Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Michela, Palmieri"'
Autor:
Hayley M. Sabol, Cody Ashby, Manish Adhikari, Aric Anloague, Japneet Kaur, Sharmin Khan, Samrat Roy Choudhury, Carolina Schinke, Michela Palmieri, C. Lowry Barnes, Elena Ambrogini, Intawat Nookaew, Jesus Delgado-Calle
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Multiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and
Externí odkaz:
https://doaj.org/article/55d0084f6d04406cb89cabefa045f8c2
Autor:
Qiang Fu, Nancy C. Bustamante-Gomez, Humberto Reyes-Pardo, Igor Gubrij, Diana Escalona-Vargas, Jeff D. Thostenson, Michela Palmieri, Joseph J. Goellner, Intawat Nookaew, C. Lowry Barnes, Jeffrey B. Stambough, Elena Ambrogini, Charles A. O’Brien
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Denosumab is an anti-RANKL Ab that potently suppresses bone resorption, increases bone mass, and reduces fracture risk. Discontinuation of denosumab causes rapid rebound bone resorption and bone loss, but the molecular mechanisms are unclear. We gene
Externí odkaz:
https://doaj.org/article/82f9bbc937414ac8a33804dad0b78c04
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Loss and gain of functions mutations in the X-linked MECP2 (methyl-CpG-binding protein 2) gene are responsible for a set of generally severe neurological disorders that can affect both genders. In particular, Mecp2 deficiency is mainly associated wit
Externí odkaz:
https://doaj.org/article/9eddaf42352246eebb79216d5f70ed2f
Autor:
Michela Palmieri, Teenamol E Joseph, Charles A O'Brien, Horacio Gomez-Acevedo, Stavros C Manolagas, Elena Ambrogini
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265893 (2022)
The scavenger receptor class B member 1 (SR-B1 or Scarb1) is a cell surface receptor for high density lipoproteins. It also binds oxidized low density lipoproteins and phosphocholine-containing oxidized phospholipids (PC-OxPL), which adversely affect
Externí odkaz:
https://doaj.org/article/f7ca9e8dac9840ffbf4b8011cc3abb3e
Autor:
Angelisa Frasca, Eleonora Spiombi, Michela Palmieri, Elena Albizzati, Maria Maddalena Valente, Anna Bergo, Barbara Leva, Charlotte Kilstrup‐Nielsen, Federico Bianchi, Valerio Di Carlo, Ferdinando Di Cunto, Nicoletta Landsberger
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Abstract Mutations in MECP2 cause several neurological disorders of which Rett syndrome (RTT) represents the best‐defined condition. Although mainly working as a transcriptional repressor, MeCP2 is a multifunctional protein revealing several activi
Externí odkaz:
https://doaj.org/article/b33103f72f62419ba99b856dddd50402
Autor:
Rituraj Pal, Michela Palmieri, Arindam Chaudhury, Tiemo Jürgen Klisch, Alberto di Ronza, Joel R. Neilson, George G. Rodney, Marco Sardiello
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The growth-promoting activity of mTORC1 is regulated by amino acid availability via the Rag GTPases. Here, the authors demonstrate Src-dependent control of cell size and autophagy through disruption of the Rag GTPase–GATOR1 complex and mTORC1 activ
Externí odkaz:
https://doaj.org/article/2878637528374367ad3c6859ef91cfca
Autor:
Myriam Mirza, Anna Vainshtein, Alberto DiRonza, Uma Chandrachud, Luke J. Haslett, Michela Palmieri, Stephan Storch, Janos Groh, Niv Dobzinski, Gennaro Napolitano, Carolin Schmidtke, Danielle M. Kerkovich
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 12, Pp n/a-n/a (2019)
Abstract Background One of the most important steps taken by Beyond Batten Disease Foundation in our quest to cure juvenile Batten (CLN3) disease is to understand the State of the Science. We believe that a strong understanding of where we are in our
Externí odkaz:
https://doaj.org/article/ff6be28e0b18473a86341a67a5838308
Autor:
Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose
Externí odkaz:
https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a
Autor:
Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications 8: Article number: 14338 (2017); Published: 6 February 2017; Updated: 13 June 2017 This Article contains errors in Figs 2 and 3, for which we apologize. In Fig. 2c, the four images were inadvertently duplicated from the images i
Externí odkaz:
https://doaj.org/article/ad88932b47944958b842a6eaf7d2a132
Autor:
Ching-On Wong, Michela Palmieri, Jiaxing Li, Dmitry Akhmedov, Yufang Chao, Geoffrey T. Broadhead, Michael X. Zhu, Rebecca Berdeaux, Catherine A. Collins, Marco Sardiello, Kartik Venkatachalam
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2009-2020 (2015)
Here, we evaluate the mechanisms underlying the neurodevelopmental deficits in Drosophila and mouse models of lysosomal storage diseases (LSDs). We find that lysosomes promote the growth of neuromuscular junctions (NMJs) via Rag GTPases and mechanist
Externí odkaz:
https://doaj.org/article/6e39c47238c748c48204c393897d63d0