Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Michela A Denti"'
Autor:
Suzan M Hammond, Annemieke Aartsma‐Rus, Sandra Alves, Sven E Borgos, Ronald A M Buijsen, Rob W J Collin, Giuseppina Covello, Michela A Denti, Lourdes R Desviat, Lucía Echevarría, Camilla Foged, Gisela Gaina, Alejandro Garanto, Aurelie T Goyenvalle, Magdalena Guzowska, Irina Holodnuka, David R Jones, Sabine Krause, Taavi Lehto, Marisol Montolio, Willeke Van Roon‐Mom, Virginia Arechavala‐Gomeza
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Nucleic acid‐based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed products based
Externí odkaz:
https://doaj.org/article/76e52486fd764de6bb07b4e5106b079a
Autor:
Caroline Godfrey, Lourdes R Desviat, Bård Smedsrød, France Piétri‐Rouxel, Michela A Denti, Petra Disterer, Stéphanie Lorain, Gisela Nogales‐Gadea, Valentina Sardone, Rayan Anwar, Samir EL Andaloussi, Taavi Lehto, Bernard Khoo, Camilla Brolin, Willeke MC van Roon‐Mom, Aurélie Goyenvalle, Annemieke Aartsma‐Rus, Virginia Arechavala‐Gomeza
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 5, Pp 545-557 (2017)
Abstract The use of splice‐switching antisense therapy is highly promising, with a wealth of pre‐clinical data and numerous clinical trials ongoing. Nevertheless, its potential to treat a variety of disorders has yet to be realized. The main obst
Externí odkaz:
https://doaj.org/article/dc24c7db81c9430cadef6dc5077b7915
miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples
Autor:
Simone Detassis, Valerio del Vescovo, Margherita Grasso, Stefania Masella, Chiara Cantaloni, Luca Cima, Alberto Cavazza, Paolo Graziano, Giulio Rossi, Mattia Barbareschi, Leonardo Ricci, Michela Alessandra Denti
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Lung cancer is still one of the leading cause of death worldwide. The clinical variability of lung cancer is high and drives treatment decision. In this context, correct discrimination of pulmonary neuroendocrine tumors is still of critical relevance
Externí odkaz:
https://doaj.org/article/25210183428346f3aa3123f8a96831b4
Autor:
Paola Piscopo, Margherita Grasso, Valeria Manzini, Andrea Zeni, Michele Castelluzzo, Francesca Fontana, Giuseppina Talarico, Anna Elisa Castellano, Roberto Rivabene, Alessio Crestini, Giuseppe Bruno, Leonardo Ricci, Michela A. Denti
Publikováno v:
Frontiers in Molecular Neuroscience. 16
BackgroundDementia is one of the most common diseases in elderly people and hundreds of thousand new cases per year of Alzheimer’s disease (AD) are estimated. While the recent decade has seen significant advances in the development of novel biomark
Publikováno v:
British Medical Bulletin.
Introduction Ribonucleic acid (RNA) therapeutics are a new class of drugs whose importance is highlighted by the growing number of molecules in the clinic. Sources of data We focus on RNA therapeutics for neurogenetic disorders, which are broadly def
Autor:
Michela Masè, Margherita Grasso, Laura Avogaro, Manuel Nicolussi Giacomaz, Elvira D’Amato, Francesco Tessarolo, Angelo Graffigna, Michela Alessandra Denti, Flavia Ravelli
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Atrial stretch and dilatation are common features of many clinical conditions predisposing to atrial fibrillation (AF). MicroRNAs (miRs) are emerging as potential molecular determinants of AF, but their relationship with atrial dilatation (AD) is poo
Externí odkaz:
https://doaj.org/article/acf9203592aa4b0aa621f7622a4ff709
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 5 (2017)
Since their discovery and the advent of RNA interference, microRNAs have drawn enormous attention because of their ubiquitous involvement in cellular pathways from life to death, from metabolism to communication. It is also widely accepted that they
Externí odkaz:
https://doaj.org/article/a2788f8fbf5d4f25bd3c079fd1f3bc77
Publikováno v:
Molecules, Vol 19, Iss 5, Pp 6891-6910 (2014)
Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementias (FTD), are considered distinct entities, however, there is increasing evidence of an overlap from the clinical, pathological and
Externí odkaz:
https://doaj.org/article/c35084955301421c81f483560f7ed9e1
Autor:
Giuseppina, Covello, Gehan H, Ibrahim, Niccolò, Bacchi, Simona, Casarosa, Michela Alessandra, Denti
Publikováno v:
Nucleic acid therapeutics. 32(4)
Inherited retinal dystrophies are caused by mutations in more than 250 genes, each of them carrying several types of mutations that can lead to different clinical phenotypes. Mutations in
Autor:
Paola ePiscopo, Margherita eGrasso, Francesca eFontana, Alessio eCrestini, Maria ePuopolo, Valerio eDel Vescovo, Aldina eVenerosi, Gemma eCalamandrei, Sebastian F Vencken, Catherine M Greene, Annamaria eConfaloni, Michela Alessandra Denti
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and activated microglia. Loss-of-function mutations in the GRN gene are an important cause of familial Frontotempo
Externí odkaz:
https://doaj.org/article/635e4473fa2943f2be6170c5807e8fc0