Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Michel O, Steinmetz"'
Autor:
Maximilian Wranik, Michal W. Kepa, Emma V. Beale, Daniel James, Quentin Bertrand, Tobias Weinert, Antonia Furrer, Hannah Glover, Dardan Gashi, Melissa Carrillo, Yasushi Kondo, Robin T. Stipp, Georgii Khusainov, Karol Nass, Dmitry Ozerov, Claudio Cirelli, Philip J. M. Johnson, Florian Dworkowski, John H. Beale, Scott Stubbs, Thierry Zamofing, Marco Schneider, Kristina Krauskopf, Li Gao, Oliver Thorn-Seshold, Christoph Bostedt, Camila Bacellar, Michel O. Steinmetz, Christopher Milne, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such experi
Externí odkaz:
https://doaj.org/article/f224092cc9184c46b2af0e3942817cf2
Autor:
Jean Herman, Els Vanstreels, Dorothée Bardiot, Andrea E Prota, Natacha Gaillard, Ling-Jie Gao, Thomas Vercruysse, Leentje Persoons, Tinne Daems, Mark Waer, Piet Herdewijn, Thierry Louat, Michel O Steinmetz, Steven De Jonghe, Ben Sprangers, Dirk Daelemans
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0307153 (2024)
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel group of microtubule-ta
Externí odkaz:
https://doaj.org/article/6fdecf164cea42cdbd9b349cb2345daf
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitud
Externí odkaz:
https://doaj.org/article/31ccc9f5c1c7420b8b23b5fa45bdc9ee
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Publikováno v:
eLife, Vol 12 (2023)
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes
Externí odkaz:
https://doaj.org/article/ae0411d1a2f8477a839b678a56356407
Autor:
Natacha Gaillard, Ashwani Sharma, Izra Abbaali, Tianyang Liu, Fiona Shilliday, Alexander D Cook, Valentin Ehrhard, Mamata Bangera, Anthony J Roberts, Carolyn A Moores, Naomi Morrissette, Michel O Steinmetz
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-12 (2021)
Abstract Infectious diseases caused by apicomplexan parasites remain a global public health threat. The presence of multiple ligand‐binding sites in tubulin makes this protein an attractive target for anti‐parasite drug discovery. However, despit
Externí odkaz:
https://doaj.org/article/c0f9fdde1699413aa5e8e00497b1e055
Autor:
Charlotte Guyomar, Clément Bousquet, Siou Ku, John M Heumann, Gabriel Guilloux, Natacha Gaillard, Claire Heichette, Laurence Duchesne, Michel O Steinmetz, Romain Gibeaux, Denis Chrétien
Publikováno v:
eLife, Vol 11 (2022)
Microtubules are tubes of about 25 nm in diameter that are critically involved in a variety of cellular functions, including motility, compartmentalization, and division. They are considered as pseudo-helical polymers whose constituent αβ-tubulin h
Externí odkaz:
https://doaj.org/article/9c51fb0f95b84d70af1fa4796c5053a7
Autor:
Karol Nass, Robert Cheng, Laura Vera, Aldo Mozzanica, Sophie Redford, Dmitry Ozerov, Shibom Basu, Daniel James, Gregor Knopp, Claudio Cirelli, Isabelle Martiel, Cecilia Casadei, Tobias Weinert, Przemyslaw Nogly, Petr Skopintsev, Ivan Usov, Filip Leonarski, Tian Geng, Mathieu Rappas, Andrew S. Doré, Robert Cooke, Shahrooz Nasrollahi Shirazi, Florian Dworkowski, May Sharpe, Natacha Olieric, Camila Bacellar, Rok Bohinc, Michel O. Steinmetz, Gebhard Schertler, Rafael Abela, Luc Patthey, Bernd Schmitt, Michael Hennig, Jörg Standfuss, Meitian Wang, Christopher J. Milne
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 965-975 (2020)
Long-wavelength pulses from the Swiss X-ray free-electron laser (XFEL) have been used for de novo protein structure determination by native single-wavelength anomalous diffraction (native-SAD) phasing of serial femtosecond crystallography (SFX) data.
Externí odkaz:
https://doaj.org/article/ad7aad98478142d29b1d85fde6face15
Autor:
Joseph Atherton, Yanzhang Luo, Shengqi Xiang, Chao Yang, Ankit Rai, Kai Jiang, Marcel Stangier, Annapurna Vemu, Alexander D. Cook, Su Wang, Antonina Roll-Mecak, Michel O. Steinmetz, Anna Akhmanova, Marc Baldus, Carolyn A. Moores
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
CKK domain containing CAMSAP/Patronins recognise and regulate microtubule (MT) minus end dynamics. Here the authors compare cryo-EM structures of MT-bound human CKK and Naegleria gruberi CKK which lacks minus-end binding preference, finding NgCKK has
Externí odkaz:
https://doaj.org/article/3d87bd15c883481392c7b1e0dbdc5c01
Autor:
Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 755-764 (2019)
Externí odkaz:
https://doaj.org/article/25fe86c26b2f41b2afb5b7ee20b13b6c
Autor:
Joseph Atherton, Jessica JA Hummel, Natacha Olieric, Julia Locke, Alejandro Peña, Steven S Rosenfeld, Michel O Steinmetz, Casper C Hoogenraad, Carolyn A Moores
Publikováno v:
eLife, Vol 9 (2020)
Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution. Kinesin-binding protei
Externí odkaz:
https://doaj.org/article/afd807016c264f458e22f75004d72461