Human Smc5/6 recognises transcription-generated positive DNA supercoils

Autor: Aurélie Diman, Gaël Panis, Cédric Castrogiovanni, Julien Prados, Bastien Baechler, Michel Strubin

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which

Externí odkaz: https://doaj.org/article/102454fb40ea491b972ca2cae402cd59

Author Correction: Smc5/6 silences episomal transcription by a three-step function

Autor: Fabien Abdul, Aurélie Diman, Bastien Baechler, Dhivya Ramakrishnan, Dmytro Kornyeyev, Rudolf K. Beran, Simon P. Fletcher, Michel Strubin

Publikováno v: Nature Structural & Molecular Biology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1ce7c09f6df42a381b8068ca418f1ea
https://doi.org/10.1038/s41594-023-01009-4

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.

Autor: Congrong Niu, Christine M Livingston, Li Li, Rudolf K Beran, Stephane Daffis, Dhivya Ramakrishnan, Dara Burdette, Leanne Peiser, Eduardo Salas, Hilario Ramos, Mei Yu, Guofeng Cheng, Michel Strubin, William E Delaney, Simon P Fletcher

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169648 (2017)

The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing HBV X protein (HBx), which targets Smc5/6 for degradation. However

Externí odkaz: https://doaj.org/article/289b65f6ddb14f2da1dab20a156f9d07

Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci

Autor: Amanda L. Hughes, Sari Kassem, Paolo Ferrari, Michel Strubin, Julien Soudet, Oliver J. Rando

Publikováno v: Science Advances, Vol. 6, No 36 (2020) P. eabb0333
Science Advances

Histone turnover during gene transcription is mediated by regulatory proteins, not by the transcription machinery.
Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9707318953a5449e027b6fd189b081
https://doi.org/10.1126/sciadv.abb0333

Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals

Autor: Alexia Paturel, Fabien Filleton, Laetitia Gerossier, Janet E. Hall, Fabien Abdul, Lucie Etienne, Michel Strubin

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2018, 92 (16), ⟨10.1128/JVI.00769-18⟩
Journal of Virology, 2018, 92 (16), ⟨10.1128/JVI.00769-18⟩
Journal of Virology, Vol. 92, No 16 (2018) pp. e00769-18

International audience; Chronic infection with hepatitis B virus (HBV) is a major cause of liver disease and cancer in humans. HBVs (family Hepadnaviridae) have been associated with mammals for millions of years. Recently, the Smc5/6 complex, known f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1225137b99535bc394d05ba2e9ea7bc
https://hal.archives-ouvertes.fr/hal-01911198