Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Michel Streuli"'
Autor:
Mikhail Binnewies, Joshua L. Pollack, Joshua Rudolph, Subhadra Dash, Marwan Abushawish, Tian Lee, Nadine S. Jahchan, Pamela Canaday, Erick Lu, Manith Norng, Shilpa Mankikar, Victoria M. Liu, Xiaoyan Du, Amanda Chen, Ranna Mehta, Rachael Palmer, Vladislava Juric, Linda Liang, Kevin P. Baker, Leonard Reyno, Matthew F. Krummel, Michel Streuli, Venkataraman Sriram
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109844- (2021)
Summary: Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires identifying suppressive mechanisms. We identify TREM2+ tumor-associated macrophages (TAMs) as being correlated with exhausted CD8+ tumor-infiltrating ly
Externí odkaz:
https://doaj.org/article/89538d76cb434b40949e243939171a38
Autor:
Laurence Fayadat-Dilman, Christine Andrews, Gulesi Ayanoglu, Liming Liu, Robert A. Kastelein, Aarron T. Willingham, Sabine Le Saux, Svetlana Sadekova, Dan Malashock, Hans van Eenennaam, Sophie Li, Ying Yu, Soonmo Peter Kang, Beth Hutchins, Andrea van Elsas, John Dulos, Rene De Waal Malefyt, Julie Lee, Frederique M. Poulet, Gregory J. Carven, Constance Cullen, Gary C. Starling, Mark Hsieh, Danuta J. Herzyk, Michel Streuli, Mark A. McCoy, George Soder
Publikováno v:
Molecular Cancer Therapeutics. 19:1298-1307
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
Tian Lee, Ranna Mehta, Marwan Abushawish, Manith Norng, Matthew F. Krummel, Kevin P. Baker, Linda Liang, Joshua Rudolph, Shilpa Mankikar, Xiaoyan Du, Victoria M. Liu, Nadine Jahchan, Amanda Chen, Rachael Palmer, Subhadra Dash, Erick Lu, Mikhail Binnewies, Venkataraman Sriram, Pamela Canaday, Joshua L. Pollack, Leonard Reyno, Vladislava Juric, Michel Streuli
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109844-(2021)
Summary: Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires identifying suppressive mechanisms. We identify TREM2+ tumor-associated macrophages (TAMs) as being correlated with exhausted CD8+ tumor-infiltrating ly
Autor:
Manith Norng, Subhadra Dash, Joshua L. Pollack, Rachael Palmer, Nadine Jahchan, Marwan Abushawish, Tian Lee, Ranna Mehta, Matthew F. Krummel, Linda Liang, Amanda Chen, Joshua Rudolph, Erick Lu, Venkataraman Sriram, Xiaoyan Du, Pamela Canaday, Mikhail Binnewies, Leonard Reyno, Shilpa Mankikar, Vladislava Juric, Michel Streuli, Victoria Liu
Publikováno v:
SSRN Electronic Journal.
Converting checkpoint inhibitor (CPI) resistant patients to responsive requires identifying novel suppressive mechanisms. We identified TREM2 + tumor associated macrophages (TAMs) as being correlated with exhausted CD8 + tumor infiltrating lymphocyte
Autor:
Beth, Hutchins, Gary C, Starling, Mark A, McCoy, Danuta, Herzyk, Frederique M, Poulet, John, Dulos, Liming, Liu, Soonmo Peter, Kang, Laurence, Fayadat-Dilman, Mark, Hsieh, Christine L, Andrews, Gulesi, Ayanoglu, Constance, Cullen, Rene de Waal, Malefyt, Robert A, Kastelein, Sabine Le, Saux, Julie, Lee, Sophie, Li, Dan, Malashock, Svetlana, Sadekova, George, Soder, Hans, van Eenennaam, Aarron, Willingham, Ying, Yu, Michel, Streuli, Gregory J, Carven, Andrea, van Elsas
Publikováno v:
Molecular cancer therapeutics. 19(6)
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Publikováno v:
Biochemistry. 44:15715-15724
The LAR transmembrane tyrosine phosphatase associates with liprin-alpha proteins and colocalizes with liprin-alpha1 at focal adhesions. LAR has been implicated in axon guidance, and liprins are involved in synapse formation and synapse protein traffi
Autor:
Alma L. Burlingame, Michel Streuli, David S. Bredt, Jonathan C. Trinidad, Toshinari Kazuta, Roger A. Nicoll, Fred W. Kauer, Masaki Fukata, Olav Olsen, Kimberly A. Moore, Hidemi Misawa
Publikováno v:
The Journal of Cell Biology
Synapses are highly specialized intercellular junctions organized by adhesive and scaffolding molecules that align presynaptic vesicular release with postsynaptic neurotransmitter receptors. The MALS/Veli–CASK–Mint-1 complex of PDZ proteins occur
Autor:
Michel Streuli, Quintus G. Medley, Carles Serra-Pagès, Kouichi Tachibana, Hai Ngo, Elizabeth G. Buchbinder
Publikováno v:
Journal of Biological Chemistry. 278:13265-13270
The Trio guanine nucleotide exchange factor functions in neural development in Caenorhabditis elegans and Drosophila and in the development of neural tissues and skeletal muscle in mouse. The association of Trio with the Lar tyrosine phosphatase led
Autor:
Carles Serra-Pagès, Anthone W. Dunah, Michael Wyszynski, Michel Streuli, Maria Passafaro, Richard J. Weinberg, Eunjoon Kim, Juli G. Valtschanoff, Morgan Sheng
Publikováno v:
Neuron. 34:39-52
Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-α/SYD2 family of proteins that interact with LAR receptor protein ty
Publikováno v:
Journal of Biological Chemistry. 276:47530-47541
Signaling specificity of Rho GTPase pathways is achieved in part by selective interaction between members of the Dbl family guanine nucleotide exchange factors (GEFs) and their Rho GTPase substrates. For example, Trio, GEF-H1, and Tiam1 are a subset