Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Michel R, Leroux"'
Autor:
Paul W. Chrystal, Nils J. Lambacher, Lance P. Doucette, James Bellingham, Elena R. Schiff, Nicole C. L. Noel, Chunmei Li, Sofia Tsiropoulou, Geoffrey A. Casey, Yi Zhai, Nathan J. Nadolski, Mohammed H. Majumder, Julia Tagoe, Fabiana D’Esposito, Maria Francesca Cordeiro, Susan Downes, Jill Clayton-Smith, Jamie Ellingford, Genomics England Research Consortium, Omar A. Mahroo, Jennifer C. Hocking, Michael E. Cheetham, Andrew R. Webster, Gert Jansen, Oliver E. Blacque, W. Ted Allison, Ping Yee Billie Au, Ian M. MacDonald, Gavin Arno, Michel R. Leroux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Motile and non-motile cilia have distinct functions and protein complexes associated with them. Here, the authors show the conserved protein CFAP20 is important for both motile and non-motile cilia and is distinct from other ciliopathy-associated dom
Externí odkaz:
https://doaj.org/article/a85ce5f9aafc4ed1a65a7a9f8a648d61
Autor:
Peter Canning, Kwangjin Park, João Gonçalves, Chunmei Li, Conor J. Howard, Timothy D. Sharpe, Liam J. Holt, Laurence Pelletier, Alex N. Bullock, Michel R. Leroux
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 885-894 (2018)
Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins sugges
Externí odkaz:
https://doaj.org/article/faa754dea4684d8fa82062ed9e4ac060
Autor:
Catrina M Loucks, Kwangjin Park, Denise S Walker, Andrea H McEwan, Tiffany A Timbers, Evan L Ardiel, Laura J Grundy, Chunmei Li, Jacque-Lynne Johnson, Julie Kennedy, Oliver E Blacque, William Schafer, Catharine H Rankin, Michel R Leroux
Publikováno v:
eLife, Vol 8 (2019)
Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular signaling. Yet, the roles of cilia in these neurons are poorly understood. To shed light into their functions, we stu
Externí odkaz:
https://doaj.org/article/187f16f490b2476e89b17a0470140d3f
Autor:
Teunis J P van Dam, Julie Kennedy, Robin van der Lee, Erik de Vrieze, Kirsten A Wunderlich, Suzanne Rix, Gerard W Dougherty, Nils J Lambacher, Chunmei Li, Victor L Jensen, Michel R Leroux, Rim Hjeij, Nicola Horn, Yves Texier, Yasmin Wissinger, Jeroen van Reeuwijk, Gabrielle Wheway, Barbara Knapp, Jan F Scheel, Brunella Franco, Dorus A Mans, Erwin van Wijk, François Képès, Gisela G Slaats, Grischa Toedt, Hannie Kremer, Heymut Omran, Katarzyna Szymanska, Konstantinos Koutroumpas, Marius Ueffing, Thanh-Minh T Nguyen, Stef J F Letteboer, Machteld M Oud, Sylvia E C van Beersum, Miriam Schmidts, Philip L Beales, Qianhao Lu, Rachel H Giles, Radek Szklarczyk, Robert B Russell, Toby J Gibson, Colin A Johnson, Oliver E Blacque, Uwe Wolfrum, Karsten Boldt, Ronald Roepman, Victor Hernandez-Hernandez, Martijn A Huynen
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216705 (2019)
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliar
Externí odkaz:
https://doaj.org/article/206fb09f592a41a7979de76d71996765
Autor:
Kwangjin Park, Michel R Leroux
Publikováno v:
EMBO reports. 23(12)
The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its environment. Acquiring these functions required the compartmentalization of a dynein-based motility apparatus and signaling proteins within a discrete subcel
Autor:
Victor L Jensen, Stephen Carter, Anna A W M Sanders, Chunmei Li, Julie Kennedy, Tiffany A Timbers, Jerry Cai, Noemie Scheidel, Breandán N Kennedy, Ryan D Morin, Michel R Leroux, Oliver E Blacque
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006469 (2016)
Primary cilia are specialised sensory and developmental signalling devices extending from the surface of most eukaryotic cells. Defects in these organelles cause inherited human disorders (ciliopathies) such as retinitis pigmentosa and Bardet-Biedl s
Externí odkaz:
https://doaj.org/article/6dd5e2f10a5341d08051a0d2fe967767
Autor:
Tiffany A Timbers, Stephanie J Garland, Swetha Mohan, Stephane Flibotte, Mark Edgley, Quintin Muncaster, Vinci Au, Erica Li-Leger, Federico I Rosell, Jerry Cai, Suzanne Rademakers, Gert Jansen, Donald G Moerman, Michel R Leroux
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006235 (2016)
Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major bottleneck, however, namely the cloning of corresponding genes causing the phenotypic variation. R
Externí odkaz:
https://doaj.org/article/92ee75ab091a429ab63000dd1b802093
Autor:
Chunmei Li, Victor L Jensen, Kwangjin Park, Julie Kennedy, Francesc R Garcia-Gonzalo, Marta Romani, Roberta De Mori, Ange-Line Bruel, Dominique Gaillard, Bérénice Doray, Estelle Lopez, Jean-Baptiste Rivière, Laurence Faivre, Christel Thauvin-Robinet, Jeremy F Reiter, Oliver E Blacque, Enza Maria Valente, Michel R Leroux
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002416 (2016)
Cilia have a unique diffusion barrier ("gate") within their proximal region, termed transition zone (TZ), that compartmentalises signalling proteins within the organelle. The TZ is known to harbour two functional modules/complexes (Meckel syndrome [M
Externí odkaz:
https://doaj.org/article/8218a5f05b2d4ec7ac530fd44daeffc4
Autor:
Laura E Yee, Francesc R Garcia-Gonzalo, Rachel V Bowie, Chunmei Li, Julie K Kennedy, Kaveh Ashrafi, Oliver E Blacque, Michel R Leroux, Jeremy F Reiter
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005627 (2015)
Mutations in genes encoding cilia proteins cause human ciliopathies, diverse disorders affecting many tissues. Individual genes can be linked to ciliopathies with dramatically different phenotypes, suggesting that genetic modifiers may participate in
Externí odkaz:
https://doaj.org/article/f350bad5591849009c0460aaad0857a5
Autor:
Yong Tae Kwon, Ah Jung Heo, Jill A. Rosenfeld, Eliane Beauregard-Lacroix, Carlos A. Bacino, Philippe M. Campeau, Maren Wenzel, Valentina Stanley, Hamad Al Deiab, Michel R. Leroux, Christine Kondratev, Justine Rousseau, Katherine Neas, Brett H. Graham, Matias Wagner, Chunmei Li, Fuad Al Mutairi, Joseph G. Gleeson, Maha S. Zaki
Publikováno v:
Am. J. Hum. Genet. 108, 134-147 (2021)
Am J Hum Genet
Am J Hum Genet
Summary The ubiquitin-proteasome system facilitates the degradation of unstable or damaged proteins. UBR1–7, which are members of hundreds of E3 ubiquitin ligases, recognize and regulate the half-life of specific proteins on the basis of their N-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435234a9be27dd031106b25bcf587d02
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60979
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60979