Zobrazeno 1 - 10
of 375
pro vyhledávání: '"Michel Roberge"'
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103891- (2022)
Summary: Alport syndrome, a disease of kidney, ear, and eye, is caused by pathogenic variants in the COL4A3, COL4A4, or COL4A5 genes encoding collagen α3α4α5(IV) of basement membranes. Collagen IV chains that are truncated due to nonsense variants
Externí odkaz:
https://doaj.org/article/a879f32f26914813b12c4caa57e43e93
Autor:
Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge, Haakon B. Nygaard
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the progranulin gene (GRN
Externí odkaz:
https://doaj.org/article/a734b9c2da774facb813e45baefeeee9
Autor:
Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Carla Zimmerman, Kunho Choi, Stephane Flibotte, Michel Roberge
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3001221 (2021)
Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC readthrough and restore low levels of full-length functional proteins. However, concomitant inhi
Externí odkaz:
https://doaj.org/article/6c867feb7e4246c7815da789e71e9712
Autor:
Edward J. Morris, Eiko Kawamura, Jordan A. Gillespie, Aruna Balgi, Nagarajan Kannan, William J. Muller, Michel Roberge, Shoukat Dedhar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cancer cells have amplified centrosomes and deal with this abnormality by clustering them together so that they can be segregated in daughter cells. Here the authors perform a screening looking for inhibitors of this clustering process and find that
Externí odkaz:
https://doaj.org/article/58af0d7ff4e94bbd92f3feae3e7e8595
Autor:
Michael W Ferguson, Chloe A N Gerak, Christalle C T Chow, Ettore J Rastelli, Kyle E Elmore, Florian Stahl, Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Don M Coltart, Michel Roberge
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216423 (2019)
Nonsense mutations constitute ~10% of TP53 mutations in cancer. They introduce a premature termination codon that gives rise to truncated p53 protein with impaired function. The aminoglycoside G418 can induce TP53 premature termination codon readthro
Externí odkaz:
https://doaj.org/article/1d2d9585b10040e6ac89ed7b01a18a9b
Autor:
Maggie C. Duncan, Pascal Amoa Onguéné, Ibuki Kihara, Derrick N. Nebangwa, Maya E. Naidu, David E. Williams, Aruna D. Balgi, Kerstin Andrae-Marobela, Michel Roberge, Raymond J. Andersen, Masahiro Niikura, Fidele Ntie-Kang, Ian Tietjen
Publikováno v:
Molecules, Vol 25, Iss 12, p 2903 (2020)
The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. The M2 protein of influenza A is a proton-gated, proton-selective ion channel, which is essential for influenza replication and an es
Externí odkaz:
https://doaj.org/article/fc76e550588444198bd70b98aa4a91fc
Autor:
Mark D Mathew, Neal D Mathew, Angela Miller, Mike Simpson, Vinci Au, Stephanie Garland, Marie Gestin, Mark L Edgley, Stephane Flibotte, Aruna Balgi, Jennifer Chiang, Guri Giaever, Pamela Dean, Audrey Tung, Michel Roberge, Calvin Roskelley, Tom Forge, Corey Nislow, Donald Moerman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005058 (2016)
The lack of new anthelmintic agents is of growing concern because it affects human health and our food supply, as both livestock and plants are affected. Two principal factors contribute to this problem. First, nematode resistance to anthelmintic dru
Externí odkaz:
https://doaj.org/article/bf918819764c48fb8380f8fa310027ae
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114964 (2014)
Autophagy is a cellular catabolic process responsible for the degradation of cytoplasmic constituents, including organelles and long-lived proteins, that helps maintain cellular homeostasis and protect against various cellular stresses. Verteporfin i
Externí odkaz:
https://doaj.org/article/612c93ca682f46e494132106b89f49ac
Autor:
Wieslawa H Dragowska, Sherry A Weppler, Jun Chih Wang, Ling Yan Wong, Anita I Kapanen, Jenna S Rawji, Corinna Warburton, Mohammed A Qadir, Elizabeth Donohue, Michel Roberge, Sharon M Gorski, Karen A Gelmon, Marcel B Bally
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76503 (2013)
Gefitinib (Iressa(®), ZD1839) is a small molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. We report on an early cellular response to gefitinib that involves induction of functional autophagic flux in phenotypically
Externí odkaz:
https://doaj.org/article/8ebd620cddfb45099c4b8064dc11bf52
Autor:
Aruna D Balgi, Jun Wang, Daphne Y H Cheng, Chunlong Ma, Tom A Pfeifer, Yoko Shimizu, Hilary J Anderson, Lawrence H Pinto, Robert A Lamb, William F DeGrado, Michel Roberge
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55271 (2013)
The M2 proton channel of the influenza A virus is the target of the anti-influenza drugs amantadine and rimantadine. The effectiveness of these drugs has been dramatically limited by the rapid spread of drug resistant mutations, mainly at sites S31N,
Externí odkaz:
https://doaj.org/article/583383e4b889432f8f5d98d4d8e9e57d