Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Michel Y Braun"'
Autor:
Marie Bettonville, Stefania d'Aria, Kathleen Weatherly, Paolo E Porporato, Jinyu Zhang, Sabrina Bousbata, Pierre Sonveaux, Michel Y Braun
Publikováno v:
eLife, Vol 7 (2018)
Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes
Externí odkaz:
https://doaj.org/article/aed204a8703e421592db34ec9e265792
Autor:
Jinyu Zhang, Michel Y Braun
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145237 (2015)
We previously identified heme oxygenase 1 (HO-1) as a specific target of miR-155, and inhibition of HO-1 activity restored the capacity of miR-155-/- CD4+ T cells to promote antigen-driven inflammation after adoptive transfer in antigen-expressing re
Externí odkaz:
https://doaj.org/article/0fa9d1d00c814d66a6702fd9e32707c7
Autor:
Michel Y. Braun
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6779 (2021)
The cells of the immune system, particularly the T lymphocytes, have two main features that distinguish them from the cells of other tissues. They proliferate after activation and have the ability to move in tissues and organs. These characteristics
Externí odkaz:
https://doaj.org/article/085f3b65e34e4a52b0a669979cf0df7a
Autor:
Sabrina Bousbata, Kathleen Weatherly, Marie Bettonville, Stefania d'Aria, Pierre Sonveaux, Paolo E. Porporato, Michel Y Braun, Jinyu Zhang
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife, 7
eLife
eLife, 7
Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes
Autor:
Sabrina Bousbata, Kathleen Weatherly, Paolo E. Porporato, Jinyu Zhang, Pierre Sonveaux, Michel Y Braun, Marie Bettonville, Stefania d'Aria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7113bf8bb02edaccee0e0a9a7f91ef
https://doi.org/10.7554/elife.30938.016
https://doi.org/10.7554/elife.30938.016
Autor:
Marie Bettonville, Kathleen Weatherly, David Torres, Arnaud Köhler, Michel Y Braun, Stanislas Goriely
Publikováno v:
Immunity, inflammation and disease, 3 (4
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease
The protein S100A4 is best known for its significant role in promoting motility and invasive capacity of cancer cells. Since S100A4 expression has been reported also in T cells, we analyzed its potential role in T cell motility and inflammation. Usin
Autor:
Marie Bettonville, Patricia Vandevenne, Merry Van Puyvelde, Michel Y Braun, Kathleen Weatherly, Haifa Hamdi, Alessandro Zucchi, Jinyu Zhang
Publikováno v:
European Journal of Immunology. 45:829-842
T cells chronically stimulated by a persistent antigen often become dysfunctional and lose effector functions and proliferative capacity. To identify the importance of micro-RNA-155 (miR-155) in this phenomenon, we analyzed mouse miR-155-deficient CD
Autor:
Michel Y Braun, Jinyu Zhang
Publikováno v:
International immunology, 26 (7
MiR-155 (-/-) mice are highly resistant to experimental autoimmune encephalomyelitis (EAE), while Pdcd1 (-/-) mice develop a more severe form of the disease. To determine the conflicting roles of these two molecules in the disease, we generated miR-1
Autor:
Stéphane De Craeye, Sushila D'Souza, Sophie Detienne, Vijay Morampudi, Michel Y Braun, Alain Le Moine
Publikováno v:
Microbes and infection, 13
CD4+CD25+Foxp3+ T regulatory (Treg) cells, are known to regulate responses to infectious agents. Here we compared disease progression in BALB/c and C57BL/6(B6) mice infected perorally with Toxoplasma gondii for 7 days and examined the affect of parti
Autor:
Kathleen Weatherly, Isabelle Salmon, Michel Y Braun, Marc Hazzan, Florence Gaudray, Magali Noval Rivas
Publikováno v:
The Journal of immunology, 184 (12
CD3-negative NK cells are granular lymphocytes capable of producing inflammatory cytokines and killing malignant, infected, or stressed cells. We have recently observed a new role for NK cells in the control of the proliferation of CD4 T cells under