The stereospecific interaction sites and target specificity of cGMP analogs in mouse cortex

Autor: Per Ekström, Frank Schwede, Michel Rasmussen, Charlotte Welinder

Publikováno v: Chemical Biology & Drug Design. 99:206-221

cGMP interactors play a role in several pathologies and may be targets for cGMP analog-based drugs, but the success of targeting depends on the biochemical stereospecificity between the cGMP-analog and the interactor. The stereospecificity between ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea36229969c178e9d14b705be7fa9bb
https://doi.org/10.1111/cbdd.13976

Enhanced cGMP Interactor Rap Guanine Exchange Factor 4 (EPAC2) Expression and Activity in Degenerating Photoreceptors: A Neuroprotective Response?

Autor: Ekström, Michel Rasmussen, Jiaming Zhou, Frank Schwede, Per

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4619

The disease retinitis pigmentosa (RP) leads to photoreceptor degeneration by a yet undefined mechanism(s). In several RP mouse models (i.e., rd mice), a high cyclic GMP (cGMP) level within photoreceptors is detected, suggesting that cGMP plays a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::1a9ff80f2d8a73c3fda1810ac2f8df92

α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α

Autor: Helena Borland, Izabela Rasmussen, Kaare Bjerregaard-Andersen, Michel Rasmussen, Anders Olsen, Frederik Vilhardt

Publikováno v: Borland, H, Rasmussen, I, Bjerregaard-Andersen, K, Rasmussen, M, Olsen, A & Vilhardt, F 2022, ' α-synuclein build-up is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α ', Journal of Biological Chemistry, vol. 298, no. 11, 102531 . https://doi.org/10.1016/j.jbc.2022.102531
Borland, H, Rasmussen, I, Bjerregaard-Andersen, K, Rasmussen, M, Olsen, A & Vilhardt, F 2022, ' α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α ', The Journal of Biological Chemistry, vol. 298, no. 11, 102531 . https://doi.org/10.1016/j.jbc.2022.102531

α-synucleinopathy is driven by an imbalance of synthesis and degradation of α-synuclein (αSyn), causing a build up of αSyn aggregates and post-translationally modified species, which not only interfere with normal cellular metabolism but also by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91377a8e5e36a8f4dae8987519206b4f
https://pubmed.ncbi.nlm.nih.gov/36162505