Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.

Autor: Novel N Chegou, Paulin N Essone, Andre G Loxton, Kim Stanley, Gillian F Black, Gian D van der Spuy, Paul D van Helden, Kees L Franken, Shreemanta K Parida, Michel R Klein, Stefan H E Kaufmann, Tom H M Ottenhoff, Gerhard Walzl

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38501 (2012)

BACKGROUND: Recent interferon gamma (IFN-γ)-based studies have identified novel Mycobacterium tuberculosis (M.tb) infection phase-dependent antigens as diagnostic candidates. In this study, the levels of 11 host markers other than IFN-γ, were evalu

Externí odkaz: https://doaj.org/article/37149e2a1cd749c5846b30da5a5ae205

Four-gene pan-African blood signature predicts progression to tuberculosis

Autor: Sara Suliman, Ethan G. Thompson, Jayne Sutherland, January Weiner, Martin O. C. Ota, Smitha Shankar, Adam Penn-Nicholson, Bonnie Thiel, Mzwandile Erasmus, Jeroen Maertzdorf, Fergal J. Duffy, Philip C. Hill, E. Jane Hughes, Kim Stanley, Katrina Downing, Michelle L. Fisher, Joe Valvo, Shreemanta K. Parida, Gian van der Spuy, Gerard Tromp, Ifedayo M. O. Adetifa, Simon Donkor, Rawleigh Howe, Harriet Mayanja-Kizza, W. Henry Boom, Hazel M. Dockrell, Tom H. M. Ottenhoff, Mark Hatherill, Alan Aderem, Willem A. Hanekom, Thomas J. Scriba, Stefan H. E. Kaufmann, Daniel E. Zak, Gerhard Walzl, Gillian F. Black, Magdalena Kriel, Nelita Du Plessis, Nonhlanhla Nene, Teri Roberts, Leanie Kleynhans, Andrea Gutschmidt, Bronwyn Smith, Andre G. Loxton, Novel N. Chegou, Gerhardus Tromp, David Tabb, Michel R. Klein, Marielle C. Haks, Kees L. M. C. Franken, Annemieke Geluk, Krista E. van Meijgaarden, Simone A. Joosten, Moses Joloba, Sarah Zalwango, Mary Nsereko, Brenda Okwera, Hussein Kisingo, Robert Golinski, Marc Jacobson, Hazel Dockrell, Steven Smith, Patricia Gorak-Stolinska, Yun-Gyoung Hur, Maeve Lalor, Ji-Sook Lee, Amelia C. Crampin, Neil French, Bagrey Ngwira, Anne Ben-Smith, Kate Watkins, Lyn Ambrose, Felanji Simukonda, Hazzie Mvula, Femia Chilongo, Jacky Saul, Keith Branson, Hassan Mahomed, Nicole Bilek, Onke Xasa, Ashley Veldsman, Michelle Fisher, Humphrey Mulenga, Brian Abel, Mark Bowmaker, Benjamin Kagina, William Kwong Chung, Jerry Sadoff, Donata Sizemore, S. Ramachandran, Lew Barker, Michael Brennan, Frank Weichold, Stefanie Muller, Larry Geiter, Desta Kassa, Almaz Abebe, Tsehayenesh Mesele, Belete Tegbaru, Debbie van Baarle, Frank Miedema, Adane Mihret, Abraham Aseffa, Yonas Bekele, Rachel Iwnetu, Mesfin Tafesse, Lawrence Yamuah, Martin Ota, Philip Hill, Richard Adegbola, Tumani Corrah, Martin Antonio, Toyin Togun, Ifedayo Adetifa, Peter Andersen, Ida Rosenkrands, Mark Doherty, Karin Weldingh, Gary Schoolnik, Gregory Dolganov, Tran Van, Fazlin Kafaar, Leslie Workman, Yolundi Cloete, Deborah Abrahams, Sizulu Moyo, Sebastian Gelderbloem, Michele Tameris, Hennie Geldenhuys, Willem Hanekom, Gregory Hussey, Rodney Ehrlich, Suzanne Verver

Publikováno v: American journal of respiratory and critical care medicine, 197(9), 1198-1208. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 197(9), 1198. American Thoracic Society
American journal of respiratory and critical care medicine, vol 197, iss 9
American Journal of Respiratory and Critical Care Medicine, 197(9), 1198-1208

Rationale: Contacts of patients with tuberculosis (TB) constitute an important target population for preventive measures because they are at high risk of infection with Mycobacterium tuberculosis and progression to disease. Objectives: We investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918b39963924be0a306581252709d36a
https://pure.amc.nl/en/publications/fourgene-panafrican-blood-signature-predicts-progression-to-tuberculosis(040a7060-f30a-4cfa-a0f3-e5fd8d66f323).html

MAIC: A data and knowledge-based system for supporting the maintenance of chemical plant

Autor: Mario Milanese, Michel R. Klein, Giovani Pieri

Publikováno v: International Journal of Production Economics. 79:143-159

The goal of the present paper is to present MAIC, a knowledge-based decision support system for the maintenance of chemical plant. After recalling the nature of the problem, the system is described. The main functions of the system being: • The man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab44e87f7b1e78b1efce0308c709dc16
https://doi.org/10.1016/s0925-5273(01)00208-0

Using OPTRANS object as a KB–DSS development environment for designing DSS for production management

Autor: Michel R. Klein, Robert W. Grubbström

Publikováno v: European Journal of Operational Research. 109:264-285

In this paper we briefly recall the objectives of knowledge based decision support system development environments. Some key design characteristics of OPTRANS object, a KB–DSS development environment are introduced. We present a production planning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be60e8b97fac2c8792c41c9fa40d8d06
https://doi.org/10.1016/s0377-2217(98)00056-3

Knowledge Based DSS

Autor: Michel R. Klein

“A knowledge based DSS is a computer information system that provides information and methodological knowledge (domain knowledge and decision methodology knowledge) by means of analytical decision models and access to data base and knowledge base t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2360a2ce58fb32c4cbb5b85af116972
https://doi.org/10.4018/978-1-59904-843-7.ch063