Zobrazeno 1 - 10 of 86 pro vyhledávání: '"Michela, Pasello"'
1
Akademický článek
Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines
Autor: Chiara Casotti, Claudia Maria Hattinger, Maria Pia Patrizio, Silvia Luppi, Leonardo Fantoni, Michela Pasello, Katia Scotlandi, Toni Ibrahim, Massimo Serra
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related tox
Externí odkaz: https://doaj.org/article/8139d9c37b0e48caa53e1ce404be4871
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2
Akademický článek
Editorial: New therapies in the treatment of sarcomas
Autor: Alison Gartland, Michela Pasello, Frédéric Lézot, Francois Lamoureux
Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz: https://doaj.org/article/4ce71667c7a44c498e451028af9218af
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3
Akademický článek
Polymorphic variants of IGF2BP3 and SENCR have an impact on predisposition and/or progression of Ewing sarcoma
Autor: Marcella Martinelli, Caterina Mancarella, Luca Scapoli, Annalisa Palmieri, Paola De Sanctis, Cristina Ferrari, Michela Pasello, Cinzia Zucchini, Katia Scotlandi
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Ewing sarcoma (EWS), the second most common malignant bone tumor in children and adolescents, occurs abruptly without clear evidence of tumor history or progression. Previous association studies have identified some inherited variants associated with
Externí odkaz: https://doaj.org/article/6c93665eb071432c98f9d047c591bada
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4
Akademický článek
ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity
Autor: Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background The treatment of metastatic osteosarcoma (OS) remains a challenge for oncologists, and novel therapeutic strategies are urgently needed. An understanding of the pathways that regulate OS dissemination is required for the design of
Externí odkaz: https://doaj.org/article/5cd4ab50637442cbb9538299c71ce2ac
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5
Akademický článek
A 3D Collagen-Based Bioprinted Model to Study Osteosarcoma Invasiveness and Drug Response
Autor: Evelin Pellegrini, Giovanna Desando, Mauro Petretta, Antonella Cellamare, Camilla Cristalli, Michela Pasello, Maria Cristina Manara, Brunella Grigolo, Katia Scotlandi
Publikováno v: Polymers, Vol 14, Iss 19, p 4070 (2022)
The biological and therapeutic limits of traditional 2D culture models, which only partially mimic the complexity of cancer, have recently emerged. In this study, we used a 3D bioprinting platform to process a collagen-based hydrogel with embedded os
Externí odkaz: https://doaj.org/article/364e59854e5d436cb3f7ba7e26daac73
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6
Akademický článek
Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations
Autor: Patrizia Nanni, Lorena Landuzzi, Maria Cristina Manara, Alberto Righi, Giordano Nicoletti, Camilla Cristalli, Michela Pasello, Alessandro Parra, Marianna Carrabotta, Manuela Ferracin, Arianna Palladini, Marianna L. Ianzano, Veronica Giusti, Francesca Ruzzi, Mauro Magnani, Davide Maria Donati, Piero Picci, Pier-Luigi Lollini, Katia Scotlandi
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic regimes, which are largely unsuccessful in advanced patients. Preclinical models are needed to break this impasse. A panel of patient-derived xenografts (PDX) wa
Externí odkaz: https://doaj.org/article/520fd06572ac4ed78a2083b0e3a1fa0d
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8
Akademický článek
Impact of ABC Transporters in Osteosarcoma and Ewing’s Sarcoma: Which Are Involved in Chemoresistance and Which Are Not?
Autor: Massimo Serra, Claudia Maria Hattinger, Michela Pasello, Chiara Casotti, Leonardo Fantoni, Chiara Riganti, Maria Cristina Manara
Publikováno v: Cells, Vol 10, Iss 9, p 2461 (2021)
The ATP-binding cassette (ABC) transporter superfamily consists of several proteins with a wide repertoire of functions. Under physiological conditions, ABC transporters are involved in cellular trafficking of hormones, lipids, ions, xenobiotics, and
Externí odkaz: https://doaj.org/article/acfb63b2d0124ae78b77743acfe55850
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