Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Michel de Waard"'
Autor:
Sarah O. Rodrigues, Felipe R. Santiago, Monique S. Silva, Alex Sandro G. Lima, Lidiane E. Godoy, Michel De Waard, Dalia Fouad, Gaber E. Batiha, Tamara L. Santos, Jorge P. Pagnossa
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117437- (2024)
During the Covid-19 pandemic period, the indiscriminate use of macrolide-class antibiotics was frequent among the Brazilian population due to the lack of knowledge and information with a scientific basis. Thus, the class of drugs that includes azithr
Externí odkaz:
https://doaj.org/article/675785a993ef42f48c55ba8f2e10105e
Autor:
Halimat Yusuf Lukman, Yucheng Kuo, Mayowa Solomon Owolabi, Bashir Lawal, Lung-Ching Chen, Olabode T. Ajenifujah, Adewale O. Fadaka, Femi Olawale, Sunday A. Onikanni, Saidu Sani, Michel De Waard, Dalia Fouad, Gaber El-Saber Batiha, Saheed Sabiu, Alexander T.H. Wu, Hsu-Shan Huang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117308- (2024)
The continual increase in global diabetic statistics portends decreased productivity and life spans, thus making it a disease of concern requiring more effective and safe therapeutic options. While several reports on antidiabetic plants, including Hu
Externí odkaz:
https://doaj.org/article/49a041303cf04296a6f7fa03647e1149
Autor:
Fatima Abbas, Laila Ananda Blömer, Hugo Millet, Jérôme Montnach, Michel De Waard, Marco Canepari
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The toxin AaH-II, from the scorpion Androctonus australis Hector venom, is a 64 amino acid peptide that targets voltage-gated Na+ channels (VGNCs) and slows their inactivation. While at macroscopic cellular level AaH-II prolongs the action p
Externí odkaz:
https://doaj.org/article/5d40da4c74674c8db64b1ca1d5f6f80d
Autor:
Ngozi Dorathy Idoko, Ifeoma Felicia Chukwuma, Florence Nkechi Nworah, Sopuruchukwu Elizabeth Mba, Parker Elijah Joshua, Okwesilieze Fred Chiletugo Nwodo, Wafaa Fouzi Abusudah, Najlaa Hamed Almohmadi, Michel de Waard
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Immunological abnormalities are implicated in the pathogenesis of many chronic diseases. Due to the drug-related adverse effects of currently available orthodox immunomodulators, natural immunomodulators are being looked upon as p
Externí odkaz:
https://doaj.org/article/1314216fb30641578c2aa35cbd40c8bd
Autor:
Rym ElFessi, Oussema Khamessi, Michel De Waard, Najet Srairi-Abid, Kais Ghedira, Riadh Marrouchi, Riadh Kharrat
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10472 (2024)
Maurotoxin (MTX) is a 34-residue peptide from Scorpio maurus venom. It is reticulated by four disulfide bridges with a unique arrangement compared to other scorpion toxins that target potassium (K+) channels. Structure–activity relationship studies
Externí odkaz:
https://doaj.org/article/d80d50e692894ef38e86b936932256b4
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type calcium channels. Recently, a new heterozygous missense mutation in the CACNA1H gene that en
Externí odkaz:
https://doaj.org/article/f558935862cf41128a425c662d031105
Autor:
Hammad Ismail, Zaryab Mubashar, Hajra Khan, Zeenat Naveed, Erum Dilshad, Muhammad Zeeshan Bhatti, Sadaf Anwaar, Samreen Saleem, Sabba Mehmood, Abdur Rahman, Umer Rashid, Dalia Fouad, Michel De Waard, Gaber El-Saber Batiha
Publikováno v:
Metabolites, Vol 14, Iss 8, p 442 (2024)
Trans fatty acids are specific unsaturated fats found in processed foods that undergo hydrogenation, leading to hepatic disorders such as metabolic-associated fatty liver disease (MAFLD) and conditions like CVD and CKD. The effects of different food
Externí odkaz:
https://doaj.org/article/7c0a533867eb4b7aa9c9f96b8c65e7f8
Autor:
Aurélie Antunes, Philippe Robin, Gilles Mourier, Rémy Béroud, Michel De Waard, Denis Servent, Evelyne Benoit
Publikováno v:
Toxins, Vol 16, Iss 8, p 359 (2024)
Crotalphine is an analgesic peptide identified from the venom of the South American rattlesnake Crotalus durissus terrificus. Although its antinociceptive effect is well documented, its direct mechanisms of action are still unclear. The aim of the pr
Externí odkaz:
https://doaj.org/article/524662705e6c4a18aea0182918bfc9e6
Autor:
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Sumaiah J. Alarfaj, Rasha Khalifah Al-Akeel, Hani Faidah, Maisra M. El-Bouseary, Jean-Marc Sabatier, Michel De Waard, Thanaa A. El-Masry, Gaber El-Saber Batiha
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Patients with coronavirus disease 2019 (COVID-19) were shown to have reduced serum testosterone levels compared to healthy individuals. Low testosterone levels are linked with the development of erectile dysfunction (ED). In this case-contro
Externí odkaz:
https://doaj.org/article/7d483657877c4e608b497c423f22d276
Autor:
Ludivine Lopez, Stephan De Waard, Hervé Meudal, Cécile Caumes, Kuldip Khakh, Steve Peigneur, Barbara Oliveira-Mendes, Sophia Lin, Jolien De Waele, Jérôme Montnach, Sandrine Cestèle, Agnès Tessier, J.P. Johnson, Massimo Mantegazza, Jan Tytgat, Charles Cohen, Rémy Béroud, Frank Bosmans, Céline Landon, Michel De Waard
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115173- (2023)
Nav1.1 is an important pharmacological target as this voltage-gated sodium channel is involved in neurological and cardiac syndromes. Channel activators are actively sought to try to compensate for haploinsufficiency in several of these pathologies.
Externí odkaz:
https://doaj.org/article/00c037522f374110a6181eefd130b12d