Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Michel Legraverend"'
Publikováno v:
Dyes and Pigments. 105:145-151
New 6-amino-8-styryl purines were synthesized using direct C–H bond functionalization. These push–pull compounds showed strong fluorescence, high quantum yields and a noteworthy fluorosolvatochromism. Deprotected purines 7a – c are promising ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd0c48f70c68be545c13de89f99a5284
https://doi.org/10.1016/j.dyepig.2014.01.025
https://doi.org/10.1016/j.dyepig.2014.01.025
Publikováno v:
Synthesis. 46:933-942
A palladium(II)-catalyzed, copper(I)-mediated Liebeskind–Srogl cross-coupling for the C-6 arylation/alkenylation on purine scaffold is reported. Various boronic acids reacted readily with 8-substituted 6-thiophenylpurines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80fbc2e3dfc719a6fe3388a086f814b3
https://doi.org/10.1055/s-0033-1340734
https://doi.org/10.1055/s-0033-1340734
Publikováno v:
European Journal of Organic Chemistry. 2012:2889-2893
The synthesis of 8-amido- and 8-aminopurines by a single palladium-catalyzed protocol is reported. The method proceeds efficiently and tolerates a wide range of amides and amines as coupling partners, including aryl, alkyl, sulfone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb62548de12a56200ed7e08054aa1e6
https://doi.org/10.1002/ejoc.201200168
https://doi.org/10.1002/ejoc.201200168
Autor:
Sandrine Piguel, Michel Legraverend
Publikováno v:
Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2007, 72 (18), pp.7026-9. ⟨10.1021/jo071196p⟩
Journal of Organic Chemistry, American Chemical Society, 2007, 72 (18), pp.7026-9. ⟨10.1021/jo071196p⟩
We report herein the palladium(0)/Xantphos-catalyzed cross-coupling of various amides with 2,6-dihalogenopurines, with substituent-dependent regioselectivity. Furthermore, subjecting the same 2,6-dihalogenopurines to SNAr conditions with amide/NaH in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff0a8d81b849d43749b86e3c8a7d873
https://doi.org/10.1021/jo071196p
https://doi.org/10.1021/jo071196p
Publikováno v:
Tetrahedron. 58:7911-7923
The preparation of 6-chloro-2-iodo-9-tetrahydropyranylpurine ( 2 ), was achieved in three high yield steps from 6-chloropurine. This derivative was then selectively substituted at C-6 by reaction with a benzylthiol to give 3 , a versatile intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d81ecb0f4ce3a87adc41a6d12c9b79c
https://doi.org/10.1016/s0040-4020(02)00905-5
https://doi.org/10.1016/s0040-4020(02)00905-5
Autor:
Céline Facca, Michel Legraverend, Gérard Faye, Thérèse Mayi, Sandrine Anne, Laurence Vernis, Meng-Er Huang
Publikováno v:
Journal of biotechnology. 195
Cyclin-dependent kinases (Cdk) play crucial roles in cell cycle progression. Aberrant activation of Cdk1 has been observed in a number of primary tumors and Cdk2 is deregulated in various malignancies. The therapeutic value of targeting Cdk1 and Cdk2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f95d7e483eb2f13160f0408306fd71
https://pubmed.ncbi.nlm.nih.gov/25541464
https://pubmed.ncbi.nlm.nih.gov/25541464
Publikováno v:
Tetrahedron Letters. 42:8161-8164
To validate a proposed solid support synthesis strategy for the construction of 2,6,9-trisubstituted purine based CDK inhibitors, the N-9 THP protected 6-benzylthio-2-iodopurine 11 was reacted with piperidine-2-methanol to give 12 . Alternatively, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51fe8f6244039ee64d23a368826a0b0
https://doi.org/10.1016/s0040-4039(01)01751-8
https://doi.org/10.1016/s0040-4039(01)01751-8
Autor:
Laura Tarrago-Litvak, Michel Legraverend, Marie-Line Andreola, Michel Ventura, Chi Hung Nguyen
Publikováno v:
Expert Opinion on Emerging Drugs. 6:225-238
In this overview, the antiviral properties of the Curie-pyridinone compounds, a new class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) developed as anti-HIV agents, are described. These compounds are hybrids between hydroxyethoxymethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71476d40a7b0a3275ef1f07895eb9f00
https://doi.org/10.1517/14728214.6.2.225
https://doi.org/10.1517/14728214.6.2.225
Publikováno v:
Journal of Heterocyclic Chemistry. 38:299-303
The synthesis of new purine derivatives designed to inhibit cell cycle regulating cyclin-dependent kinases (CDKs), is reported. These compounds, related to olomoucine and roscovitine, are characterised by the presence of apyrrolidine methanol substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::029645ba47ab636aadcd6cdcdc4fcd25
https://doi.org/10.1002/jhet.5570380145
https://doi.org/10.1002/jhet.5570380145
Publikováno v:
Journal of Medicinal Chemistry. 43:4098-4108
Several series of cyclin-dependent kinase inhibitors previously prepared in our laboratory were compared using 3D-QSAR (CDK1) and docking (CDK2) techniques. Evaluation of our own library of 93 purine derivatives served to establish the model which wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9615bf32510fd27ea85e8f48ff9a586d
https://doi.org/10.1021/jm000965t
https://doi.org/10.1021/jm000965t