Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Michel Vandeputte"'
Publikováno v:
Transplantation. :1695-1704
Background. Pretransplant blood transfusions have beneficial effects on both clinical and experimental allograft survival. In the present study, we examined whether pretransplant hamster blood transfusions (pHBT) alone or together with peritransfusio
Autor:
B Degrève, Michel Vandeputte, Sigrid Hatse, Jan Balzarini, Lieve Naesens, E. De Clercq, Constant Segers, Mark Waer
Publikováno v:
ResearcherID
The acyclic nucleoside phosphonate 9-(2-phosphonyl-methoxyethyl)adenine (PMEA) is a potent and selective antiretroviral agent which is currently evaluated in its oral prodrug form, bis(POM)PMEA (adefovir dipivoxil), in phase II and III clinical trial
Publikováno v:
Transplantation. 65:340-345
Background. We have shown previously that a 2-week course of leflunomide (LF) together with a maintenance therapy of cyclosporine (CsA) rendered hamster-to-rat heart xenografts (Xg) resistant against anti-hamster IgM xenoantibody (XAb)-mediated rejec
Publikováno v:
Nature Medicine. 4:173-180
After transplantation of primarily vascularized xenografts (Xgs), T-independent mechanisms may lead to Xg rejection before T-cell activation even takes place. The possibility of achieving T-independent xenotolerance was evaluated in nude rats that no
Publikováno v:
Transplantation. 64:1677-1683
Background When hyperacute rejection, involving natural xenoreactive antibodies (XAb) and/or complement (C), can be prevented, xenografts (Xgs) undergo delayed xenograft rejection associated with a progressive mononuclear cell infiltration. We have p
Publikováno v:
Transplantation. 63:1705-1712
Background. Factors that contribute to xenograft (Xg) rejection were investigated in complement C6-deficient (C-) PVG rats. Methods. First and second hamster hearts were transplanted in C6-deficient and C6-sufficient PVG rats. Xenoantibody (XAb) form
Publikováno v:
ResearcherID
Polyomavirus infections in humans are due to BK virus (BKV) and JC virus (JCV). Diseases associated with human polyomaviruses occur mostly in immunocompromised adults, e.g., progressive multifocal leukoencephalopathy (PML), caused by JCV, in AIDS pat
Publikováno v:
Journal of Neuroimmunology. 61:151-160
The hormone 1 α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) has immune modulatory activities in vitro and in vivo, and can prevent or delay the onset of experimental or spontaneous autoimmune diseases. At therapeutical doses, however, hypercalcemic si
Autor:
J. Goebels, Sigrid Hatse, E. De Clercq, Jan Balzarini, Michel Vandeputte, H. Sobis, Annemieke Verstuyf
Publikováno v:
International Journal of Cancer. 61:130-137
9-(2-phosphonylmethoxyethyl)adenine (PMEA) is the prototype compound of a series of acyclic nucleoside phosphonate derivatives endowed with potent and selective anti-retroviral activity in vitro and in vivo. We have now found that PMEA is also a pote
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases. 12:269-279
The efficacy of HPMPC and DHPG against systemic and intracerebral murine cytomegalovirus (MCMV) infections was examined in immunocompetent NMRI mice and in mice with severe combined immunodeficiency (SCID). HPMPC proved to be far superior to DHPG in