Pharmacological screening of bryophyte extracts that inhibit growth and induce abnormal phenotypes in human HeLa cancer cells

Autor: Michel Wright, Lucie Krzaczkowski, Chantal Etievant, Georges Massiot, Delphine Reberioux, Jean Edouard Gairin

Publikováno v: Fundamental & Clinical Pharmacology. 23:473-482

Antitumor activities of substances from natural sources apart from vascular plants and micro-organisms have been poorly investigated. Here we report on a pharmacological screening of a bryophyte extract library using a phenotypic cell-based assay rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bc30d5aedfd1e23d9323a64e7af390
https://doi.org/10.1111/j.1472-8206.2009.00698.x

Antiproliferative activity and phenotypic modification induced by selected Peruvian medicinal plants on human hepatocellular carcinoma Hep3B cells

Autor: Cedric Lavergne, Jean Edouard Gairin, Valérie Jullian, Maëlle Carraz, Geneviève Bourdy, Michel Wright, Mercedes Gonzales de la Cruz

Publikováno v: Journal of Ethnopharmacology
Journal of Ethnopharmacology, Elsevier, 2015, 166, pp.185-199. ⟨10.1016/j.jep.2015.02.028⟩
Journal of Ethnopharmacology, 2015, 166, pp.185-199. ⟨10.1016/j.jep.2015.02.028⟩

Ethnopharmacological relevance The high incidence of human hepatocellular carcinoma (HCC) in Peru and the wide use of medicinal plants in this country led us to study the activity against HCC cells in vitro of somes species used locally against liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49551b170741968bb07bd81c13648fec
http://hdl.handle.net/20.500.12278/27360

Gamma-Tubulin and MTOCs in

Autor: Catherine Klotz, Michel Wright, Françoise Rulz, Pascale Dupuid-Williams, Janine Beisson, Nicole Garreau de Loubresse

Publikováno v: Protist. 154:193-209

Summary The characterization of the two Paramecium γ-tubulin genes, γPT1 and γPT2, allowed us to raise Paramecium-specific antibodies, directed against their most divergent carboxy-terminal peptide and to analyze the localization and dynamics of �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34759fda0a7a01ca7a854ead0f9f775b
https://doi.org/10.1078/143446103322166509

Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties

Autor: Li-He Zhang, Michèle Garès, Ji-Mei Min, Michel Wright, Min Li, Jing-Rong Ciu, Kui Wang, Jean Cros, Ying Ye, Jeanne Leung-Tack

Publikováno v: Carcinogenesis. 23:573-579

Ajoene, a garlic stable oil-soluble sulfur rich compound was generally isolated as a mixture of two isomers [(E, Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide]. It has been described essentially as a potent inhibitor of platelet aggregation in vitro a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8956fc608d13b4cd63e3817172ab347b
https://doi.org/10.1093/carcin/23.4.573

Differential in vitro association of vinca alkaloid-induced tubulin spiral filaments into aggregated spirals

Autor: Michèle Garès, Michel Wright, Pascal Verdier-Pinard

Publikováno v: Biochemical Pharmacology. 58:959-971

Vinblastine, vincristine, vindesine, and vinorelbine, the four vinca alkaloids used in cancer therapy, differ in their antitumoral spectra and toxicities, but not in their inhibitory effects on microtubule assembly in vitro. At higher drug concentrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8fdf2d28e624670b905b0f1ba753a1
https://doi.org/10.1016/s0006-2952(99)00190-2