Casarosa, Michela Alessandra, Denti
Publikováno v:
Nucleic acid therapeutics. 32(4)
Inherited retinal dystrophies are caused by mutations in more than 250 genes, each of them carrying several types of mutations that can lead to different clinical phenotypes. Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ae2a8c86af5710ccaa85fff0b02549c
https://pubmed.ncbi.nlm.nih.gov/35166581
https://pubmed.ncbi.nlm.nih.gov/35166581