Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Michela, Locci"'
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101840- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines drive the generation of affinity-matured B cell responses through germinal center (GC) reactions in vaccine draining lymph nodes. Herein, we describe a procedure for
Externí odkaz:
https://doaj.org/article/d3eddff344264261b03d248e52b2cc37
Autor:
Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Matthias G. Pauthner, Gabriel Ozorowski, Rafi Ahmed, Dennis R. Burton, Andrew B. Ward, Guido Silvestri, Shane Crotty, Michela Locci
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potentia
Externí odkaz:
https://doaj.org/article/6a342a2d376d40c9a622e807800f05fb
Autor:
Emily Bettini, Michela Locci
Publikováno v:
Vaccines, Vol 9, Iss 2, p 147 (2021)
To successfully protect against pathogen infection, a vaccine must elicit efficient adaptive immunity, including B and T cell responses. While B cell responses are key, as they can mediate antibody-dependent protection, T cells can modulate B cell ac
Externí odkaz:
https://doaj.org/article/4304d9f4e8ee4be6ab4f27c2cf7d9ca8
Autor:
Amy C. Palin, Galit Alter, Shane Crotty, Ali H. Ellebedy, M. Chelsea Lane, F. Eun-Hyung Lee, Michela Locci, Angela Malaspina, Conrad Mallia, M. Juliana McElrath, Bali Pulendran, Anjali Singh, M. Patricia D’Souza
Publikováno v:
Nat Immunol
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156074 (2016)
SAP (SH2D1A) is required intrinsically in CD4 T cells to generate germinal center responses and long-term humoral immunity. SAP binds to SLAM family receptors, including SLAM, CD84, and Ly108 to enhance cytokine secretion and sustained T cell:B cell
Externí odkaz:
https://doaj.org/article/fc5e30af98664cb096a6a1e59e2dbaf3
Autor:
Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Sonia Ndeupen, Chutamath Sittplangkoon, Joel R. Wilmore, Brian T. Gaudette, Ousamah Y. Soliman, Matthew Pine, Philip Hicks, Tomaz B. Manzoni, James J. Knox, John L. Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M. Rosenfeld, Shirin Strohmeier, Paulo J.C. Lin, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P. Cancro, Drew Weissman, Eline T. Luning Prak, David Allman, Botond Z. Igyártó, Michela Locci, Norbert Pardi
Publikováno v:
Immunity
Adjuvants are critical for improving the quality and magnitude of adaptive immune responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against SARS-CoV-2, but the mechanism of act
Autor:
Joe Craft, Alec W. Freyn, Hongyu Zhao, Steven H. Kleinstein, Davide Angeletti, Yisi Lu, Kevin C. O’Connor, Katlyn Lederer, Jiawei Wang, Roy Jiang, Michela Locci, Raffael Nachbagauer, Shirin Strohmeier
Publikováno v:
The Journal of Experimental Medicine
Seasonal influenza virus infections cause severe illness and a substantial number of deaths worldwide every year. This study reveals that the CD4+ follicular regulatory T cells are necessary for optimal antigen-specific humoral immunity following inf
Autor:
Lizhou Zhang, Maciel Porto, Norbert Pardi, Katalin Karikó, Gregory D. Sempowski, Brian T. Gaudette, Sushila A. Toulmin, Hyeryun Choe, Tracey Ann Campbell, Tammy Putman-Taylor, Leslee Arwood, Barton F. Haynes, Michael Farzan, Katlyn Lederer, Kevin O. Saunders, Hanne Leth Andersen, Florian Krammer, Paul Bates, Brianne Roper, Laurent Pessaint, Dorottya Laczkó, Amanda Strasbaugh, Thomas H. Oguin, Jack Greenhouse, Diana Castaño, Michael J. Hogan, Fatima Amanat, Shirin Strohmeier, Laurence C. Eisenlohr, Amrita Ojha, Michela Locci, Raffael Nachbagauer, David Allman, István Tombácz, Tomaz B. Manzoni, Robert Parks, Paulo J.C. Lin, Zekun Mu, Drew Weissman, Hiromi Muramatsu, Philip Hicks, Ying K. Tam
Publikováno v:
Immunity
Summary SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high transmissibility of the virus and the high rate of morbidity and mortality associated with COVID-19, developing effective and safe vaccines is a top research p
Autor:
Katlyn Lederer, Emily Bettini, Kalpana Parvathaneni, Mark M. Painter, Divyansh Agarwal, Kendall A. Lundgreen, Madison Weirick, Kavitha Muralidharan, Diana Castaño, Rishi R. Goel, Xiaoming Xu, Elizabeth M. Drapeau, Sigrid Gouma, Jordan T. Ort, Moses Awofolaju, Allison R. Greenplate, Carole Le Coz, Neil Romberg, Jennifer Trofe-Clark, Gregory Malat, Lisa Jones, Mark Rosen, Daniela Weiskopf, Alessandro Sette, Behdad Besharatian, Mary Kaminiski, Scott E. Hensley, Paul Bates, E. John Wherry, Ali Naji, Vijay Bhoj, Michela Locci
Publikováno v:
Cell
medRxiv
medRxiv
Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy
Autor:
Norbert Pardi, Kendall A. Lundgreen, Laurence C. Eisenlohr, Tomaz B. Manzoni, Sidney Wang, Katlyn Lederer, Florian Krammer, Paul Bates, Diana Castaño, Ivan Maillard, Drew Weissman, Hiromi Muramatsu, Steven H.Y. Fan, Michael J. Hogan, Gregory D. Sempowski, Daniela Gómez Atria, Michela Locci, Thomas H. Oguin, Patrick Cherubin, Fatima Amanat, Ying K. Tam
Publikováno v:
Immunity
The deployment of effective vaccines against SARS-CoV-2 is critical to eradicate the COVID-19 pandemic. Many licensed vaccines confer protection by inducing long-lived plasma cells (LLPC) and memory B cells (MBC), cell types canonically generated dur