Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Michel Warny"'
Publikováno v:
Journal of Pharmaceutical Sciences. 97:4194-4207
To enhance the physical stability of Clostridium difficile toxoids A and B, screening for stabilizing compounds was performed. The screening of 30 GRAS compounds at various concentrations and in several combinations was performed in two parts. First,
Autor:
Michel Warny, Philippe A. Tessier, Fethia Ben Yebdri, Filip Kukulski, Julie S. Lefebvre, Jean Sévigny
Publikováno v:
Journal of Leukocyte Biology. 81:1269-1275
Extracellular nucleotides are emerging as important inflammatory mediators. Here, we demonstrate that these molecules mediate LPS-induced neutrophil migration in vitro and in vivo. Apyrase, a nucleotide scavenger, reduced the ability of LPS-stimulate
Autor:
Eric Frost, Jacques Pépin, Michel Warny, Jon S. Brazier, L. Clifford McDonald, George Killgore, Aiqi Fang, Angela Thompson
Publikováno v:
The Lancet. 366:1079-1084
Summary Background Toxins A and B are the primary virulence factors of Clostridium difficile . Since 2002, an epidemic of C difficile -associated disease with increased morbidity and mortality has been present in Quebec province, Canada. We character
Autor:
Sarah Keates, Paul J. Giannasca, Ciaran P. Kelly, Charalabos Pothoulakis, Cynthia K. Lee, Lorraine Kyne, Seema Maroo, Michel Warny, D. Drudy, Thomas P. Monath, Stavros Sougioultzis
Publikováno v:
Gastroenterology. 128:764-770
Background & aims: Recurrent C difficile-associated diarrhea (CDAD) is associated with a lack of protective immunity to C difficile toxins. A parenteral C difficile vaccine containing toxoid A and toxoid B was reported previously to be safe and immun
Autor:
Brian O'Sullivan, Steven D. Freedman, Meredith M. Regan, Michel Warny, Munir M. Zaman, Ciaran P. Kelly, Andres Gelrud, Omer Junaidi, Julie C. Shea
Publikováno v:
Clinical and Vaccine Immunology. 11:819-824
Patients with cystic fibrosis (CF) exhibit an excessive host inflammatory response. The aim of this study was to determine (i) whether interleukin 8 (IL-8) secretion is increased from monocytes from subjects heterozygous as well as homozygous for cys
Autor:
Michel Warny, Paul J. Giannasca
Publikováno v:
Vaccine. 22:848-856
Clostridium difficile, a gram-positive bacterium, is the major cause of hospital-acquired infectious diarrhea and colitis in industrialized nations. C. difficile colonization results from antibiotic administration and subsequent loss of protection pr
Autor:
Michel Warny, Ciaran P. Kelly
Pathogenic strains of Clostridium difficile cause diarrhea and colitis in humans through the release of two protein exotoxins, toxin A and toxin B. This chapter reviews the mechanisms whereby these toxins exert their cytotoxic, enterotoxic, and proin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e4c6eeef894cd98d814c6f7453e1dcd
https://doi.org/10.1128/9781555817848.ch27
https://doi.org/10.1128/9781555817848.ch27
Autor:
Simon C. Robson, Christian Goepfert, Yuan Lin, Michel Warny, Elzbieta Kaczmarek, Masato Imai, Jean Sévigny, Keiichi Enjyoji
Publikováno v:
Drug Development Research. 53:193-207
Extracellular nucleotide stimulation of purinergic/pyrimidinergic type-2 (P2) receptors are components of platelet, endothelial cell (EC), and leukocyte activation that culminate in vascular thrombosis and inflammation in vivo. CD39, the prototype nu
Autor:
Pierre Michetti, Michel Warny, Samer Aboudola, Ciaran P. Kelly, J. Thomas Lamont, C Pothoulakis, Amir A. Qamar
Publikováno v:
Infection and Immunity. 69:2762-2765
Saccharomyces boulardiiis a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrentClostridium difficilecolitis. The administration ofC. difficiletoxoid A by gavage toS. boulardii-fed BALB/c mice caused a 1.8-fold incre
Autor:
J. Thomas Lamont, Ciaran P. Kelly, Michel Warny, Ignazio Castagliuolo, Jeff K. Zacks, Andrew C. Keates, Samer Aboudola, Amir A. Qamar, C Pothoulakis, Sarah Keates
Publikováno v:
Scopus-Elsevier
Clostridium difficile toxin A causes acute neutrophil infiltration and intestinal mucosal injury. In cultured cells, toxin A inactivates Rho proteins by monoglucosylation. In monocytes, toxin A induces IL-8 production and necrosis by unknown mechanis