Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Michel Prévost"'
Autor:
Carla Eymard, Amarender Manchoju, Abir Almazloum, Starr Dostie, Michel Prévost, Mona Nemer, Yvan Guindon
Publikováno v:
Molecules, Vol 29, Iss 7, p 1647 (2024)
The design of novel 4′-thionucleoside analogues bearing a C2′ stereogenic all-carbon quaternary center is described. The synthesis involves a highly diastereoselective Mukaiyama aldol reaction, and a diastereoselective radical-based vinyl group t
Externí odkaz:
https://doaj.org/article/0ab352fb8fa74e769dc4c35343b31321
Autor:
Amarender Manchoju, Renaud Zelli, Gang Wang, Carla Eymard, Adrian Oo, Mona Nemer, Michel Prévost, Baek Kim, Yvan Guindon
Publikováno v:
Molecules, Vol 27, Iss 2, p 564 (2022)
The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reac
Externí odkaz:
https://doaj.org/article/ad34ce07860c46719f21511381a19069
Publikováno v:
Canadian Journal of Chemistry. 98:466-470
An acyclic approach to synthesize thiofuranoside N-glycosides bearing an adenine nucleobase is presented herein. This approach provides a significant improvement in terms of regio- and diastereoselectivity compared with the current paradigms used for
Autor:
Scott C. Foster, Amarender Manchoju, Starr Dostie, Yvan Guindon, Michel Prévost, Tommy Lussier, Philippe Mochirian, Gang Wang
Publikováno v:
The Journal of Organic Chemistry. 84:16055-16067
The synthesis of novel nucleoside analogues bearing a C3′ all-carbon quaternary center and a C2′-hydroxy substituent is described. The all-carbon stereogenic center was generated through an intramolecular 7-endo attack of a silyl-tethered allyl m
Synthesis of Sialyl LewisX Glycomimetics Bearing a Bicyclic 3-O,4-C-Fused Galactopyranoside Scaffold
Autor:
Wael Maharsy, Mathieu Joyal, Ryan D. Simard, Pina Colarusso, Kamala D. Patel, Mona Nemer, Gianna Di Censo, Yvan Guindon, Michel Prévost, Janie Beauregard, Laura Gillard
Publikováno v:
The Journal of Organic Chemistry. 84:7372-7387
Reported herein is the synthesis of sialyl LewisX analogues bearing a trans-bicyclo[4.4.0] dioxadecane-modified 3- O,4- C-fused galactopyranoside scaffold that locks the carboxylate pharmacophore in either the axial or equatorial position. This novel
Autor:
Michel Prévost, Yvan Guindon, Carla Eymard, Louis Leblanc, Starr Dostie, Tommy Lussier, Fabiola Becerril-Jiménez
Publikováno v:
The Journal of organic chemistry. 84(22)
The design of novel nucleoside analogues bearing a C2' all-carbon quaternary center is described. The construction of this all-carbon stereogenic center involves the use of photoredox catalysis to initiate an intramolecular attack of a silyl-tethered
Autor:
Philippe Mochirian, Nicholas Andrella, Michel Prévost, Yvan Guindon, Kashif Tanveer, Starr Dostie, Ariana Rostami, Guillaume Tambutet
Publikováno v:
The Journal of Organic Chemistry. 81:10769-10790
Nucleoside analogues bearing a fluorine in the C2′-position have been synthesized by SN2-like cyclizations of acyclic thioaminal precursors. This strategy provides access to two scaffolds, d-1′,2′-cis-thiofuranosides and d-1′,2′-trans-furan
Autor:
Ryan D, Simard, Mathieu, Joyal, Laura, Gillard, Gianna, Di Censo, Wael, Maharsy, Janie, Beauregard, Pina, Colarusso, Kamala D, Patel, Michel, Prévost, Mona, Nemer, Yvan, Guindon
Publikováno v:
The Journal of organic chemistry. 84(11)
Reported herein is the synthesis of sialyl Lewis
Autor:
Wael Maharsy, Mona Nemer, Yvan Guindon, Carole-Anne Lefebvre, Starr Dostie, Laura Collins, Janie Beauregard, Marc-Olivier Labbé, Michel Prévost
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126983
A synthetic strategy to access a novel family of nucleoside analogues bearing a C3'-nitrile substituted all-carbon quaternary center is presented herein. These purine bearing scaffolds were tested in two pancreatic cancer cell lines harboring either