Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Michel Maitre"'
Autor:
Michel Maitre, Hélène Jeltsch-David, Nwife Getrude Okechukwu, Christian Klein, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder with neuronal and synaptic losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, and tangles containing tau (tubulin-associated unit) protein. While f
Externí odkaz:
https://doaj.org/article/bc58c801de57427cb9f3a18a2b473543
Autor:
Christian Klein, Guy Roussel, Susana Brun, Cristina Rusu, Christine Patte-Mensah, Michel Maitre, Ayikoe-Guy Mensah-Nyagan
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear. Because growing evidence suggested that the stimulation of prot
Externí odkaz:
https://doaj.org/article/6b1440d4880b423c9621aa30a13480e7
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6974 (2021)
Xanthurenic acid (XA) is a metabolite of the kynurenine pathway (KP) synthetized in the brain from dietary or microbial tryptophan that crosses the blood-brain barrier through carrier-mediated transport. XA and kynurenic acid (KYNA) are two structura
Externí odkaz:
https://doaj.org/article/450c6b4ac77b401eb5217c3fd13646a0
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 12, Iss C, Pp 99-102 (2017)
We report an isolated sulfite oxidase deficiency in the first child boy of a non-consanguineous Caucasian family. He's a compound heterozygote for the sulfite oxidase gene, presenting low cystine, undetectable homocysteine and normal uric acid blood
Externí odkaz:
https://doaj.org/article/c241690e042a4c8389f01cab0029d58d
Autor:
Omar Taleb, Mohammed Maammar, Daniel Brumaru, Jean-Jacques Bourguignon, Martine Schmitt, Christian Klein, Véronique Kemmel, Michel Maitre, Ayikoe Guy Mensah-Nyagan
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48553 (2012)
Xanthurenic acid (XA) is a metabolite of the tryptophan oxidation pathway through kynurenine and 3-hydroxykynurenine. XA was until now considered as a detoxification compound and dead-end product reducing accumulation of reactive radical species. Apa
Externí odkaz:
https://doaj.org/article/66a5faffafe7420a847cbed2c658ef19
Publikováno v:
Progress in Neurobiology
Progress in Neurobiology, In press, ⟨10.1016/j.pneurobio.2020.101800⟩
Progress in Neurobiology, In press, ⟨10.1016/j.pneurobio.2020.101800⟩
International audience; Among several processes, a decrease in amyloid-beta (Aβ) peptide elimination is thought to be one of the major pathophysiological factors in Alzheimer’s disease (AD). Neprilysin (NEP) is a key metalloproteinase controlling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b79535401738ab239e31151fa5262a
https://hal.science/hal-02620451
https://hal.science/hal-02620451
Publikováno v:
NPG Neurologie - Psychiatrie - Gériatrie. 17:352-364
Resume La maladie d’Alzheimer comprend une forme precoce (entre 30–55 ans) et une forme tardive (ou sporadique) qui apparait le plus souvent entre 80–90 ans et qui est de loin la plus frequente. Cette derniere (prevalence de 10 a 30 % apres 65
Publikováno v:
Neuroscience. 329:226-238
Kynurenine pathway metabolites (KPM) are thought to be synthesized mainly by non-neuronal cells in the mammalian brain. KPM are of particular interest because several studies demonstrated their implication in various disorders of the nervous system.
Publikováno v:
Medicinal Research Reviews. 36:363-388
γ-Hydroxybutyrate (GHB) is both a natural brain compound with neuromodulatory properties at central GABAergic synapses (micromolar concentration range) and also a drug (Xyrem(R) ) clinically used for the treatment of various neurological symptoms (m
Autor:
Géraldine Leva, Christian Klein, Christine Patte-Mensah, Ayikoe Guy Mensah-Nyagan, Michel Maitre, Jean-Christophe Cassel, Chantal Mathis
Publikováno v:
Neurobiology of Aging. 36:832-844
The chronic decrease of brain amyloid-β (Aβ) peptides is an emerging therapeutic for Alzheimer's disease, but no such treatment has achieved clinical validation yet. In vivo, some brain proteases, including neprilysin, possess the ability of degrad